April 2016

Taenia solium, a parasitic cestode that affects humans and pigs, is the leading cause of preventable epilepsy in the developing world. In this study, we used Global Positioning System (GPS) devices to track pig roaming ranges in two rural villages of northern Peru. Our aim was to describe the roaming ranges of pigs in this region, and to evaluate whether the 100 meter rings encompass areas where risk factors for T. solium transmission, such as open human defecation and dense pig activity, are concentrated. O'Neal et al.

Image Credit: Seth E O'Neal

Editorials

Nutritional Enteric Failure: Neglected Tropical Diseases and Childhood Stunting

Kirkby D. Tickell, Judd L. Walson

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004523

Neglected Tropical Diseases in the Anthropocene: The Cases of Zika, Ebola, and Other Infections

Peter J. Hotez

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004648

Viewpoints

Tsetse Control and the Elimination of Gambian Sleeping Sickness

Mike Lehane, Idriss Alfaroukh, Bruno Bucheton, Mamadou Camara, Angi Harris, Dramane Kaba, Crispin Lumbala, Mallaye Peka, Jean-Baptiste Rayaisse, Charles Waiswa, Philippe Solano, Steve Torr

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004437

Spread of the Invasive Mosquitoes Aedes aegypti and Aedes albopictus in the Black Sea Region Increases Risk of Chikungunya, Dengue, and Zika Outbreaks in Europe

Muhammet M. Akiner, Berna Demirci, Giorgi Babuadze, Vincent Robert, Francis Schaffner

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004664

Insecticidal Paints: A Realistic Approach to Vector Control?

Karin L. Schiøler, Michael Alifrangis, Uriel Kitron, Flemming Konradsen

PLOS Neglected Tropical Diseases: published April 21, 2016 | https://doi.org/10.1371/journal.pntd.0004518

Preventive Chemotherapy Versus Innovative and Intensified Disease Management in Neglected Tropical Diseases: A Distinction Whose Shelf Life Has Expired

Mark Rosenberg, Jürg Utzinger, David G. Addiss

PLOS Neglected Tropical Diseases: published April 14, 2016 | https://doi.org/10.1371/journal.pntd.0004521

Historical Profiles and Perspectives

Neglected Actors in Neglected Tropical Diseases Research: Historical Perspectives on Health Workers and Contemporary Buruli Ulcer Research in Ayos, Cameroon

Guillaume Lachenal, Joseph Owona Ntsama, Daniel Ze Bekolo, Thomas Kombang Ekodogo, John Manton

PLOS Neglected Tropical Diseases: published April 21, 2016 | https://doi.org/10.1371/journal.pntd.0004488

Symposiums

If It Looks Like a Duck, Swims Like a Duck, and Quacks Like a Duck—Does It Have to Be a Duck?

Damalie Nalwanga, Lars Henning

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004430

Adult Loa loa Filarial Worm in the Anterior Chamber of the Eye: A First Report from Savanna Belt of Northern Nigeria

Sadiq Hassan, Mohammed Isyaku, Abdulsalam Yayo, Farouq Sarkin Fada, Gabriel U. Ihesiulor, Garba Iliyasu

PLOS Neglected Tropical Diseases: published April 7, 2016 | https://doi.org/10.1371/journal.pntd.0004436

Acute Paracoccidioidomycosis Due to Paracoccidioides brasiliensis S1 Mimicking Hypereosinophilic Syndrome with Massive Splenomegaly: Diagnostic Challenge

Priscila Marques de Macedo, Luã Cardoso de Oliveira, Dayvison Francis Saraiva Freitas, Jaqueline Abel da Rocha, Andrea D’Ávila Freitas, Marcio Nucci, Rosely Maria Zancopé-Oliveira, Rodrigo Almeida-Paes, Antonio Carlos Francesconi do Valle

PLOS Neglected Tropical Diseases: published April 7, 2016 | https://doi.org/10.1371/journal.pntd.0004487

Review

Can Neglected Tropical Diseases Compromise Human Wellbeing in Sex-, Age-, and Trait-Specific Ways?

