PVD neuron of tiam-1 mutants show dramatic loss of dendritic branches and over-extension of the axon (the first panel). Expressing different TIAM-1 fragment, including TIAM-1A (the second panel), TIAM-1B (the third panel), TIAM-1C (the forth panel), and TIAM-1N539 (the bottom panel) in tiam-1 null mutants restore different subcompartments of PVD neuron. These results suggest that axonal growth and dendritic development are respectively controlled by different regions of TIAM-1. See Lin et al.
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Image Credit: Chin-Hsien Lin
Viewpoints
Weldon, Bateson, and the origins of genetics: Reflections on the unraveling and rebuilding of a scientific community
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010379
Review
Formation of benign tumors by stem cell deregulation
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010434
Research Articles
A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans
PLOS Genetics: published October 3, 2022 | https://doi.org/10.1371/journal.pgen.1010314
Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway
PLOS Genetics: published October 3, 2022 | https://doi.org/10.1371/journal.pgen.1010427
The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing
PLOS Genetics: published October 5, 2022 | https://doi.org/10.1371/journal.pgen.1009967
miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis
PLOS Genetics: published October 5, 2022 | https://doi.org/10.1371/journal.pgen.1010418
Phosphorylated histone variant γH2Av is associated with chromatin insulators in Drosophila
PLOS Genetics: published October 5, 2022 | https://doi.org/10.1371/journal.pgen.1010396
Functional analysis of a bitter gustatory receptor highly expressed in the larval maxillary galea of Helicoverpa armigera
PLOS Genetics: published October 7, 2022 | https://doi.org/10.1371/journal.pgen.1010455
Nuclear position modulates long-range chromatin interactions
PLOS Genetics: published October 7, 2022 | https://doi.org/10.1371/journal.pgen.1010451
Antisense non-coding transcription represses the PHO5 model gene at the level of promoter chromatin structure
PLOS Genetics: published October 10, 2022 | https://doi.org/10.1371/journal.pgen.1010432
A two–tiered system for selective receptor and transporter protein degradation
PLOS Genetics: published October 10, 2022 | https://doi.org/10.1371/journal.pgen.1010446
Phosphorylation of MSI-1 is implicated in the regulation of associative memory in Caenorhabditis elegans
PLOS Genetics: published October 12, 2022 | https://doi.org/10.1371/journal.pgen.1010420
Genetic and environmental drivers of large-scale epigenetic variation in Thlaspi arvense
PLOS Genetics: published October 12, 2022 | https://doi.org/10.1371/journal.pgen.1010452
TIAM-1 differentially regulates dendritic and axonal microtubule organization in patterning neuronal development through its multiple domains
PLOS Genetics: published October 12, 2022 | https://doi.org/10.1371/journal.pgen.1010454
The entry of unclosed autophagosomes into vacuoles and its physiological relevance
PLOS Genetics: published October 13, 2022 | https://doi.org/10.1371/journal.pgen.1010431
Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers
PLOS Genetics: published October 13, 2022 | https://doi.org/10.1371/journal.pgen.1010421
Nascent polypeptide-Associated Complex and Signal Recognition Particle have cardiac-specific roles in heart development and remodeling
PLOS Genetics: published October 14, 2022 | https://doi.org/10.1371/journal.pgen.1010448
Cross-species transmission of an ancient endogenous retrovirus and convergent co-option of its envelope gene in two mammalian orders
PLOS Genetics: published October 14, 2022 | https://doi.org/10.1371/journal.pgen.1010458
RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL)
PLOS Genetics: published October 17, 2022 | https://doi.org/10.1371/journal.pgen.1010300
A potential EARLY FLOWERING 3 homolog in Chlamydomonas is involved in the red/violet and blue light signaling pathways for the degradation of RHYTHM OF CHLOROPLAST 15
PLOS Genetics: published October 17, 2022 | https://doi.org/10.1371/journal.pgen.1010449
Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis
PLOS Genetics: published October 17, 2022 | https://doi.org/10.1371/journal.pgen.1010469
Prioritized candidate causal haplotype blocks in plant genome-wide association studies
PLOS Genetics: published October 17, 2022 | https://doi.org/10.1371/journal.pgen.1010437
Transcriptome features of innate immune memory in Drosophila
PLOS Genetics: published October 17, 2022 | https://doi.org/10.1371/journal.pgen.1010005
CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission
PLOS Genetics: published October 24, 2022 | https://doi.org/10.1371/journal.pgen.1010211
Intracellular acidification is a hallmark of thymineless death in E. coli
PLOS Genetics: published October 24, 2022 | https://doi.org/10.1371/journal.pgen.1010456
Cohesin is required for meiotic spindle assembly independent of its role in cohesion in C. elegans
PLOS Genetics: published October 24, 2022 | https://doi.org/10.1371/journal.pgen.1010136
Activation of the integrative and conjugative element Tn916 causes growth arrest and death of host bacteria
PLOS Genetics: published October 24, 2022 | https://doi.org/10.1371/journal.pgen.1010467
Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points
PLOS Genetics: published October 24, 2022 | https://doi.org/10.1371/journal.pgen.1010296
The feedback loop of METTL14 and USP38 regulates cell migration, invasion and EMT as well as metastasis in bladder cancer
PLOS Genetics: published October 26, 2022 | https://doi.org/10.1371/journal.pgen.1010366
Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation
PLOS Genetics: published October 26, 2022 | https://doi.org/10.1371/journal.pgen.1010463
Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010438
A circular RNA Edis-Relish-castor axis regulates neuronal development in Drosophila
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010433
Related Articles
The circular RNA Edis regulates neurodevelopment and innate immunity
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010429
Related Articles
Genome-wide quantification of contributions to sexual fitness identifies genes required for spore viability and health in fission yeast
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010462
Translational buffering by ribosome stalling in upstream open reading frames
PLOS Genetics: published October 31, 2022 | https://doi.org/10.1371/journal.pgen.1010460
A cryptic transcription factor regulates Caulobacter adhesin development
PLOS Genetics: published October 31, 2022 | https://doi.org/10.1371/journal.pgen.1010481
Exon-dependent transcriptional adaptation by exon-junction complex proteins Y14/RNP-4 and MAGOH/MAG-1 in Caenorhabditis elegans
PLOS Genetics: published October 31, 2022 | https://doi.org/10.1371/journal.pgen.1010488
Correction
Correction: Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
PLOS Genetics: published October 31, 2022 | https://doi.org/10.1371/journal.pgen.1010480
Related Articles
Opinion Piece
New rules for genomics-informed COVID-19 responses–Lessons learned from the first waves of the Omicron variant in Australia
PLOS Genetics: published October 13, 2022 | https://doi.org/10.1371/journal.pgen.1010415
Methods
A Prism Vote method for individualized risk prediction of traits in genotype data of Multi-population
PLOS Genetics: published October 27, 2022 | https://doi.org/10.1371/journal.pgen.1010443