Journal Information

The first journal solely devoted to the world’s most neglected tropical diseases, PLOS Neglected Tropical Diseases publishes leading research and commentary on all scientific, medical, political and public health aspects of forgotten diseases affecting the world’s most neglected people.


PLOS Neglected Tropical Diseases publishes research devoted to the pathology, epidemiology, prevention, treatment and control of the neglected tropical diseases (NTDs), as well as relevant public policy.

The NTDs are defined as a group of poverty-promoting chronic infectious diseases, which primarily occur in rural areas and poor urban areas of low-income and middle-income countries. Their impact on child health and development, pregnancy, and worker productivity, as well as their stigmatizing features limit economic stability.

All aspects of these diseases are considered, including:

  • Pathogenesis
  • Clinical features
  • Pharmacology and treatment
  • Diagnosis
  • Epidemiology
  • Vector biology
  • Vaccinology and prevention
  • Demographic, ecological and social determinants
  • Public health and policy aspects (including cost-effectiveness analyses)

The journal focuses on human disease, not infections that only afflict livestock and other animals unless these diseases also impact human health and represent a public health problem. Further, we would like to reiterate that the focus of our journal is on translational or epidemiological studies, and less so on pure, basic molecular research not associated with the improvement of human health.

Major NTDs within scope

Protozoan Infections (and their vectors)
  • Amebiasis including Naegleria
  • Babesiosis
  • Balantidiasis
  • Chagas Disease
  • Giardiasis
  • Human African Trypanosomiasis
  • Leishmaniasis
  • Plasmodium vivax and other non-P. falciparum malarias

On the cusp:**

  • Blastocystiasis*
  • Cryptosporidiosis and cyclosporiasis
  • Toxoplasmosis 

*The taxonomic position of the stramenopile-like, unicellular protist Blastocystis remains uncertain.

Helminth Infections (and their vectors)

All human helminth infections including but not restricted to:

  • Dracunculiasis
  • Echinococcosis
  • Food-borne Trematodiases
  • Loiasis
  • Lymphatic Filariasis
  • Onchocerciasis
  • Other food-borne helminthiases (Trichinosis, Anisakiasis, Gnathostomiasis)
  • Schistosomiasis
  • Soil-transmitted helminthiases (Ascariasis, Hookworm Diseases, Trichuriasis, Strongyloidiasis)
  • Taeniasis-Cysticercosis
  • Toxocariasis and other larva migrans (Baylisascaris)
Viral Infections (and their vectors)
  • Arboviral infections (Dengue, Chikungunya, Zika, Japanese encephalitis, Jungle yellow fever and others)
  • Enterovirus 71 and related viruses
  • HTLV-1, HTLV-2 and other non-HIV retrovirus infections
  • Rabies
  • Rift Valley fever
  • Viral hemorrhagic fevers

On the cusp:**

  • Henipavirus species e.g. Nipah virus
Bacterial Infections (and their vectors)
  • Bartonella
  • Bovine Tuberculosis in Humans
  • Buruli Ulcer
  • Cholera
  • Enteric pathogens (Shigella, Salmonella, E. coli)
  • Leprosy
  • Leptospirosis
  • Melioidosis
  • Noma (Orofacial Gangrene)
  • Relapsing Fever
  • Trachoma
  • Yaws and other tropical treponematoses (Bejel, Pinta)
  • Q fever

On the cusp:**

  • Group A Streptococcal disease
Fungal Infections
  • Mycetoma, chromoblastomycosis, and other deep mycoses

  • Paracoccidiomycosis

On the cusp:**

  • Cryptococcosis
  • Histoplasmosis
Ectoparasitic Infections
Scabies, Myiasis, and other ectoparasites
diseases or
  • Podoconiosis
  • Snakebite envenoming

On the cusp:**

  • Sickle-cell Anemia (only related to co-morbidity with an NTD in impoverished/ neglected populations)
**For NTDs on the cusp, submissions need to be clearly related to public health importance in a resource-poor setting.


Related topics with restricted scope

Nutritional diseases

Papers that examine the link between nutrition and NTD infection are considered for PLOS Neglected Tropical Diseases.

HIV/AIDS, malaria, and tuberculosis

The “big three” diseases, HIV/AIDS, malaria, and tuberculosis, are not generally considered for PLOS Neglected Tropical Diseases. Submit research on these diseases to one of the six other PLOS journals as appropriate.

Exception: The above three diseases are considered in the context of co-infections with the NTDs. For example, PLOS Neglected Tropical Diseases is interested in manuscripts that explore integrated control of the NTDs and the “big three” diseases. Additionally, PLOS Neglected Tropical Diseases considers manuscripts on all aspects of bovine tuberculosis affecting humans, and, on a case-by-case basis, on vivax malaria and related topics.

Fundamental microbial pathogenesis

Research on fundamental microbial pathogenesis and the molecular and cellular biology of the NTDs pathogens should be submitted to PLOS Pathogens. Examples: fundamental mechanisms of immune evasion by Plasmodium, blocking of apoptosis by Salmonella, population biology of Candida, or latency in herpes viruses.

Research on molecular pathways as potential drug or vaccine targets would be more suitable for PLOS Neglected Tropical Diseases.

Other research more suitable to PLOS Neglected Tropical Diseases includes health product (i.e., drug, diagnostic, and vaccine) development, human immunology, clinical manifestations, surveillance and epidemiologic research, public health control, and health policy aspects of the NTDs.

Other infections

Other infectious diseases will also be considered on a case-by-case basis.  Authors must indicate in the cover letter why they consider the infection to be a neglected tropical disease.