David C. Geary

PLOS Neglected Tropical Diseases: published April 14, 2016 | https://doi.org/10.1371/journal.pntd.0004489

Research Articles

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi

Linda J. Herrera, Stephen Brand, Andres Santos, Lilian L. Nohara, Justin Harrison, Neil R. Norcross, Stephen Thompson, Victoria Smith, Carolina Lema, Armando Varela-Ramirez, Ian H. Gilbert, Igor C. Almeida, Rosa A. Maldonado

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004540

A Deep Insight into the Sialome of Rhodnius neglectus, a Vector of Chagas Disease

Paula Beatriz Santiago, Teresa C. F. Assumpção, Carla Nunes de Araújo, Izabela Marques Dourado Bastos, David Neves, Ionizete Garcia da Silva, Sébastien Charneau, Rayner Myr L. Queiroz, Tainá Raiol, João Victor de Araújo Oliveira, Marcelo Valle de Sousa, Eric Calvo, José M. C. Ribeiro, Jaime M. Santana

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004581

Bayesian Spatiotemporal Pattern and Eco-climatological Drivers of Striped Skunk Rabies in the North Central Plains

Ram K. Raghavan, Cathleen A. Hanlon, Douglas G. Goodin, Rolan Davis, Michael Moore, Susan Moore, Gary A. Anderson

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004632

Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru

Eric S. Halsey, G. Christian Baldeviano, Kimberly A. Edgel, Stalin Vilcarromero, Moises Sihuincha, Andres G. Lescano

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004646

Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses

María G. Alvarez, Graciela L. Bertocchi, Gretchen Cooley, María C. Albareda, Rodolfo Viotti, Damián E. Perez-Mazliah, Bruno Lococo, Melisa Castro Eiro, Susana A. Laucella, Rick L. Tarleton

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004657

High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni

Nuha R. Mansour, Ross Paveley, J. Mark F. Gardner, Andrew S. Bell, Tanya Parkinson, Quentin Bickle

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004659

Underestimation of Leptospirosis Incidence in the French West Indies

Sylvie Cassadou, Jacques Rosine, Claude Flamand, Martina Escher, Martine Ledrans, Pascale Bourhy, Mathieu Picardeau, Philippe Quénel

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004668

Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer

Carlos Capela, Ange Dodji Dossou, Rita Silva-Gomes, Ghislain Emmanuel Sopoh, Michel Makoutode, João Filipe Menino, Alexandra Gabriel Fraga, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004671

Vestibular Evoked Myogenic Potential (VEMP) Triggered by Galvanic Vestibular Stimulation (GVS): A Promising Tool to Assess Spinal Cord Function in Schistosomal Myeloradiculopathy

Júlia Fonseca de Morais Caporali, Denise Utsch Gonçalves, Ludimila Labanca, Leonardo Dornas de Oliveira, Guilherme Vaz de Melo Trindade, Thiago de Almeida Pereira, Pedro Henrique Diniz Cunha, Marina Santos Falci Mourão, José Roberto Lambertucci

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004672

The Effect of Intestinal Parasitic Infection on the Clinical Outcome of Malaria in Coinfected Children in Cameroon

Tebit E. Kwenti, Franklin A. Nkume, Ajime T. Tanjeko, Tayong D. B. Kwenti

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004673

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

Miriam Bolz, Nicolas Ruggli, Nicole Borel, Gerd Pluschke, Marie-Thérèse Ruf

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004678

Predicting Dengue Fever Outbreaks in French Guiana Using Climate Indicators

Antoine Adde, Pascal Roucou, Morgan Mangeas, Vanessa Ardillon, Jean-Claude Desenclos, Dominique Rousset, Romain Girod, Sébastien Briolant, Philippe Quenel, Claude Flamand

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004681

Comprehensive Transcriptome Analysis of Sex-Biased Expressed Genes Reveals Discrete Biological and Physiological Features of Male and Female Schistosoma japonicum

Pengfei Cai, Shuai Liu, Xianyu Piao, Nan Hou, Geoffrey N. Gobert, Donald P. McManus, Qijun Chen

PLOS Neglected Tropical Diseases: published April 29, 2016 | https://doi.org/10.1371/journal.pntd.0004684

The Use of Assistive Technology to Promote Care of the Self and Social Inclusion in Patients with Sequels of Leprosy

Fátima Beatriz Maia, Enéas Rangel Teixeira, Gislaine Valeria Silva, Maria Katia Gomes

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004644

Behavioral Abnormalities in a Mouse Model of Chronic Toxoplasmosis Are Associated with MAG1 Antibody Levels and Cyst Burden

Jianchun Xiao, Ye Li, Emese Prandovszky, Geetha Kannan, Raphael P. Viscidi, Mikhail V. Pletnikov, Robert H. Yolken

