ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

Liangzhong Lim; Yuanyuan Wei; Yimei Lu; Jianxing Song

doi:10.1371/journal.pbio.1002338

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Open Access

Peer-reviewed

Research Article

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

Liangzhong Lim,

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
⨯
Yuanyuan Wei,

Affiliation NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
⨯
Yimei Lu,

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
⨯
Jianxing Song

* E-mail: dbssjx@nus.edu.sg

Affiliations Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
⨯

ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43

Liangzhong Lim,
Yuanyuan Wei,
Yimei Lu,
Jianxing Song

Published: January 6, 2016
https://doi.org/10.1371/journal.pbio.1002338

About the Authors

Liangzhong Lim

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

Yuanyuan Wei

Affiliation NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

Yimei Lu

Affiliation Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

Jianxing Song

* E-mail: dbssjx@nus.edu.sg

Affiliations Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JS LL. Performed the experiments: LL YW YL. Analyzed the data: LL JS. Wrote the paper: JS.

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Prions
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Aqueous solutions
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Amyloid proteins
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Fluorescence
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NMR spectroscopy
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Amyotrophic lateral sclerosis
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Hydrogen bonding
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Point mutation
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