About the Authors

Danian Chen

Affiliations Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada , Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada , Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

Rene Opavsky

Affiliations Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America , Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America , Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

Marek Pacal

Affiliations Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada , Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada , Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

Naoyuki Tanimoto

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Germany

Pamela Wenzel

Affiliations Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America , Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America , Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

Mathias W Seeliger

Affiliation Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tuebingen, Germany

Gustavo Leone

Affiliations Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, United States of America , Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America , Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America

Rod Bremner

To whom correspondence should be addressed. E-mail: rbremner@uhnres.utoronto.ca

Affiliations Genetics and Development Division, Toronto Western Research Institute, University Health Network, University of Toronto, Ontario, Canada , Department of Ophthalmology and Visual Science, University of Toronto, Ontario, Canada , Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DC and RB conceived and designed the experiments. DC performed most of the experiments. RO, PW, and GL provided the E2f3 floxed and E2f3a KO mice. DC and RB analyzed the data. MP, NT, and MWS performed the ERG analysis. DC and RB wrote the paper.