Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum

Sayantanee Biswas, Michelle R. Emond, Grace S. Philip, James D. Jontes

PLOS Genetics: published June 1, 2026 | https://doi.org/10.1371/journal.pgen.1012171

Sequence context and methylation interact to shape germline mutation rate variation at CpG sites

Sheel Chandra, Ziyue Gao

PLOS Genetics: published June 1, 2026 | https://doi.org/10.1371/journal.pgen.1011957

Barrier-to-autointegration factor protects against the cGAS-STING response to chromatin bridges

Laura Chastant, Karine Normandin, Firas El-Mortada, Marc J. Servant, Vincent Archambault

PLOS Genetics: published June 3, 2026 | https://doi.org/10.1371/journal.pgen.1012191

Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation

Buse Cınar Cakmak, Johanna D. Saric, Katrin Wrede, Neil A. Holmes, Julian Haist, Maria A. Schumacher, Mark J. Buttner, Natalia Tschowri

PLOS Genetics: published June 3, 2026 | https://doi.org/10.1371/journal.pgen.1012161

Epistasis among clustered lineage-specific amino acid substitutions in the Drosophila Trio protein

Flora Borne, Andrew M. Taverner, Peter Andolfatto

PLOS Genetics: published June 3, 2026 | https://doi.org/10.1371/journal.pgen.1012175

The stoichiometry of minor-to-major pilins regulates the dynamic activity of the type IVa competence pilus in Vibrio cholerae

Nicholas D. Christman, Triana N. Dalia, Jennifer L. Chlebek, Ankur B. Dalia

PLOS Genetics: published June 4, 2026 | https://doi.org/10.1371/journal.pgen.1012188

Promotion of shade avoidance by BBX5 involves activation of PIF4 along with auxin biosynthetic and signaling genes

Fengyue Zhao, Rongbo Yang, Zhaoqing Song, Yeting Bian, Yuntao Xiao, Dongqing Xu

PLOS Genetics: published June 5, 2026 | https://doi.org/10.1371/journal.pgen.1012177

Chromatin insulators homie and nhomie can interact with distant copies either together or separately, with distinct outcomes for enhancer-promoter interactions

Miki Fujioka, Wenfan Ke, Paul Schedl, James B. Jaynes

PLOS Genetics: published June 5, 2026 | https://doi.org/10.1371/journal.pgen.1011940

Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state

Guoyu Zhu, Miriam A. Genuth, Yanrong Xiao, Abigail A. Kindberg, Kayleigh Hackett, Scott A. Holley

PLOS Genetics: published June 8, 2026 | https://doi.org/10.1371/journal.pgen.1012176

Rv3839-Rv3840 links the endogenous heme biosynthesis pathway with Mycobacterium tuberculosis adaptation to nitric oxide and iron limitation stress

Natalia F. Quirk, Kate N. Gregory, Yasu S. Morita, Shumin Tan

PLOS Genetics: published June 8, 2026 | https://doi.org/10.1371/journal.pgen.1012202

RNA Polymerase III subunit Polr3a is required for craniofacial cartilage and bone development in zebrafish

Bailey T. Lubash, Roxana Gutierrez, Nicole A. Hansen, Kade Fink, Colette A. Hopkins, Lauren B. Sands, Jessica C. Nelson, Kristin E. N. Watt

PLOS Genetics: published June 8, 2026 | https://doi.org/10.1371/journal.pgen.1012164

The importance of nonsense errors: Estimating the rates and implications of ribosome drop-off during protein synthesis

Alexander L. Cope, Denizhan Pak, Michael A. Gilchrist

PLOS Genetics: published June 9, 2026 | https://doi.org/10.1371/journal.pgen.1012162

The regulation of Xrp1 expression by uORFs and main ORF sequences and its function in Drosophila disease models

Hidetaka Katow, Thao Nguyen, Sarah Hyunsoh Park, Hyung Don Ryoo

PLOS Genetics: published June 10, 2026 | https://doi.org/10.1371/journal.pgen.1012203

The neuropeptide neuromedin U receptor NMUR-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival

Deniz Sifoglu, Bianca Pereira, Christina DeGregory, Rahi Shah, Wolfgang Maier, Joanne Guan, Ian Clark, Dhaval Patel, QueeLim Ch’ng, Joy Alcedo

