About the Authors
- Frank Schwede
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Affiliation BIOLOG Life Science Institute, Bremen, Germany
- Daniela Bertinetti
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Affiliation Department of Biochemistry, University of Kassel, Kassel, Germany
- Carianne N. Langerijs
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Affiliation Galapagos BV, CR Leiden, The Netherlands
- Michael A. Hadders
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Affiliation Department of Chemistry, Laboratory of Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
- Hans Wienk
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Affiliation Department of Chemistry, NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands
- Johanne H. Ellenbroek
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Affiliation Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
- Eelco J. P. de Koning
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Affiliations Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands, Hubrecht Institute/KNAW and University Medical Center Utrecht, Utrecht, The Netherlands
- Johannes L. Bos
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Affiliation Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, UMC Utrecht, Utrecht, The Netherlands
- Friedrich W. Herberg
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Affiliation Department of Biochemistry, University of Kassel, Kassel, Germany
- Hans-Gottfried Genieser
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Affiliation BIOLOG Life Science Institute, Bremen, Germany
- Richard A. J. Janssen
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Affiliation Galapagos BV, CR Leiden, The Netherlands
- Holger Rehmann
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* E-mail: h.rehmann@UMCutrecht.nl
Affiliation Molecular Cancer Research and Cancer Genomics Netherlands, Center for Molecular Medicine, UMC Utrecht, Utrecht, The Netherlands
Competing Interests
F.S. is an employee and H.-G.G. is the CEO of BIOLOG LSI, and C.N.L and R.A.J.J. are employees of Galapagos, BV.
Author Contributions
Conceived and designed the experiments: FS HR. Performed the experiments: FS DB CNL JHE MAH HR HW. Analyzed the data: FS DB CLHR FWH H-GG RAJ HW HR. Contributed reagents/materials/analysis tools: JHE EJPK. Wrote the paper: FS HR. Synthesized cAMP analogues: FS. Performed the in vitro PKA activation assays: DB. Performed the insulin secretion assays: CNL JHE. Prepared and contributed human pancreas: JHE EJPK. Collected X-ray diffraction data: MAH. Performed and analyzed NMR experiments: HW. Wrote grants: JLB.