Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases

Lilian T. Lamech; Anna L. Mallam; Alan M. Lambowitz

doi:10.1371/journal.pbio.1002028

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Open Access

Peer-reviewed

Research Article

Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases

Lilian T. Lamech,

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America
⨯
Anna L. Mallam,

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America
⨯
Alan M. Lambowitz

* E-mail: lambowitz@austin.utexas.edu

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America
⨯

Evolution of RNA-Protein Interactions: Non-Specific Binding Led to RNA Splicing Activity of Fungal Mitochondrial Tyrosyl-tRNA Synthetases

Lilian T. Lamech,
Anna L. Mallam,
Alan M. Lambowitz

Published: December 23, 2014
https://doi.org/10.1371/journal.pbio.1002028

About the Authors

Lilian T. Lamech

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

Anna L. Mallam

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

Alan M. Lambowitz

* E-mail: lambowitz@austin.utexas.edu

Affiliation The Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LTL AML. Performed the experiments: LTL. Analyzed the data: LTL ALM AML. Wrote the paper: LTL ALM AML.

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Introns
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RNA splicing
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RNA structure
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RNA-binding proteins
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Small-angle scattering
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Ribozymes
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Fungal evolution
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Molecular evolution
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