PLOS Genetics: published June 11, 2026 | https://doi.org/10.1371/journal.pgen.1012190

A tti1 mutation in the Tel2-Tti1-Tti2 complex specifically eliminates the cellular function of Rad3^ATR, but not that of other PIKKs in fission yeast

Sankhadip Bhadra, Nafees Ahamad, Saman Khan, Yong-jie Xu

PLOS Genetics: published June 11, 2026 | https://doi.org/10.1371/journal.pgen.1012206

Metabolism fine tuning and cardiokines secretion represent adaptative responses of the heart to High Fat and High Sugar Diets in flies

Lucie Khamvongsa-Charbonnier, Laurent Kremmer, Magali Torres, Sallouha Krifa, Charis Aubert, Alice Corbet, Loic Crespo, Laurence Roder, Laurent Perrin, Nathalie Arquier

PLOS Genetics: published June 11, 2026 | https://doi.org/10.1371/journal.pgen.1012189

CsmR controls both, motility and cell shape, in Haloferax volcanii

Phillip Nußbaum, Felix Grünberger, Felix Neuschütz, Kevin Chou, Shamphavi Sivabalasarma, Alexander Eulitz, Anna-Lena Sailer, Katharina Vogl, Marten Exterkate, Wei He, Anita Marchfelder, Dina Grohmann, Sonja-Verena Albers

PLOS Genetics: published June 12, 2026 | https://doi.org/10.1371/journal.pgen.1012198

Ultra-fast genetic colocalisation across millions of association signals

Mihkel Jesse, Ago-Erik Riet, Kaur Alasoo

PLOS Genetics: published June 17, 2026 | https://doi.org/10.1371/journal.pgen.1012209

Functional profiling of 2,193 ASS1 missense variants: Insights into variant pathogenicity and epistatic interactions in citrullinemia type I

Russell S. Lo, Gareth A. Cromie, Michelle Tang, Amy Sirr, Ljubica Caldovic, Hiroki Morizono, Nicholas Ah Mew, Andrea Gropman, Aimée M. Dudley

PLOS Genetics: published June 17, 2026 | https://doi.org/10.1371/journal.pgen.1012167

Genetic analysis and mapping of adult plant stripe rust resistance loci in CIMMYT wheat ‘Kijil’ under Mexican and Chinese field environments

Shanshan Yan, Lichao Teng, Menghan Xi, Chan Yuan, Liang Wang, Shunda Li, Julio Huerta-Espino, Sridhar Bhavani, Ravi P. Singh, Caixia Lan

PLOS Genetics: published June 18, 2026 | https://doi.org/10.1371/journal.pgen.1012039

Towards a unified model of aneuploid karyotype dynamics

Mathieu Hénault, Lisa M. Wood, Lydia R. Heasley

PLOS Genetics: published June 18, 2026 | https://doi.org/10.1371/journal.pgen.1012210

Genetic risk for high body mass index before and amidst the obesity epidemic: Cross-cohort analysis of four british birth cohort studies

Liam Wright, Neil M. Davies, Gemma Shireby, Dylan M. Williams, Tim T. Morris, David Bann

PLOS Genetics: published June 18, 2026 | https://doi.org/10.1371/journal.pgen.1012138

Lysosome-related organelles employ divergent mechanisms to modulate cytosolic zinc homeostasis

Chaoyi Xie, Yi Luo, Yawen Zheng, Bowen Liu, Shibo Song, Jie Wei, Anbing Shi, Yanling Yan

PLOS Genetics: published June 22, 2026 | https://doi.org/10.1371/journal.pgen.1012199

A point mutation in the FAT domain constitutively increases the kinase activity of Rad3^ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint

Kamal Dev, S. Dean Rider Jr., Balveer Singh, Abhinav Saini, Yong-jie Xu

PLOS Genetics: published June 22, 2026 | https://doi.org/10.1371/journal.pgen.1012213

Correlated protein-RNA associations and a requirement for HNRNPU in the long-range recruitment of Polycomb Repressive Complexes by the lncRNAs Airn and Kcnq1ot1

