A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity

Chung-I Chang; Sébastien Pili-Floury; Mireille Hervé; Claudine Parquet; Yogarany Chelliah; Bruno Lemaitre; Dominique Mengin-Lecreulx; Johann Deisenhofer

doi:10.1371/journal.pbio.0020277

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Peer-reviewed

Research Article

A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity

Chung-I Chang,

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Sébastien Pili-Floury,

Affiliation Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
⨯
Mireille Hervé,

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France
⨯
Claudine Parquet,

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France
⨯
Yogarany Chelliah,

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Bruno Lemaitre,

Affiliation Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
⨯
Dominique Mengin-Lecreulx ,

*To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France
⨯
Johann Deisenhofer

*To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
⨯

A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity

Chung-I Chang,
Sébastien Pili-Floury,
Mireille Hervé,
Claudine Parquet,
Yogarany Chelliah,
Bruno Lemaitre,
Dominique Mengin-Lecreulx,
Johann Deisenhofer

Published: September 7, 2004
https://doi.org/10.1371/journal.pbio.0020277

About the Authors

Chung-I Chang

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Sébastien Pili-Floury

Affiliation Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

Mireille Hervé

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

Claudine Parquet

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

Yogarany Chelliah

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Bruno Lemaitre

Affiliation Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

Dominique Mengin-Lecreulx

*To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

Affiliation Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

Johann Deisenhofer

*To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

Affiliation Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

CIC, BL, and DML conceived and designed the experiments. CIC, SPF, BL, and DML performed the experiments. CIC, SPF, BL, DML, and JD analyzed the data. MH, CP, and YC contributed reagents/materials/analysis tools. CIC, BL, DML, and JD wrote the paper.

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Pattern recognition receptors
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Drosophila melanogaster
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Crystal structure
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Gram positive bacteria
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Signal peptides
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Bacterial diseases
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Mutational analysis
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Peptidoglycans
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