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Cell physiology

Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells

Yana Blokhina, Abigail Buchwalter

published 12 Dec 2024

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Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch

Yuki Aisu, Nobu Oshima, Fuminori Hyodo, Abdelazim Elsayed Elhelaly, Akihiko Masuo, Tomoaki Okada, Shigeo Hisamori, Shigeru Tsunoda, Koya Hida, Tomonori Morimoto, Hiroyuki Miyoshi, Makoto M. Taketo, Masayuki Matsuo, Leonard M. Neckers, Yoshiharu Sakai, Kazutaka Obama

published 12 Dec 2024

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HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption

Kaiyi Zhou, Siyu Luo, Qinxiao Wang, Qian Ye, Sheng Fang

published 05 Dec 2024

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GC-MS metabolite profiling of Pseudocercospora fijiensis isolates resistant to thiabendazole

María Gabriela Maridueña-Zavala, Pablo Antonio Chong-Aguirre, Andrea Freire-Peñaherrera, Arturo Moreno, José Ignacio Reyes-De-Corcuera, María Isabel Jiménez-Feijoo, Juan Manuel Cevallos-Cevallos

published 21 Nov 2024

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Phagolysosomes break down the membrane of a non-apoptotic corpse independent of macroautophagy

Shruti Kolli, Cassidy J. Kline, Kimya M. Rad, Ann M. Wehman

published 21 Nov 2024

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EasyFlow: An open-source, user-friendly cytometry analyzer with graphic user interface (GUI)

Yitong Ma, Inbal Eizenberg-Magar, Yaron Antebi

published 13 Nov 2024

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An automated high-content screening and assay platform for the analysis of spheroids at subcellular resolution

Margaritha M. Mysior, Jeremy C. Simpson

published 12 Nov 2024

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Inhibition of the miR-1914-5p increases the oxidative metabolism in cellular model of steatosis by modulating the Sirt1-PGC-1α pathway and systemic cellular activity

Thais Porto-Barbosa, Letícia Ferreira Ramos, Camila Cristiane Pansa, Letícia Ramos Molica, Osmar Malaspina, Karen C. M. Moraes

published 08 Nov 2024

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The shared biomarkers and immune landscape in psoriatic arthritis and rheumatoid arthritis: Findings based on bioinformatics, machine learning and single-cell analysis

Kaiyi Zhou, Siyu Luo, Qinxiao Wang, Sheng Fang

published 07 Nov 2024

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Visualizing VDAC1 in live cells using a tetracysteine tag

Johannes Pilic, Furkan E. Oflaz, Benjamin Gottschalk, Yusuf C. Erdogan, Wolfgang F. Graier, Roland Malli

published 18 Oct 2024

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TFAB002s, novel CD20-targeting T cell-dependent bispecific Fab-FabCH3 antibodies, exhibit potent antitumor efficacy against malignant B-cell lymphoma

Qinghong Li, Kunming Zhang, Yao Yu, Zeng Yu, Jingyi Xu, Wenyan Shen, Lin Zhang, Aidong Qu, Hongyuan Liang

published 25 Sep 2024

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Glutathione transferase P1 is modified by palmitate

Vanessa Marensi, Megan C. Yap, Yuhuan Ji, Cheng Lin, Luc G. Berthiaume, Elaine M. Leslie

published 13 Sep 2024

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The final walk with preptin

Lucie Mrázková, Marta Lubos, Jan Voldřich, Erika Kužmová, Denisa Zrubecká, Petra Gwozdiaková, Miloš Buděšínský, Seiya Asai, Aleš Marek, Jan Pícha, Michaela Tencerová, Michaela Ferenčáková, Glenda Alquicer Barrera, Jakub Kaminský, Jiří Jiráček, Lenka Žáková

published 12 Sep 2024

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