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004674

Dermatophytosis among Schoolchildren in Three Eco-climatic Zones of Mali

Oumar Coulibaly, Abdoulaye K. Kone, Safiatou Niaré-Doumbo, Siaka Goïta, Jean Gaudart, Abdoulaye A. Djimdé, Renaud Piarroux, Ogobara K. Doumbo, Mahamadou A. Thera, Stéphane Ranque

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004675

The wMel Strain of Wolbachia Reduces Transmission of Chikungunya Virus in Aedes aegypti

Matthew T. Aliota, Emma C. Walker, Alexander Uribe Yepes, Ivan Dario Velez, Bruce M. Christensen, Jorge E. Osorio

PLOS Neglected Tropical Diseases: published April 28, 2016 | https://doi.org/10.1371/journal.pntd.0004677

Short Report: Serological Evidence of Under-Reported Dengue Circulation in Sierra Leone

Jaime M. de Araújo Lobo, Christopher N. Mores, Daniel G. Bausch, Rebecca C. Christofferson

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004613

An Innovative Field-Applicable Molecular Test to Diagnose Cutaneous Leishmania Viannia spp. Infections

Omar A. Saldarriaga, Alejandro Castellanos-Gonzalez, Renato Porrozzi, Gerald C. Baldeviano, Andrés G. Lescano, Maxy B. de Los Santos, Olga L. Fernandez, Nancy G. Saravia, Erika Costa, Peter C. Melby, Bruno L. Travi

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004638

A Survey of Dog Owners in Remote Northern Australian Indigenous Communities to Inform Rabies Incursion Planning

Emily G. Hudson, Navneet Dhand, Salome Dürr, Michael P. Ward

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004649

Diseases Neglected by the Media in Espírito Santo, Brazil in 2011–2012

Aline Guio Cavaca, Tatiana Breder Emerich, Paulo Roberto Vasconcellos-Silva, Edson Theodoro dos Santos-Neto, Adauto Emmerich Oliveira

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004662

Impact of Helminth Infection on the Clinical and Microbiological Presentation of Chagas Diseases in Chronically Infected Patients

Fernando Salvador, Elena Sulleiro, Adrián Sánchez-Montalvá, Mónica Martínez-Gallo, Eugenia Carrillo, Israel Molina

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004663

Inflammation Enhances the Risks of Stroke and Death in Chronic Chagas Disease Patients

Paulo Marcos Matta Guedes, Cléber Mesquita de Andrade, Daniela Ferreira Nunes, Nathalie de Sena Pereira, Tamyres Bernadete Dantas Queiroga, George Luiz Lins Machado-Coelho, Manuela Sales Lima Nascimento, Maria Adelaide Do-Valle-Matta, Antônia Cláudia Jácome da Câmara, Egler Chiari, Lúcia Maria da Cunha Galvão

PLOS Neglected Tropical Diseases: published April 26, 2016 | https://doi.org/10.1371/journal.pntd.0004669

Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae

Nicolas Pionnier, Emilie Brotin, Gregory Karadjian, Patrice Hemon, Françoise Gaudin-Nomé, Nathaly Vallarino-Lhermitte, Adélaïde Nieguitsila, Frédéric Fercoq, Marie-Laure Aknin, Viviana Marin-Esteban, Sylvie Chollet-Martin, Géraldine Schlecht-Louf, Françoise Bachelerie, Coralie Martin

PLOS Neglected Tropical Diseases: published April 25, 2016 | https://doi.org/10.1371/journal.pntd.0004605

Zika Virus Outbreak in Haiti in 2014: Molecular and Clinical Data

John Lednicky, Valery Madsen Beau De Rochars, Maha El Badry, Julia Loeb, Taina Telisma, Sonese Chavannes, Gina Anilis, Eleonora Cella, Massimo Ciccozzi, Mohammed Rashid, Bernard Okech, Marco Salemi, J. Glenn Morris Jr.

