Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring

Soyoung Park; Alice Jang; Sebastien G. Bouret

doi:10.1371/journal.pbio.3000296

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Open Access

Peer-reviewed

Research Article

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring

Soyoung Park,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, Los Angeles, California, United States of America
⨯
Alice Jang,

Roles Methodology

Affiliation The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, Los Angeles, California, United States of America

http://orcid.org/0000-0002-6916-4201

⨯
Sebastien G. Bouret

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: sebastien.bouret@inserm.fr

Affiliations Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France, University of Lille, FHU 1,000 Days for Health, Lille, France

http://orcid.org/0000-0002-4174-9769

⨯

Maternal obesity-induced endoplasmic reticulum stress causes metabolic alterations and abnormal hypothalamic development in the offspring

Soyoung Park,
Alice Jang,
Sebastien G. Bouret

Published: March 12, 2020
https://doi.org/10.1371/journal.pbio.3000296

About the Authors

Soyoung Park

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, Los Angeles, California, United States of America

Alice Jang

Roles Methodology

Affiliation The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, Los Angeles, California, United States of America

http://orcid.org/0000-0002-6916-4201

Sebastien G. Bouret

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: sebastien.bouret@inserm.fr

Affiliations Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France, University of Lille, FHU 1,000 Days for Health, Lille, France

http://orcid.org/0000-0002-4174-9769

Competing Interests

The authors have declared that no competing interests exist.

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Obesity
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Fatty acids
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Leptin
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Neonates
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Endoplasmic reticulum
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Diet
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Neurons
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Mouse models
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