McKenzie M. Murvin, Shuang Li, Elizabeth W. Abrash, Bridget A. Peck, Samuel P. Boyson, Zhiyue Zhang, Rachel E. Cherney, J. Mauro Calabrese

PLOS Genetics: published June 23, 2026 | https://doi.org/10.1371/journal.pgen.1012215

Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse

İsmail Küçükaylak, Kai Halwas, Francisco Javier Martínez Morcillo, Nils Reiche, Manuel Metzger, Petra Comelli, Birgit Voigt, Jürgen Brinckmann, Sabine Eming, Matthias Hammerschmidt

PLOS Genetics: published June 24, 2026 | https://doi.org/10.1371/journal.pgen.1012200

Cold-responsive interaction between MdRAD23D1 and MdMYB15 confers cold stress tolerance via the CBF pathway in apple (Malus domestica)

Xiaoli Zhang, Benzhou Zhao, Xiaoyan Li, Hui Xia, Fengwang Ma, Dong Liang, Xiaoqing Gong

PLOS Genetics: published June 25, 2026 | https://doi.org/10.1371/journal.pgen.1012207

Nuclear ubiquitin-conjugating enzyme TrUbc4 and F-box protein TrFwd1-mediated modification of Cre1 in Trichoderma reesei establishes a regulatory mechanism for carbon catabolite repression

Gen Xu, Yanli Cao, Yuxiao Xia, Shanshan Jiang, Weixin Zhang, Xiangfeng Meng, Weifeng Liu

PLOS Genetics: published June 26, 2026 | https://doi.org/10.1371/journal.pgen.1012216

Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer’s disease and related dementias in a multi-site autopsy cohort

Brenna Cholerton, Dana Godrich, Jeremy Pasteris, Joe Rivero, Eden R. Martin, Brian W. Kunkle, Adam C. Naj, Kara L. Hamilton-Nelson, Hui Wang, Wan-Ping Lee, Logan Dumitrescu, Timothy J. Hohman, Richard Mayeux, Eric B. Larson, Paul K. Crane, C. Dirk Keene, Caitlin S. Latimer, Shubhabrata Mukherjee, Julia K. Kofler, M. Ilyas Kamboh, David A. Bennett, Laura Molina-Porcel, Michael Cuccaro, Margaret A. Pericak-Vance, Tatjana Rundek, William K. Scott, Walter Kukull, Gerard Schellenberg, Alzheimer’s Disease Genetics Consortium, Gary W. Beecham, Thomas J. Montine

PLOS Genetics: published June 29, 2026 | https://doi.org/10.1371/journal.pgen.1012170

Argonaute proteins orchestrate Meiotic Sex Chromosome Inactivation and timing of the spermatogenic transcriptional program

Maria de las Mercedes Carro, Alexis Dziubek, Amanda Touey-May, Elizabeth A. Popkowski, Mark Abdelmassih, Leah E. Simon, Stephanie L. Tanis, Faraz Ahmed, Jennifer K. Grenier, Andrew Grimson, Paula E. Cohen

PLOS Genetics: published June 29, 2026 | https://doi.org/10.1371/journal.pgen.1012217

Microtubule stiffening by the doublecortin-domain protein ZYG-8 contributes to mitotic spindle orientation during zygote division in Caenorhabditis elegans

Louis Cueff, Loïc Schmitt, Ewen Huet, Sylvain Pastezeur, Méline Coquil, Talia Savary, Anouk Sénard, Jacques Pécréaux, Hélène Bouvrais

PLOS Genetics: published June 29, 2026 | https://doi.org/10.1371/journal.pgen.1012196

Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation

Merve Cakir, Michela Traglia, Stacey Alexeeff, Jennifer L. Ames, Paul Ashwood, Luke P. Grosvenor, Erica P. Gunderson, Danielle H. J. Kim, Jane W. Liang, Yinge Qian, Elizabeth Sahagun, Robert Yolken, Judy Van de Water, Lisa A. Croen, Lauren A. Weiss

PLOS Genetics: published June 30, 2026 | https://doi.org/10.1371/journal.pgen.1012204

Retraction: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence

The PLOS Genetics Editors

PLOS Genetics: published June 16, 2026 | https://doi.org/10.1371/journal.pgen.1012195

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