PLOS Neglected Tropical Diseases: published April 25, 2016 | https://doi.org/10.1371/journal.pntd.0004687

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor

Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill

PLOS Neglected Tropical Diseases: published April 22, 2016 | https://doi.org/10.1371/journal.pntd.0004601

Use of Molecular Diagnostic Tools for the Identification of Species Responsible for Snakebite in Nepal: A Pilot Study

Sanjib Kumar Sharma, Ulrich Kuch, Patrick Höde, Laura Bruhse, Deb P. Pandey, Anup Ghimire, François Chappuis, Emilie Alirol

PLOS Neglected Tropical Diseases: published April 22, 2016 | https://doi.org/10.1371/journal.pntd.0004620

Reproductive Incompatibility Involving Senegalese Aedes aegypti (L) Is Associated with Chromosome Rearrangements

Laura B. Dickson, Maria V. Sharakhova, Vladimir A. Timoshevskiy, Karen L. Fleming, Alex Caspary, Massamba Sylla, William C. Black IV

PLOS Neglected Tropical Diseases: published April 22, 2016 | https://doi.org/10.1371/journal.pntd.0004626

Inferring the Spatio-temporal Patterns of Dengue Transmission from Surveillance Data in Guangzhou, China

Guanghu Zhu, Jiming Liu, Qi Tan, Benyun Shi

PLOS Neglected Tropical Diseases: published April 22, 2016 | https://doi.org/10.1371/journal.pntd.0004633

Epidemiology of Emergent Madariaga Encephalitis in a Region with Endemic Venezuelan Equine Encephalitis: Initial Host Studies and Human Cross-Sectional Study in Darien, Panama

Amy Y. Vittor, Blas Armien, Publio Gonzalez, Jean-Paul Carrera, Claudia Dominguez, Anayansi Valderrama, Greg E. Glass, Davis Beltran, Julio Cisneros, Eryu Wang, Alex Castillo, Brechla Moreno, Scott C. Weaver

PLOS Neglected Tropical Diseases: published April 21, 2016 | https://doi.org/10.1371/journal.pntd.0004554

Genetic Susceptibility and Predictors of Paradoxical Reactions in Buruli Ulcer

Yves Thierry Barogui, Sandor-Adrian Klis, Roch Christian Johnson, Richard O. Phillips, Eveline van der Veer, Cleo van Diemen, Tjip S. van der Werf, Ymkje Stienstra

PLOS Neglected Tropical Diseases: published April 20, 2016 | https://doi.org/10.1371/journal.pntd.0004594

Mapping the Distribution of Anthrax in Mainland China, 2005–2013

Wan-Jun Chen, Sheng-Jie Lai, Yang Yang, Kun Liu, Xin-Lou Li, Hong-Wu Yao, Yu Li, Hang Zhou, Li-Ping Wang, Di Mu, Wen-Wu Yin, Li-Qun Fang, Hong-Jie Yu, Wu-Chun Cao

PLOS Neglected Tropical Diseases: published April 20, 2016 | https://doi.org/10.1371/journal.pntd.0004637

A Novel Xenomonitoring Technique Using Mosquito Excreta/Feces for the Detection of Filarial Parasites and Malaria

Nils Pilotte, Weam I. Zaky, Brian P. Abrams, Dave D. Chadee, Steven A. Williams

PLOS Neglected Tropical Diseases: published April 20, 2016 | https://doi.org/10.1371/journal.pntd.0004641

Analysis on Gene Expression Profile in Oncospheres and Early Stage Metacestodes from Echinococcus multilocularis

Fuqiang Huang, Zhisheng Dang, Yutaka Suzuki, Terumi Horiuchi, Kinpei Yagi, Hirokazu Kouguchi, Takao Irie, Kyeongsoon Kim, Yuzaburo Oku

PLOS Neglected Tropical Diseases: published April 19, 2016 | https://doi.org/10.1371/journal.pntd.0004634

Characterization of Lethal Zika Virus Infection in AG129 Mice

Matthew T. Aliota, Elizabeth A. Caine, Emma C. Walker, Katrina E. Larkin, Erwin Camacho, Jorge E. Osorio

PLOS Neglected Tropical Diseases: published April 19, 2016 | https://doi.org/10.1371/journal.pntd.0004682

Co-endemicity of Pulmonary Tuberculosis and Intestinal Helminth Infection in the People’s Republic of China

Xin-Xu Li, Zhou-Peng Ren, Li-Xia Wang, Hui Zhang, Shi-Wen Jiang, Jia-Xu Chen, Jin-Feng Wang, Xiao-Nong Zhou

PLOS Neglected Tropical Diseases: published April 18, 2016 | https://doi.org/10.1371/journal.pntd.0004580

Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

Manu De Rycker, John Thomas, Jennifer Riley, Stephen J. Brough, Tim J. Miles, David W. Gray

PLOS Neglected Tropical Diseases: published April 15, 2016 | https://doi.org/10.1371/journal.pntd.0004584

