A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

Bing-Hao Luo; Timothy A Springer; Junichi Takagi

doi:10.1371/journal.pbio.0020153

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Open Access

Peer-reviewed

Research Article

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

Bing-Hao Luo,

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Timothy A Springer ,

*To whom correspondence should be addressed. E-mail: springeroffice@cbr.med.harvard.edu

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Junichi Takagi

Current address: Institute for Protein Research, Laboratory of Protein Synthesis and Expression, Osaka University, Osaka, Japan

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

Bing-Hao Luo,
Timothy A Springer,
Junichi Takagi

Published: June 15, 2004
https://doi.org/10.1371/journal.pbio.0020153

About the Authors

Bing-Hao Luo

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Timothy A Springer

*To whom correspondence should be addressed. E-mail: springeroffice@cbr.med.harvard.edu

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Junichi Takagi

Current address: Institute for Protein Research, Laboratory of Protein Synthesis and Expression, Osaka University, Osaka, Japan

Affiliation Center for Blood Research (CBR) Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JT and TAS conceived and designed the experiments. B-HL and JT performed the experiments. B-HL, JT, and TAS analyzed the data. B-HL, JT, and TAS wrote the paper.

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Integrins
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Disulfide bonds
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Cysteine
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Oxidation
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Cell membranes
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Alpha helix
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Cross-linking
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293T cells
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