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May 2019

Communally grazed cattle on the tropical lowland Pongolo River floodplain in northern KwaZulu-Natal, South Africa, live in a rich and complex ecosystem together with humans, other livestock, wildlife, parasites, vectors and pathogens, including the mosquito-transmitted Rift Valley fever virus. Van den Bergh et al. (2019)

Image Credit: Peter Thompson

Viewpoints

Pediatric tropical medicine: The neglected diseases of children

Peter J. Hotez, Audrey R. Odom John, A. Desiree LaBeaud

Antibacterial mass drug administration for child mortality reduction: Opportunities, concerns, and possible next steps

Isaac I. Bogoch, Jürg Utzinger, Nathan C. Lo, Jason R. Andrews

Policy Platform

The case for paracoccidioidomycosis to be accepted as a neglected tropical (fungal) disease

Joshua Griffiths, Arnaldo Lopes Colombo, David W. Denning

Symposium

Chaetomium atrobrunneum causing human eumycetoma: The first report

Najwa A. Mhmoud, Antonella Santona, Maura Fiamma, Emmanuel Edwar Siddig, Massimo Deligios, Sahar Mubarak Bakhiet, Salvatore Rubino, Ahmed Hassan Fahal

Review

Functional genomics in sand fly–derived Leishmania promastigotes

Pedro J. Alcolea, Ana Alonso, Ricardo Molina, Maribel Jiménez, Peter J. Myler, Vicente Larraga

Research Articles

Detection of clinical and neurological signs in apparently asymptomatic HTLV-1 infected carriers: Association with high proviral load

Michel E. Haziot, M. Rita Gascon, Tatiane Assone, Luiz Augusto M. Fonseca, Olinda do Carmo Luiz, Jerusa Smid, Arthur M. Paiva, Rosa Maria do N. Marcusso, A. C. Penalva de Oliveira, Jorge Casseb

Molecular detection of P. vivax and P. ovale foci of infection in asymptomatic and symptomatic children in Northern Namibia

Daniel H. Haiyambo, Petrina Uusiku, Davies Mumbengegwi, Jeff M. Pernica, Ronnie Bock, Benoit Malleret, Laurent Rénia, Beatrice Greco, Isaac K. Quaye

Unbiased assessment of disease surveillance utilities: A prospect theory application

Arthur E. Attema, Lisheng He, Alasdair J. C. Cook, Victor J. Del Rio Vilas

Biodegradable nanocarriers coated with polymyxin B: Evaluation of leishmanicidal and antibacterial potential

Juliana Souza Ribeiro Costa, Marília Medeiros, Edite Harumi Yamashiro-Kanashiro, Mussya Cisotto Rocha, Paulo Cesar Cotrim, Marco Antonio Stephano, Marcelo Lancellotti, Guilherme Diniz Tavares, Laura Oliveira-Nascimento

Topical paromomycin for New World cutaneous leishmaniasis

Néstor Sosa, Juan Miguel Pascale, Ana I. Jiménez, Jeanne A. Norwood, Mara Kreishman-Detrick, Peter J. Weina, Kendra Lawrence, William F. McCarthy, Ryan C. Adams, Charles Scott, Janet Ransom, Douglas Tang, Max Grogl

Knowledge, attitudes and practices related to schistosomiasis transmission and control in Leyte, Philippines

Isabel Francisco, Mario Jiz, Marieke Rosenbaum, Palmera Baltazar, Jennifer A. Steele

High seroconversion rate to Rift Valley fever virus in cattle and goats in far northern KwaZulu-Natal, South Africa, in the absence of reported outbreaks

Carien van den Bergh, Estelle H. Venter, Robert Swanepoel, Peter N. Thompson

Effects of water, sanitation, handwashing and nutritional interventions on soil-transmitted helminth infections in young children: A cluster-randomized controlled trial in rural Bangladesh

Ayse Ercumen, Jade Benjamin-Chung, Benjamin F. Arnold, Audrie Lin, Alan E. Hubbard, Christine Stewart, Zahidur Rahman, Sarker Masud Parvez, Leanne Unicomb, Mahbubur Rahman, Rashidul Haque, John M. Colford Jr., Stephen P. Luby

Animal model of arthritis and myositis induced by the Mayaro virus

Franciele Martins Santos, Roberto Sousa Dias, Michelle Dias de Oliveira, Isabella Cristina Toledo Alves Costa, Luciana de Souza Fernandes, Carine Ribeiro Pessoa, Sérgio Luis Pinto da Matta, Vivian Vasconcelos Costa, Danielle G. Souza, Cynthia Canêdo da Silva, Sérgio Oliveira de Paula