Leprosy on Reunion Island, 2005-2013: Situation and Perspectives

Guillaume Camuset, Sophie Lafarge, Gianandrea Borgherini, Anne Gerber, Nicolas Pouderoux, Aurélie Foucher, Patrice Poubeau, Rodolphe Manaquin, Sophie Larrieu, Pascal Vilain, Laetitita Huiart

PLOS Neglected Tropical Diseases: published April 15, 2016 | https://doi.org/10.1371/journal.pntd.0004612

The Burden of Typhoid and Paratyphoid in India: Systematic Review and Meta-analysis

Jacob John, Carola J. C. Van Aart, Nicholas C. Grassly

PLOS Neglected Tropical Diseases: published April 15, 2016 | https://doi.org/10.1371/journal.pntd.0004616

First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features

Farah T. van Genderen, Ingrid Krishnadath, Rachel Sno, Meritha G. Grunberg, Wilco Zijlmans, Malti R. Adhin

PLOS Neglected Tropical Diseases: published April 15, 2016 | https://doi.org/10.1371/journal.pntd.0004625

Burden and Historical Trend of Buruli Ulcer Prevalence in Selected Communities along the Offin River of Ghana

Kobina Assan Ampah, Prince Asare, Daniel De-Graft Binnah, Samuel Maccaulley, William Opare, Katharina Röltgen, Gerd Pluschke, Dorothy Yeboah-Manu

PLOS Neglected Tropical Diseases: published April 14, 2016 | https://doi.org/10.1371/journal.pntd.0004603

Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India

Kalwaje Eshwara Vandana, Chiranjay Mukhopadhyay, Chaitanya Tellapragada, Asha Kamath, Meghan Tipre, Vinod Bhat, Nalini Sathiakumar

PLOS Neglected Tropical Diseases: published April 14, 2016 | https://doi.org/10.1371/journal.pntd.0004610

Impact of Trichiasis Surgery on Quality of Life: A Longitudinal Study in Ethiopia

Esmael Habtamu, Tariku Wondie, Sintayehu Aweke, Zerihun Tadesse, Mulat Zerihun, Aderajew Mohammed, Zebideru Zewudie, Kelly Callahan, Paul M. Emerson, Robin L. Bailey, David C. W. Mabey, Saul N. Rajak, Hannah Kuper, Sarah Polack, Helen A. Weiss, Matthew J. Burton

PLOS Neglected Tropical Diseases: published April 14, 2016 | https://doi.org/10.1371/journal.pntd.0004627

Differential Diagnosis of Skin Ulcers in a Mycobacterium ulcerans Endemic Area: Data from a Prospective Study in Cameroon

Laurence Toutous Trellu, Patrick Nkemenang, Eric Comte, Geneviève Ehounou, Paul Atangana, Didier Junior Mboua, Barbara Rusch, Earnest Njih Tabah, Jean-François Etard, Yolanda K. Mueller

PLOS Neglected Tropical Diseases: published April 13, 2016 | https://doi.org/10.1371/journal.pntd.0004385

Identification and Genomic Analysis of a Novel Group C Orthobunyavirus Isolated from a Mosquito Captured near Iquitos, Peru

Todd J. Treangen, George Schoeler, Adam M. Phillippy, Nicholas H. Bergman, Michael J. Turell

PLOS Neglected Tropical Diseases: published April 13, 2016 | https://doi.org/10.1371/journal.pntd.0004440

Faecal Parasitology: Concentration Methodology Needs to be Better Standardised

Monika M. Manser, Agatha Christie Santos Saez, Peter L. Chiodini

PLOS Neglected Tropical Diseases: published April 13, 2016 | https://doi.org/10.1371/journal.pntd.0004579

Characteristics of Blood Vessels in Female Genital Schistosomiasis: Paving the Way for Objective Diagnostics at the Point of Care

Sigve Holmen, Hashini Nilushika Galappaththi-Arachchige, Elisabeth Kleppa, Pavitra Pillay, Thajasvarie Naicker, Myra Taylor, Mathias Onsrud, Eyrun Floerecke Kjetland, Fritz Albregtsen

PLOS Neglected Tropical Diseases: published April 13, 2016 | https://doi.org/10.1371/journal.pntd.0004628

Endemicity of Zoonotic Diseases in Pigs and Humans in Lowland and Upland Lao PDR: Identification of Socio-cultural Risk Factors

