Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms

P. J Hastings; Andrew Slack; Joseph F Petrosino; Susan M Rosenberg

doi:10.1371/journal.pbio.0020399

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Peer-reviewed

Research Article

Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms

P. J Hastings ,

*To whom correspondence should be addressed. E-mail: hastings@bcm.tmc.edu

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Andrew Slack,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Joseph F Petrosino,

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Susan M Rosenberg

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms

P. J Hastings,
Andrew Slack,
Joseph F Petrosino,
Susan M Rosenberg

Published: November 23, 2004
https://doi.org/10.1371/journal.pbio.0020399

About the Authors

P. J Hastings

*To whom correspondence should be addressed. E-mail: hastings@bcm.tmc.edu

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Andrew Slack

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Joseph F Petrosino

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Susan M Rosenberg

Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

PH and SMR conceived and designed the experiments. PH, AS, and JFP performed the experiments. PH, AS, and JFP analyzed the data. SMR contributed reagents/materials/analysis tools. PH and SMR wrote the paper.

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