A 5-Year intervention study on elimination of urogenital schistosomiasis in Zanzibar: Parasitological results of annual cross-sectional surveys

Stefanie Knopp, Shaali M. Ame, Bobbie Person, Jan Hattendorf, Muriel Rabone, Saleh Juma, Juma Muhsin, Iddi Simba Khamis, Elizabeth Hollenberg, Khalfan A. Mohammed, Fatma Kabole, Said M. Ali, David Rollinson

Arboviral screening of invasive Aedes species in northeastern Turkey: West Nile virus circulation and detection of insect-only viruses

Mustafa M. Akıner, Murat Öztürk, Aykut Buğra Başer, Filiz Günay, Sabri Hacıoğlu, Annika Brinkmann, Nergis Emanet, Bülent Alten, Aykut Özkul, Andreas Nitsche, Yvonne-Marie Linton, Koray Ergünay

Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis

Bruno Cesar Bremer Hinckel, Tegwen Marlais, Stephanie Airs, Tapan Bhattacharyya, Hideo Imamura, Jean-Claude Dujardin, Sayda El-Safi, Om Prakash Singh, Shyam Sundar, Andrew Keith Falconar, Bjorn Andersson, Sergey Litvinov, Michael A. Miles, Pascal Mertens

Seasonal patterns of dengue fever in rural Ecuador: 2009-2016

Rachel Sippy, Diego Herrera, David Gaus, Ronald E. Gangnon, Jonathan A. Patz, Jorge E. Osorio

Hindgut microbiota in laboratory-reared and wild Triatoma infestans

Andreea Waltmann, Alexandra C. Willcox, Sujata Balasubramanian, Katty Borrini Mayori, Sandra Mendoza Guerrero, Renzo S. Salazar Sanchez, Jeffrey Roach, Carlos Condori Pino, Robert H. Gilman, Caryn Bern, Jonathan J. Juliano, Michael Z. Levy, Steven R. Meshnick, Natalie M. Bowman

Characterization of a non-sexual population of Strongyloides stercoralis with hybrid 18S rDNA haplotypes in Guangxi, Southern China

Siyu Zhou, Xiaoyin Fu, Pei Pei, Marek Kucka, Jing Liu, Lili Tang, Tingzheng Zhan, Shanshan He, Yingguang Frank Chan, Christian Rödelsperger, Dengyu Liu, Adrian Streit

PCR-RFLP analyses of Leishmania species causing cutaneous and mucocutaneous leishmaniasis revealed distribution of genetically complex strains with hybrid and mito-nuclear discordance in Ecuador

Hirotomo Kato, Eduardo A. Gomez, Chisato Seki, Hayato Furumoto, Luiggi Martini-Robles, Jenny Muzzio, Manuel Calvopiña, Lenin Velez, Makoto Kubo, Ahmed Tabbabi, Daisuke S. Yamamoto, Yoshihisa Hashiguchi

Endoparasites and vector-borne pathogens in dogs from Greek islands: Pathogen distribution and zoonotic implications

Anastasia Diakou, Angela Di Cesare, Simone Morelli, Mariasole Colombo, Lenaig Halos, Giulia Simonato, Androniki Tamvakis, Frederic Beugnet, Barbara Paoletti, Donato Traversa

A computational method for the identification of Dengue, Zika and Chikungunya virus species and genotypes

Vagner Fonseca, Pieter J. K. Libin, Kristof Theys, Nuno R. Faria, Marcio R. T. Nunes, Maria I. Restovic, Murilo Freire, Marta Giovanetti, Lize Cuypers, Ann Nowé, Ana Abecasis, Koen Deforche, Gilberto A. Santiago, Isadora C. de Siqueira, Emmanuel J. San, Kaliane C. B. Machado, Vasco Azevedo, Ana Maria Bispo-de Filippis, Rivaldo Venâncio da Cunha, Oliver G. Pybus, Anne-Mieke Vandamme, Luiz C. J. Alcantara, Tulio de Oliveira

Comparative accuracy of typhoid diagnostic tools: A Bayesian latent-class network analysis

Paul Arora, Kristian Thorlund, Darren R. Brenner, Jason R. Andrews

Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei

Amy K. Dickey, Narisara Chantratita, Sarunporn Tandhavanant, Deirdre Ducken, Lara Lovelace-Macon, Sudeshna Seal, Johanna Robertson, Nicolle D. Myers, Sandra Schwarz, Mark M. Wurfel, Susanna Kosamo, T. Eoin West