Hannah R. Holt, Phouth Inthavong, Boualam Khamlome, Kate Blaszak, Chattouphone Keokamphe, Virasack Somoulay, Anousone Phongmany, Peter A. Durr, Kerryne Graham, John Allen, Blánaid Donnelly, Stuart D. Blacksell, Fred Unger, Delia Grace, Silvia Alonso, Jeff Gilbert

PLOS Neglected Tropical Diseases: published April 12, 2016 | https://doi.org/10.1371/journal.pntd.0003913

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

Diego Benítez, Andrea Medeiros, Lucía Fiestas, Esteban A. Panozzo-Zenere, Franziska Maiwald, Kyriakos C. Prousis, Marina Roussaki, Theodora Calogeropoulou, Anastasia Detsi, Timo Jaeger, Jonas Šarlauskas, Lucíja Peterlin Mašič, Conrad Kunick, Guillermo R. Labadie, Leopold Flohé, Marcelo A. Comini

PLOS Neglected Tropical Diseases: published April 12, 2016 | https://doi.org/10.1371/journal.pntd.0004617

Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania

Inge Kroidl, Elmar Saathof, Lucas Maganga, Petra Clowes, Leonard Maboko, Achim Hoerauf, Williams H. Makunde, Antelmo Haule, Prisca Mviombo, Bettina Pitter, Neema Mgeni, Joseph Mabuye, Dickens Kowuor, Upendo Mwingira, Mwelecele N. Malecela, Thomas Löscher, Michael Hoelscher

PLOS Neglected Tropical Diseases: published April 12, 2016 | https://doi.org/10.1371/journal.pntd.0004618

Zika Virus Outbreak in Rio de Janeiro, Brazil: Clinical Characterization, Epidemiological and Virological Aspects

Patrícia Brasil, Guilherme Amaral Calvet, André Machado Siqueira, Mayumi Wakimoto, Patrícia Carvalho de Sequeira, Aline Nobre, Marcel de Souza Borges Quintana, Marco Cesar Lima de Mendonça, Otilia Lupi, Rogerio Valls de Souza, Carolina Romero, Heruza Zogbi, Clarisse da Silveira Bressan, Simone Sampaio Alves, Ricardo Lourenço-de-Oliveira, Rita Maria Ribeiro Nogueira, Marilia Sá Carvalho, Ana Maria Bispo de Filippis, Thomas Jaenisch

PLOS Neglected Tropical Diseases: published April 12, 2016 | https://doi.org/10.1371/journal.pntd.0004636

Geological Changes of the Americas and their Influence on the Diversification of the Neotropical Kissing Bugs (Hemiptera: Reduviidae: Triatominae)

Silvia A. Justi, Cleber Galvão, Carlos G. Schrago

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004527

Cryptosporidium hominis Is a Newly Recognized Pathogen in the Arctic Region of Nunavik, Canada: Molecular Characterization of an Outbreak

Karine Thivierge, Asma Iqbal, Brent Dixon, Réjean Dion, Benoît Levesque, Philippe Cantin, Lyne Cédilotte, Momar Ndao, Jean-François Proulx, Cedric P. Yansouni

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004534

Comparison of the Performance of the TPTest, Tubex, Typhidot and Widal Immunodiagnostic Assays and Blood Cultures in Detecting Patients with Typhoid Fever in Bangladesh, Including Using a Bayesian Latent Class Modeling Approach

Kamrul Islam, Md. Abu Sayeed, Emran Hossen, Farhana Khanam, Richelle C. Charles, Jason Andrews, Edward T. Ryan, Firdausi Qadri

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004558

A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia

Kavi Ratanabanangkoon, Kae Yi Tan, Sukanya Eursakun, Choo Hock Tan, Pavinee Simsiriwong, Teeraporn Pamornsakda, Witthawat Wiriyarat, Chaiya Klinpayom, Nget Hong Tan

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004565

Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection

Yun Shan Goh, Francesca Necchi, Colette M. O’Shaughnessy, Francesca Micoli, Massimiliano Gavini, Stephen P. Young, Chisomo L. Msefula, Esther N. Gondwe, Wilson L. Mandala, Melita A. Gordon, Allan J. Saul, Calman A. MacLennan

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004604

Sensitivity and Specificity of a Prototype Rapid Diagnostic Test for the Detection of Trypanosoma brucei gambiense Infection: A Multi-centric Prospective Study

Sylvie Bisser, Crispin Lumbala, Etienne Nguertoum, Victor Kande, Laurence Flevaud, Gedeao Vatunga, Marleen Boelaert, Philippe Büscher, Theophile Josenando, Paul R. Bessell, Sylvain Biéler, Joseph M. Ndung’u