Original research

Research articles consider all aspects of the NTDs, including their pathogenesis, clinical features, pharmacology and treatment, diagnosis, epidemiology, vector biology, and vaccinology and prevention. Demographic, ecological and social determinants, public health, and policy aspects of these diseases (including cost-effectiveness analyses) are also a priority.

Magazine section

  • The Editorial is written by the Editor-in-Chief or a member of the Editorial Board.

  • The Viewpoints section contains opinion pieces grounded in evidence on topics of broad interest to the journal's readership.

  • The Policy Platform is for authors to discuss policies that could improve the lives of those at risk of, or affected by, the NTDs.

  • The Reviews section is for authors to summarize the best available evidence on a topic relevant to the NTD community.

  • In the Symposium section, authors discuss a “real world” problem, from the clinic, laboratory, or community, and how best it can be tackled.

Developing Countries

As part of its mission to widen the distribution of scientific literature, PLOS is particularly concerned with the disparities in access to information between developed and developing countries. PLOS provides immediate, free, and unrestricted access to all the scientific and medical literature that it publishes. In addition, PLOS is also dedicated to establishing a medium for publishing science from the developing world. Thus, a major goal of PLOS Neglected Tropical Diseases is to promote and profile the efforts of researchers, health practitioners, and public-health experts in endemic countries in order to help build science and health capacity in those regions.

PLOS Neglected Tropical Diseases offers the following means of support to authors in developing countries:

  • Publication fee assistance. Read more.

  • Editorial support. PLOS Neglected Tropical Diseases is organized to provide additional editorial support for authors in developing countries. Manuscripts that are accepted for publication will receive additional support from our editorial staff or professionals from our partner organizations.

  • International Editorial Board. About 40% of our Associate Editors—who handle peer review of research articles—are based in developing countries. These experts understand the issues involved in confronting these diseases in their endemic settings, and they will help to ensure that the journal is a voice for researchers in these countries. See the Editorial Board.

  • Worldwide readership. As an Open Access journal, PLOS Neglected Tropical Diseases articles will always be freely available online via the journal Web site as well as through PubMed Central. Our content license means that readers are free to download, print, distribute, and translate your work, provided that they give you credit and cite the source. This means that your work will have the broadest possible audience: the entire world. And recent studies suggest that Open Access articles are downloaded and cited more frequently.

  • Influence. Your research has the chance to be highly influential. Select papers about neglected tropical diseases published in PLOS journals have been downloaded many thousands of times, have been mentioned in international news sources, and have had an important impact on health policy. For example, a paper in PLOS Medicine led to a UN mandate to integrate control of the NTDs into the UN's malaria control efforts.

Criteria for Publication

To be considered for publication in PLOS Neglected Tropical Diseases, any given manuscript must satisfy the following criteria:

  • Originality

  • Importance and relevance to researchers, practitioners, or policy makers in the field of NTDs

  • Interest for researchers or practitioners outside the field

  • Rigorous methodology with conclusions justified by the evidence presented

  • Adherence to the highest ethical standards

Consideration of complementary research

Scientists commonly refer to research as “scooped” when independent groups working on the same topic reach similar conclusions and one group publishes the results first. Although originality is one criterion for studies published in PLOS Neglected Tropical Diseases, “scooped” manuscripts that confirm, replicate, extend, or are complementary to a recently published, significant advance are still eligible for consideration in PLOS Neglected Tropical Diseases. The complementary manuscript must present equally or more rigorous findings than the published study and any submission must also meet the criteria for publication listed above. Authors of the complementary work have six months after the first article’s publication date to submit their manuscript to PLOS Neglected Tropical Diseases. Studies must be performed comprehensively, and preliminary placeholder studies will not be considered.

Editorial Oversight

The editorial process is run as a partnership between the PLOS Neglected Tropical Diseases Editors-in-Chief, the board of Deputy Editors, and a team of academic experts who act as Associate Editors (AEs). These individuals, all of whom are members of the PLOS Neglected Tropical Diseases Editorial Board, are leaders in their fields and represent the full breadth of research on NTDs.


Shaden Kamhawi

Paul Brindley

Editorial Board

View the PLOS Neglected Tropical Diseases Editorial Board.

Submit Your Manuscript

For more information about submitting to PLOS Neglected Tropical Diseases, read our checklist for getting started and our guidelines for preparing a submission.


Publication Fees

PLOS Neglected Tropical Diseases publication fees vary based on article type and will be billed upon acceptance. Authors’ ability to pay publication fees will never be a consideration in the decision whether to publish. You can find a full list of our publication fees and fee assistance information here

Open Access

PLOS applies the Creative Commons Attribution (CC BY) license to works we publish. Under this license, authors agree to make articles legally available for reuse, without permission or fees, for virtually any purpose. Anyone may copy, distribute, or reuse these articles, as long as the author and original source are properly cited. Learn more.

Journal Impact and Article Metrics

PLOS does not consider Impact Factor to be a reliable or useful metric to assess the performance of individual articles. PLOS supports DORA – the San Francisco Declaration on Research Assessment – and does not promote our journal Impact Factors. We will provide the metric to individuals when specifically requested.

Read more about our pledge with DORA.

PLOS promotes the use of Article-Level Metrics (ALMs), which enable scientists and the general public to engage more dynamically with published research. ALMs reflect the changing impact of research over time, incorporate academic as well as social impacts of research, and assess the impact of research before the accrual of academic citations. Read more about ALMs.

Indexing and Archiving

See publishing details for all PLOS journal titles, including ISSN and indexing and archiving information.


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