Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes

Yi Fang; Ning Wu; Xin Gan; Wanhua Yan; James C Morrell; Stephen J Gould

doi:10.1371/journal.pbio.0050158

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Open Access

Peer-reviewed

Research Article

Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes

Yi Fang,

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Ning Wu,

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Xin Gan,

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Wanhua Yan,

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
James C Morrell,

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Stephen J Gould

*To whom correspondence should be addressed. E-mail: sgould@jhmi.edu

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Higher-Order Oligomerization Targets Plasma Membrane Proteins and HIV Gag to Exosomes

Yi Fang,
Ning Wu,
Xin Gan,
Wanhua Yan,
James C Morrell,
Stephen J Gould

Published: June 5, 2007
https://doi.org/10.1371/journal.pbio.0050158

About the Authors

Yi Fang

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Ning Wu

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Xin Gan

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Wanhua Yan

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

James C Morrell

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Stephen J Gould

*To whom correspondence should be addressed. E-mail: sgould@jhmi.edu

Affiliation Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YF, NW, and SJG conceived and designed the experiments. YF, NW, XG, WY, and JCM performed the experiments. YF, NW, XG, and SJG analyzed the data. YF and SJG wrote the paper.

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HIV
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Exosomes
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Membrane proteins
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T cells
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Cell membranes
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Biosynthesis
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Immunoblotting
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Vesicles
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