About the Authors
- José M Ranz
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*To whom correspondence should be addressed. E-mail: jmr68@mole.bio.cam.ac.uk
Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- Damien Maurin
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Current address: Laboratory of Enzymology at Interfaces and Physiology of Lipolysis, CNRS, UPR 9025, Marseille, France
Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- Yuk S Chan
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Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- Marcin von Grotthuss
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Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- LaDeana W Hillier
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Affiliation Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America
- John Roote
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Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- Michael Ashburner
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Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
- Casey M Bergman
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Current address: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Affiliation Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
JMR and JR devised the characterization of the breakpoint regions of the inversion In(3R)84F1;93F6–7 in D. melanogaster, D. simulans, and D. yakuba. LWH was responsible for curation and generation of the D. yakuba and D. simulans assemblies and chromosomal assignments, ordering, and orientation (including developing methods for comparative alignments and introducing appropriate inversions for creation of the chromosomal files). CMB conceived of and performed the genome-wide mapping of D. melanogaster genes against D. yakuba to detect breakpoint regions and verified breakpoint regions using UCSC whole-genome alignment. JMR participated in all the in silico and in vivo comparative analyses with the support of DM and with specific contributions by YSC, MvG, LWH, MA, and CMB. JMR, MA and CMB wrote the paper.