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004608

Neutrophils Contribute to the Protection Conferred by ArtinM against Intracellular Pathogens: A Study on Leishmania major

Rafael Ricci-Azevedo, Aline Ferreira Oliveira, Marina C. A. V. Conrado, Fernanda Caroline Carvalho, Maria Cristina Roque-Barreira

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004609

Effects of Mother’s Illness and Breastfeeding on Risk of Ebola Virus Disease in a Cohort of Very Young Children

Hilary Bower, Sembia Johnson, Mohamed S. Bangura, Alie Joshua Kamara, Osman Kamara, Saidu H. Mansaray, Daniel Sesay, Cecilia Turay, Francesco Checchi, Judith R. Glynn

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004622

Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections

Guangyan Zhou, Mary M. Stevenson, Timothy G. Geary, Jianguo Xia

PLOS Neglected Tropical Diseases: published April 8, 2016 | https://doi.org/10.1371/journal.pntd.0004624

Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense

Brett A. Eyford, Laura Kaufman, Orly Salama-Alber, Bianca Loveless, Matthew E. Pope, Robert D. Burke, Enock Matovu, Martin J. Boulanger, Terry W. Pearson

PLOS Neglected Tropical Diseases: published April 7, 2016 | https://doi.org/10.1371/journal.pntd.0004510

Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever

Liang Cui, Yie Hou Lee, Tun Linn Thein, Jinling Fang, Junxiong Pang, Eng Eong Ooi, Yee Sin Leo, Choon Nam Ong, Steven R. Tannenbaum

PLOS Neglected Tropical Diseases: published April 7, 2016 | https://doi.org/10.1371/journal.pntd.0004607

The Aetiologies and Impact of Fever in Pregnant Inpatients in Vientiane, Laos

Vilada Chansamouth, Syvilay Thammasack, Rattanaphone Phetsouvanh, Valy Keoluangkot, Catrin E. Moore, Stuart D. Blacksell, Josee Castonguay-Vanier, Audrey Dubot-Pérès, Jarasporn Tangkhabuanbutra, Narongchai Tongyoo, Phooksavanh Souphaphonh, Onanong Sengvilaipaseuth, Manivanh Vongsouvath, Koukeo Phommasone, Davanh Sengdethka, Amphayvanh Seurbsanith, Scott B. Craig, Laura Hermann, Michel Strobel, Paul N. Newton

PLOS Neglected Tropical Diseases: published April 6, 2016 | https://doi.org/10.1371/journal.pntd.0004577

Endomicroscopic and Transcriptomic Analysis of Impaired Barrier Function and Malabsorption in Environmental Enteropathy

Paul Kelly, Ellen Besa, Kanekwa Zyambo, John Louis-Auguste, James Lees, Themba Banda, Rose Soko, Rosemary Banda, Beatrice Amadi, Alastair Watson

PLOS Neglected Tropical Diseases: published April 6, 2016 | https://doi.org/10.1371/journal.pntd.0004600

The Spatio-temporal Distribution of Japanese Encephalitis Cases in Different Age Groups in Mainland China, 2004 – 2014

Xiaolong Li, Shiheng Cui, Xiaoyan Gao, Huanyu Wang, Miao Song, Minghua Li, Shihong Fu, Zhi Lv, Ying He, Wenwen Lei, Bin Wang, Xiaoqing Lu, Guodong Liang

PLOS Neglected Tropical Diseases: published April 6, 2016 | https://doi.org/10.1371/journal.pntd.0004611

A Randomized Controlled Double Blind Trial of Ciclosporin versus Prednisolone in the Management of Leprosy Patients with New Type 1 Reaction, in Ethiopia

Saba M. Lambert, Digafe T. Alembo, Shimelis D. Nigusse, Lawrence K. Yamuah, Stephen L. Walker, Diana N. J. Lockwood

PLOS Neglected Tropical Diseases: published April 5, 2016 | https://doi.org/10.1371/journal.pntd.0004502

Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection

Sridhar Arumugam, Junfei Wei, Zhuyun Liu, David Abraham, Aaron Bell, Maria Elena Bottazzi, Peter J. Hotez, Bin Zhan, Sara Lustigman, Thomas R. Klei

PLOS Neglected Tropical Diseases: published April 5, 2016 | https://doi.org/10.1371/journal.pntd.0004586

