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Macromolecular structure analysis

Ononin delays the development of osteoarthritis by down-regulating MAPK and NF-κB pathways in rat models

Fang Xu, Zhaocong Li, Yueming Jiang, Ting Liao, Michael Aschner, Qingjun Wei

published 31 Oct 2024

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A physically inspired approach to coarse-graining transcriptomes reveals the dynamics of aging

Tao Li, Madhav Mani

published 29 Oct 2024

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Identification of interaction partners of outer inflammatory protein A: Computational and experimental insights into how Helicobacter pylori infects host cells

Sümeyye Akcelik-Deveci, Elif Kılıç, Nesteren Mansur-Ozen, Emel Timucin, Yaren Buyukcolak, Sinem Oktem-Okullu

published 29 Oct 2024

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Design and antiviral assessment of a panel of fusion proteins targeting human papillomavirus type 16

Chongzhi Bai, Ruoyu Wang, Qian Yang, Jianqing Hao, Qiming Zhong, Ruiwen Fan, Pengcheng Han

published 25 Oct 2024

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The oral pathogen Porphyromonas gingivalis gains tolerance to the antimicrobial peptide DGL13K by synonymous mutations in hagA

Sven-Ulrik Gorr, Ruoqiong Chen, Juan E. Abrahante, Paul B. M. Joyce

published 24 Oct 2024

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Engineered red Opto-mGluR6 Opsins, a red-shifted optogenetic excitation tool, an in vitro study

Hoda Shamsnajafabadi, Zahra-Soheila Soheili, Mehdi Sadeghi, Shahram Samiee, Pouria Ghasemi, Mohammad Ismail Zibaii, Hamid Gholami Pourbadie, Hamid Ahmadieh, Ehsan Ranaei Pirmardan, Najmeh Salehi, Dorsa Samiee, Ali Kashanian

published 24 Oct 2024

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Demonstration of physicochemical and functional similarity between Stimufend (pegfilgrastim-fpgk) and Neulasta (pegfilgrastim): A comparative analytical assessment

Alison Sykes, Louise Ingram, Ulrich Kronthaler, Laurent Chevalet

published 24 Oct 2024

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Designing novel multiepitope mRNA vaccine targeting Hendra virus (HeV): An integrative approach utilizing immunoinformatics, reverse vaccinology, and molecular dynamics simulation

Ahmad Abdullah Mahdeen, Imam Hossain, Md. Habib Ullah Masum, Sajedul Islam, T. M. Fazla Rabbi

published 23 Oct 2024

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Examination of yield, bacteriolytic activity and cold storage of linker deletion mutants based on endolysin S6_ORF93 derived from Staphylococcus giant bacteriophage S6

Sosuke Munetomo, Jumpei Uchiyama, Iyo Takemura-Uchiyama, Thamonwan Wanganuttara, Yumiko Yamamoto, Toshihiro Tsukui, Hideharu Hagiya, Shuji Kanamaru, Hideyuki Kanda, Osamu Matsushita

published 23 Oct 2024

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Bioinformatics design of peptide binding to the human cardiac troponin I (cTnI) in biosensor development for myocardial infarction diagnosis

Muhammad Miftah Jauhar, Filasta Rachel Damairetha, Etik Mardliyati, Mokhamad Fakhrul Ulum, Putri Hawa Syaifie, Fahmi Fahmi, Ardianto Satriawan, Wervyan Shalannanda, Isa Anshori

published 22 Oct 2024

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Predictive immunoinformatics reveal promising safety and anti-onchocerciasis protective immune response profiles to vaccine candidates (Ov-RAL-2 and Ov-103) in anticipation of phase I clinical trials

Derrick Neba Nebangwa, Robert Adamu Shey, Daniel Madulu Shadrack, Cabirou Mounchili Shintouo, Ntang Emmaculate Yaah, Bernis Neneyoh Yengo, Mary Teke Efeti, Ketura Yaje Gwei, Darling Bih Aubierge Fomekong, Gordon Takop Nchanji, Arnaud Azonpi Lemoge, Fidele Ntie‑Kang, Stephen Mbigha Ghogomu

published 21 Oct 2024

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The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins

Xiaohui Liu, Yutaka Matsuyama, Makiko Sugiyama, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi

published 21 Oct 2024

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Combining metabolomics and machine learning to discover biomarkers for early-stage breast cancer diagnosis

Nguyen Ky Anh, Anbok Lee, Nguyen Ky Phat, Nguyen Thi Hai Yen, Nguyen Quang Thu, Nguyen Tran Nam Tien, Ho-Sook Kim, Tae Hyun Kim, Dong Hyun Kim, Hee-Yeon Kim, Nguyen Phuoc Long

published 21 Oct 2024

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