Cinnamomum cassia exhibits antileishmanial activity against Leishmania donovani infection in vitro and in vivo

Farhat Afrin, Garima Chouhan, Mohammad Islamuddin, Muzamil Y. Want, Hani A. Ozbak, Hassan A. Hemeg

Modelling population dynamics and seasonal movement to assess and predict the burden of melioidosis

Wiriya Mahikul, Lisa J. White, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Pataporn Sukontamarn, Phetsavanh Chanthavilay, Graham F. Medley, Wirichada Pan-ngum

Provision of deworming intervention to pregnant women by antenatal services in countries endemic for soil-transmitted helminthiasis

Mathieu Bangert, Pilar Bancalari, Denise Mupfasoni, Alexei Mikhailov, Albis F. Gabrielli, Antonio Montresor

Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients

Tushar Shaw, Chaitanya Tellapragada, Asha Kamath, Vandana Kalwaje Eshwara, Chiranjay Mukhopadhyay

In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination

Javier Sotillo, Mark S. Pearson, Luke Becker, Gebeyaw G. Mekonnen, Abena S. Amoah, Govert van Dam, Paul L. A. M. Corstjens, Janice Murray, Takafira Mduluza, Francisca Mutapi, Alex Loukas

A 15-year review of dengue hospitalizations in Singapore: Reducing admissions without adverse consequences, 2003 to 2017

Li Wei Ang, Tun-Linn Thein, Yixiang Ng, Irving Charles Boudville, Po Ying Chia, Vernon Jian Ming Lee, Yee-Sin Leo

Interplay between proinflammatory cytokines, miRNA, and tissue lesions in Anisakis-infected Sprague-Dawley rats

Jerko Hrabar, Željka Trumbić, Ivana Bočina, Ivana Bušelić, Anamarija Vrbatović, Ivona Mladineo

Malaria vector species in Amazonian Peru co-occur in larval habitats but have distinct larval microbial communities

Catharine Prussing, Marlon P. Saavedra, Sara A. Bickersmith, Freddy Alava, Mitchel Guzmán, Edgar Manrique, Gabriel Carrasco-Escobar, Marta Moreno, Dionicia Gamboa, Joseph M. Vinetz, Jan E. Conn

Prevalence, intensity and risk factors of tungiasis in Kilifi County, Kenya II: Results from a school-based observational study

Lynne Elson, Susanne Wiese, Hermann Feldmeier, Ulrike Fillinger

Genome sequencing reveals coinfection by multiple chikungunya virus genotypes in a recent outbreak in Brazil

Lais Ceschini Machado, Mariana Carolina de Morais-Sobral, Tulio de Lima Campos, Mylena Ribeiro Pereira, Maria de Fátima Pessoa Militão de Albuquerque, Clément Gilbert, Rafael Freitas Oliveira Franca, Gabriel Luz Wallau

The most abundant cyst wall proteins of Acanthamoeba castellanii are lectins that bind cellulose and localize to distinct structures in developing and mature cyst walls

Pamela Magistrado-Coxen, Yousuf Aqeel, Angelo Lopez, John R. Haserick, Breeanna R. Urbanowicz, Catherine E. Costello, John Samuelson

Imported strongyloidiasis: Data from 1245 cases registered in the +REDIVI Spanish Collaborative Network (2009-2017)

Fernando Salvador, Begoña Treviño, Sandra Chamorro-Tojeiro, Adrián Sánchez-Montalvá, Juan María Herrero-Martínez, Azucena Rodríguez-Guardado, Núria Serre-Delcor, Diego Torrús, Josune Goikoetxea, Zuriñe Zubero, María Velasco, Elena Sulleiro, Israel Molina, Rogelio López-Vélez, José Antonio Pérez-Molina, on behalf the +REDIVI Collaborative Network

Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase

Zhe Cheng, Fan Liu, Huimin Tian, Zhijian Xu, Xiaoli Chai, Damin Luo, Yanhai Wang

The characteristics of current natural foci of hemorrhagic fever with renal syndrome in Shandong Province, China, 2012-2015

Zhaolei Zheng, Peizhu Wang, Zhiqiang Wang, Dandan Zhang, Xu Wang, Shuqing Zuo, Xiujun Li

The prevalence of Leptospira among invasive small mammals on Puerto Rican cattle farms

Kathryn M. Benavidez, Trina Guerra, Madison Torres, David Rodriguez, Joseph A. Veech, Dittmar Hahn, Robert J. Miller, Fred V. Soltero, Alejandro E. Pérez Ramírez, Adalberto Perez de León, Iván Castro-Arellano

Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A

Tiffany Y. Borbón, Breanna M. Scorza, Gwendolyn M. Clay, Fellipe Lima Nobre de Queiroz, Alan J. Sariol, Jayden L. Bowen, Yani Chen, Bayan Zhanbolat, Corey P. Parlet, Diogo G. Valadares, Suzanne L. Cassel, William M. Nauseef, Alexander R. Horswill, Fayyaz S. Sutterwala, Mary E. Wilson

Molecular characterization of Brucella species from Zimbabwe

Maphuti Betty Ledwaba, Calvin Gomo, Kgaugelo Edward Lekota, Philippe Le Flèche, Ayesha Hassim, Gilles Vergnaud, Henriette van Heerden

Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Côte d’Ivoire

Constant Edi, Catherine M. Bjerum, Allassane F. Ouattara, Yashpal S. Chhonker, Louis K. Penali, Aboulaye Méité, Benjamin G. Koudou, Gary J. Weil, Christopher L. King, Daryl J. Murry

Effects of ‘The Vicious Worm’ educational tool on Taenia solium knowledge retention in Zambian primary school students after one year

Emma C. Hobbs, Kabemba Evans Mwape, Brecht Devleesschauwer, Inge Van Damme, Meryam Krit, Dirk Berkvens, Gideon Zulu, Moses Mambwe, Mwelwa Chembensofu, Chiara Trevisan, Jacoba Baauw, Isaac Khozozo Phiri, Niko Speybroeck, Jennifer Ketzis, Pierre Dorny, Arve Lee Willingham, Sarah Gabriël

El Niño Southern Oscillation, overseas arrivals and imported chikungunya cases in Australia: A time series analysis

Xiaodong Huang, Wenbiao Hu, Laith Yakob, Gregor J. Devine, Elizabeth A. McGraw, Cassie C. Jansen, Helen M. Faddy, Francesca D. Frentiu

Sexual reproduction in a natural Trypanosoma cruzi population

Alexander S. F. Berry, Renzo Salazar-Sánchez, Ricardo Castillo-Neyra, Katty Borrini-Mayorí, Claudia Chipana-Ramos, Melina Vargas-Maquera, Jenny Ancca-Juarez, César Náquira-Velarde, Michael Z. Levy, Dustin Brisson, the Chagas Disease Working Group in Arequipa

Trypanosoma cruzi surface mucins are involved in the attachment to the Triatoma infestans rectal ampoule

María de los Milagros Cámara, Virginia Balouz, Camila Centeno Cameán, Carmen R. Cori, Gustavo A. Kashiwagi, Santiago A. Gil, Natalia Paula Macchiaverna, Marta Victoria Cardinal, Francisco Guaimas, Maite Mabel Lobo, Rosa M. de Lederkremer, Carola Gallo-Rodriguez, Carlos A. Buscaglia

Characterization of a yeast interfering RNA larvicide with a target site conserved in the synaptotagmin gene of multiple disease vector mosquitoes

Keshava Mysore, Ping Li, Chien-Wei Wang, Limb K. Hapairai, Nicholas D. Scheel, Jacob S. Realey, Longhua Sun, Joseph B. Roethele, David W. Severson, Na Wei, Molly Duman-Scheel

Pathogen blocking in Wolbachia-infected Aedes aegypti is not affected by Zika and dengue virus co-infection

Eric P. Caragata, Marcele N. Rocha, Thiago N. Pereira, Simone B. Mansur, Heverton L. C. Dutra, Luciano A. Moreira

A bioeconomic model for the optimization of local canine rabies control

Aaron Anderson, Johann Kotzé, Stephanie A. Shwiff, Brody Hatch, Chris Slootmaker, Anne Conan, Darryn Knobel, Louis H. Nel

Revisiting the taxonomy and evolution of pathogenicity of the genus Leptospira through the prism of genomics

Antony T. Vincent, Olivier Schiettekatte, Cyrille Goarant, Vasantha Kumari Neela, Eve Bernet, Roman Thibeaux, Nabilah Ismail, Mohd Khairul Nizam Mohd Khalid, Fairuz Amran, Toshiyuki Masuzawa, Ryo Nakao, Anissa Amara Korba, Pascale Bourhy, Frederic J. Veyrier, Mathieu Picardeau

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