The “Buruli Score”: Development of a Multivariable Prediction Model for Diagnosis of Mycobacterium ulcerans Infection in Individuals with Ulcerative Skin Lesions, Akonolinga, Cameroon

Yolanda K. Mueller, Mathieu Bastard, Patrick Nkemenang, Eric Comte, Geneviève Ehounou, Sara Eyangoh, Barbara Rusch, Earnest Njih Tabah, Laurence Toutous Trellu, Jean-Francois Etard

PLOS Neglected Tropical Diseases: published April 5, 2016 | https://doi.org/10.1371/journal.pntd.0004593

Severe Fever with Thrombocytopenia Syndrome Virus Antigen Detection Using Monoclonal Antibodies to the Nucleocapsid Protein

Aiko Fukuma, Shuetsu Fukushi, Tomoki Yoshikawa, Hideki Tani, Satoshi Taniguchi, Takeshi Kurosu, Kazutaka Egawa, Yuto Suda, Harpal Singh, Taro Nomachi, Mutsuyo Gokuden, Katsuyuki Ando, Kouji Kida, Miki Kan, Nobuyuki Kato, Akira Yoshikawa, Hiroaki Kitamoto, Yuko Sato, Tadaki Suzuki, Hideki Hasegawa, Shigeru Morikawa, Masayuki Shimojima, Masayuki Saijo

PLOS Neglected Tropical Diseases: published April 5, 2016 | https://doi.org/10.1371/journal.pntd.0004595

Environmental Mapping of Paracoccidioides spp. in Brazil Reveals New Clues into Genetic Diversity, Biogeography and Wild Host Association

Thales Domingos Arantes, Raquel Cordeiro Theodoro, Marcus de Melo Teixeira, Sandra de Moraes Gimenes Bosco, Eduardo Bagagli

PLOS Neglected Tropical Diseases: published April 5, 2016 | https://doi.org/10.1371/journal.pntd.0004606

Markov Model Predicts Changes in STH Prevalence during Control Activities Even with a Reduced Amount of Baseline Information

Antonio Montresor, Arminder Deol, Natacha à Porta, Nam Lethanh, Dina Jankovic

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004371

Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages

Grazielle R. Goes, Peter S. Rocha, Aline R. S. Diniz, Pedro H. N. Aguiar, Carlos R. Machado, Leda Q. Vieira

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004555

New Trypanosoma evansi Type B Isolates from Ethiopian Dromedary Camels

Hadush Birhanu, Tadesse Gebrehiwot, Bruno Maria Goddeeris, Philippe Büscher, Nick Van Reet

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004556

Ecology of the Tick-Borne Phlebovirus Causing Severe Fever with Thrombocytopenia Syndrome in an Endemic Area of China

Zhifeng Li, Changjun Bao, Jianli Hu, Wendong Liu, Xiaochen Wang, Lei Zhang, Zhengmin Ji, Zhi Feng, Luxun Li, Aihua Shen, Xuejian Liu, Hongjun Zhao, Wenwen Tan, Jiangang Zhou, Xian Qi, Yefei Zhu, Fenyang Tang, Carol J. Cardona, Zheng Xing

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004574

GPS Tracking of Free-Ranging Pigs to Evaluate Ring Strategies for the Control of Cysticercosis/Taeniasis in Peru

Ian W. Pray, Dallas J. Swanson, Viterbo Ayvar, Claudio Muro, Luz M. Moyano, Armando E. Gonzalez, Hector H. Garcia, Seth E. O’Neal, Cysticercosis Working Group in Peru

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004591

Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6

Chaman Saini, Anisuddin Siddiqui, Venkatesh Ramesh, Indira Nath

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004592

Development of a Novel Multiplex Immunoassay Multi-cruzi for the Serological Confirmation of Chagas Disease

Elodie Granjon, Marie-Laure Dichtel-Danjoy, Esber Saba, Ester Sabino, Lea Campos de Oliveira, Maan Zrein

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004596

Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis

Cristina Herrera, Jéssica Kele A. Macêdo, Andrés Feoli, Teresa Escalante, Alexandra Rucavado, José María Gutiérrez, Jay W. Fox

PLOS Neglected Tropical Diseases: published April 1, 2016 | https://doi.org/10.1371/journal.pntd.0004599

Cover

A pig is prepared for tracking with a GPS collar attached to its back.

Editorials

Viewpoints

Related Articles

Historical Profiles and Perspectives

Symposiums

Review

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles