About the Authors

Bente Vestergaard

Contributed equally to this work with: Bente Vestergaard, Minna Groenning

To whom correspondence should be addressed. E-mail: bv@farma.ku.dk (BV); svergun@embl-hamburg.de (DIS)

Affiliation Department of Medicinal Chemistry, University of Copenhagen, Copenhagen, Denmark

Minna Groenning

Contributed equally to this work with: Bente Vestergaard, Minna Groenning

Affiliations Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark , Biophysics, Novo Nordisk A/S, Bagsvaerd, Denmark

Manfred Roessle

Affiliation Hamburg Outstation, European Molecular Biology Laboratory, Hamburg, Germany

Jette S Kastrup

Affiliation Department of Medicinal Chemistry, University of Copenhagen, Copenhagen, Denmark

Marco van de Weert

Affiliation Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark

James M Flink

Affiliation Biophysics, Novo Nordisk A/S, Bagsvaerd, Denmark

Sven Frokjaer

Affiliation Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark

Michael Gajhede

Affiliation Department of Medicinal Chemistry, University of Copenhagen, Copenhagen, Denmark

Dmitri I Svergun

To whom correspondence should be addressed. E-mail: bv@farma.ku.dk (BV); svergun@embl-hamburg.de (DIS)

Affiliations Hamburg Outstation, European Molecular Biology Laboratory, Hamburg, Germany , Institute of Crystallography, Russian Academy of Sciences, Moscow, Russia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

B. Vestergaard, M. Groenning, M. van de Weert, and S. Frokjaer conceived and designed the experiments. B. Vestergaard, M. Groenning, M. Roessle, and D. I. Svergun performed the experiments. B. Vestergaard, M. Groenning, M. Roessle, J. S, Kastrup, J. M. Flink, M. Gajhede, and D. I. Svergun analyzed the data. B. Vestergaard, M. van de Weert, J. M. Flink, S. Frokjaer, M. Gajhede, and D. I. Svergun contributed reagents/materials/analysis tools. B. Vestergaard, M. Groenning, J. S, Kastrup, and D. I. Svergun wrote the paper.