A modest increase in the level of hepatic c-Myc provided by an Albumin-c-Myc transgene rescues the neonatal growth defect and significantly improves hepatobiliary disease in mice with hepatic ribosomal protein S6 (Rps6) insufficiency (△S6 mice). While the △S6 mouse (second from left) is runted and has a yellow-tinged coat due to a failure of bile duct development and cholestatic-induced hepatocyte death, the mouse expressing a higher level of c-Myc (△S6:c-Myc mouse) (far right) is indistinguishable from the wild-type (WT) mouse (far-left) or its Albumin-c-Myc littermate (third from left) in terms of size and lacks the jaundiced (yellowed) coat of the △S6 mouse. See Comerford et al. Download January's cover page.

Image Credit: R.E. Hammer and S.A. Comerford