June 2022

Confocal image of a P5 mouse ovary section staining with laminin (red), proliferating cell nuclear antigen (green), and DAPI (blue). The medulla, the cortical region, and different types of growing follicles can be observed. As shown by Torres-Cano et al., WT1 is necessary for the activation of both male and female sex-determining pathways. Its deletion during early gonadogenesis produces dramatic defects in adult sex development. See Torres-Cano et al.

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Image Credit: Torres-Cano et al., pgen.1010240

Research Articles

Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice

Seiya Oura, Toshiaki Hino, Takashi Satoh, Taichi Noda, Takayuki Koyano, Ayako Isotani, Makoto Matsuyama, Shizuo Akira, Kei-ichiro Ishiguro, Masahito Ikawa

PLOS Genetics: published June 1, 2022 | https://doi.org/10.1371/journal.pgen.1010241

Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers

Johannes N. Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada

PLOS Genetics: published June 1, 2022 | https://doi.org/10.1371/journal.pgen.1010235

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program

Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E. Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A. Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E. North, the VA Million Veteran Program, Ethan Lange, Leslie A. Lange, Benjamin F. Voight, J. Michael Gaziano, Saiju Pyarajan, Elizabeth R. Hauser, Philip S. Tsao, Peter W. F. Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, Yan V. Sun, Themistocles L. Assimes

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010193

Dynamics of Salmonella enterica and antimicrobial resistance in the Brazilian poultry industry and global impacts on public health

Nabil-Fareed Alikhan, Luisa Zanolli Moreno, Luis Ricardo Castellanos, Marie Anne Chattaway, Jim McLauchlin, Martin Lodge, Justin O’Grady, Roxana Zamudio, Emma Doughty, Liljana Petrovska, Marcos Paulo Vieira Cunha, Terezinha Knöbl, Andrea Micke Moreno, Alison E. Mather

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010174

An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency

Kevin A. Hope, Alexys R. Berman, Randall T. Peterson, Clement Y. Chow

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010228

Using genetic variation to disentangle the complex relationship between food intake and health outcomes

Nicola Pirastu, Ciara McDonnell, Eryk J. Grzeszkowiak, Ninon Mounier, Fumiaki Imamura, Jordi Merino, Felix R. Day, Jie Zheng, Nele Taba, Maria Pina Concas, Linda Repetto, Katherine A. Kentistou, Antonietta Robino, Tõnu Esko, Peter K. Joshi, Krista Fischer, Ken K. Ong, Tom R. Gaunt, Zoltán Kutalik, John R. B. Perry, James F. Wilson

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010162

Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex

Bardya Djahanschiri, Gisela Di Venanzio, Jesus S. Distel, Jennifer Breisch, Marius Alfred Dieckmann, Alexander Goesmann, Beate Averhoff, Stephan Göttig, Gottfried Wilharm, Mario F. Feldman, Ingo Ebersberger

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010020

Generation and characterization of Ccdc28b mutant mice links the Bardet-Biedl associated gene with mild social behavioral phenotypes

Matías Fabregat, Sofía Niño-Rivero, Sabrina Pose, Magdalena Cárdenas-Rodríguez, Mariana Bresque, Karina Hernández, Victoria Prieto-Echagüe, Geraldine Schlapp, Martina Crispo, Patricia Lagos, Natalia Lago, Carlos Escande, Florencia Irigoín, Jose L. Badano

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1009896

Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae

David A. Ellis, George Avraam, Astrid Hoermann, Claudia A. S. Wyer, Yi Xin Ong, George K. Christophides, Nikolai Windbichler

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010244

Single strand gap repair: The presynaptic phase plays a pivotal role in modulating lesion tolerance pathways

Luisa Laureti, Lara Lee, Gaëlle Philippin, Michel Kahi, Vincent Pagès

PLOS Genetics: published June 2, 2022 | https://doi.org/10.1371/journal.pgen.1010238

The Caenorhabditis elegans TDRD5/7-like protein, LOTR-1, interacts with the helicase ZNFX-1 to balance epigenetic signals in the germline

Elisabeth A. Marnik, Miguel V. Almeida, P. Giselle Cipriani, George Chung, Edoardo Caspani, Emil Karaulanov, Hin Hark Gan, John Zinno, Ida J. Isolehto, Fridolin Kielisch, Falk Butter, Catherine S. Sharp, Roisin M. Flanagan, Frederic X. Bonnet, Fabio Piano, René F. Ketting, Kristin C. Gunsalus, Dustin L. Updike

PLOS Genetics: published June 3, 2022 | https://doi.org/10.1371/journal.pgen.1010245

Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer’s disease outside of the APOE region

Javier de la Fuente, Andrew D. Grotzinger, Riccardo E. Marioni, Michel G. Nivard, Elliot M. Tucker-Drob

PLOS Genetics: published June 3, 2022 | https://doi.org/10.1371/journal.pgen.1010208

Regulation of HLA class I expression by non-coding gene variations

Florence Bettens, Halit Ongen, Guillaume Rey, Stéphane Buhler, Zuleika Calderin Sollet, Emmanouil Dermitzakis, Jean Villard

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1010212

A role for the mitotic proteins Bub3 and BuGZ in transcriptional regulation of catalase-3 expression

Yike Zhou, Shuangjie Shen, Chengcheng Du, Ying Wang, Yi Liu, Qun He

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1010254

Empirical estimates of the mutation rate for an alphabaculovirus

Dieke Boezen, Ghulam Ali, Manli Wang, Xi Wang, Wopke van der Werf, Just M. Vlak, Mark P. Zwart

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1009806

Fasciclin 2 engages EGFR in an auto-stimulatory loop to promote imaginal disc cell proliferation in Drosophila

Emma Velasquez, Jose A. Gomez-Sanchez, Emmanuelle Donier, Carmen Grijota-Martinez, Hugo Cabedo, Luis Garcia-Alonso

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1010224

Widespread phages of endosymbionts: Phage WO genomics and the proposed taxonomic classification of Symbioviridae

Sarah R. Bordenstein, Seth R. Bordenstein

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1010227

Tissue-specific inhibition of protein sumoylation uncovers diverse SUMO functions during C. elegans vulval development

Aleksandra Fergin, Gabriel Boesch, Nadja R. Greter, Simon Berger, Alex Hajnal

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1009978

The phospho-docking protein 14-3-3 regulates microtubule-associated proteins in oocytes including the chromosomal passenger Borealin

Charlotte Repton, C. Fiona Cullen, Mariana F. A. Costa, Christos Spanos, Juri Rappsilber, Hiroyuki Ohkura

PLOS Genetics: published June 6, 2022 | https://doi.org/10.1371/journal.pgen.1009995

Network assisted analysis of de novo variants using protein-protein interaction information identified 46 candidate genes for congenital heart disease

Yuhan Xie, Wei Jiang, Weilai Dong, Hongyu Li, Sheng Chih Jin, Martina Brueckner, Hongyu Zhao

PLOS Genetics: published June 7, 2022 | https://doi.org/10.1371/journal.pgen.1010252

OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans

Ichiro Aoki, Paola Jurado, Kanji Nawa, Rumi Kondo, Riku Yamashiro, Hironori J. Matsuyama, Isidre Ferrer, Shunji Nakano, Ikue Mori

PLOS Genetics: published June 8, 2022 | https://doi.org/10.1371/journal.pgen.1010219

Identification of Arhgef12 and Prkci as genetic modifiers of retinal dysplasia in the Crb1^rd8 mouse model

Sonia M. Weatherly, Gayle B. Collin, Jeremy R. Charette, Lisa Stone, Nattaya Damkham, Lillian F. Hyde, James G. Peterson, Wanda Hicks, Gregory W. Carter, Jürgen K. Naggert, Mark P. Krebs, Patsy M. Nishina

PLOS Genetics: published June 8, 2022 | https://doi.org/10.1371/journal.pgen.1009798

Single cell transcriptomics reveals dysregulated cellular and molecular networks in a fragile X syndrome model

Elisa Donnard, Huan Shu, Manuel Garber

PLOS Genetics: published June 8, 2022 | https://doi.org/10.1371/journal.pgen.1010221

Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Ruixue Zhao, Zhiwen Zhu, Ruxu Geng, Xuguang Jiang, Wei Li, Guangshuo Ou

PLOS Genetics: published June 9, 2022 | https://doi.org/10.1371/journal.pgen.1010223

Sex-specific variation in R-loop formation in Drosophila melanogaster

Timothy J. Stanek, Weihuan Cao, Rohan M Mehra, Christopher E. Ellison

PLOS Genetics: published June 10, 2022 | https://doi.org/10.1371/journal.pgen.1010268

Krüppel-like factor 15 integrated autophagy and gluconeogenesis to maintain glucose homeostasis under 20-hydroxyecdysone regulation

Xiao-Pei Wang, Zhen Huang, Yan-Li Li, Ke-Yan Jin, Du-Juan Dong, Jin-Xing Wang, Xiao-Fan Zhao

PLOS Genetics: published June 13, 2022 | https://doi.org/10.1371/journal.pgen.1010229

Site-specific MCM sumoylation prevents genome rearrangements by controlling origin-bound MCM

Yun Quan, Qian-yi Zhang, Ann L. Zhou, Yuhao Wang, Jiaxi Cai, Yong-qi Gao, Huilin Zhou

PLOS Genetics: published June 13, 2022 | https://doi.org/10.1371/journal.pgen.1010275

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice

Alejo Torres-Cano, Rosa Portella-Fortuny, Claudia Müller-Sánchez, Sonia Porras-Marfil, Marina Ramiro-Pareta, You-Ying Chau, Manuel Reina, Francesc X. Soriano, Ofelia M. Martínez-Estrada

PLOS Genetics: published June 15, 2022 | https://doi.org/10.1371/journal.pgen.1010240

High sorbic acid resistance of Penicillium roqueforti is mediated by the SORBUS gene cluster

Maarten Punt, Sjoerd J. Seekles, Jisca L. van Dam, Connor de Adelhart Toorop, Raithel R. Martina, Jos Houbraken, Arthur F. J. Ram, Han A. B. Wösten, Robin A. Ohm

PLOS Genetics: published June 15, 2022 | https://doi.org/10.1371/journal.pgen.1010086

Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells

Samantha M. Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, Marco Trizzino

PLOS Genetics: published June 15, 2022 | https://doi.org/10.1371/journal.pgen.1010225

The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution

Katharina B. Böndel, Toby Samuels, Rory J. Craig, Rob W. Ness, Nick Colegrave, Peter D. Keightley

PLOS Genetics: published June 15, 2022 | https://doi.org/10.1371/journal.pgen.1009840

Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats

Heidi Anderson, Stephen Davison, Katherine M. Lytle, Leena Honkanen, Jamie Freyer, Julia Mathlin, Kaisa Kyöstilä, Laura Inman, Annette Louviere, Rebecca Chodroff Foran, Oliver P. Forman, Hannes Lohi, Jonas Donner

PLOS Genetics: published June 16, 2022 | https://doi.org/10.1371/journal.pgen.1009804

Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

Ioanna Pavlaki, Michael Shapiro, Giuseppina Pisignano, Stephanie M. E. Jones, Jelena Telenius, Silvia Muñoz-Descalzo, Robert J. Williams, Jim R. Hughes, Keith W. Vance

PLOS Genetics: published June 16, 2022 | https://doi.org/10.1371/journal.pgen.1010230

Combined analyses of RNA-sequence and Hi-C along with GWAS loci—A novel approach to dissect keloid disorder genetic mechanism

Jia Huang, Xiaobo Zhou, Wenbo Wang, Guangdong Zhou, WenJie Zhang, Zhen Gao, Xiaoli Wu, Wei Liu

PLOS Genetics: published June 16, 2022 | https://doi.org/10.1371/journal.pgen.1010168

EPIC: Inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing

Rujin Wang, Dan-Yu Lin, Yuchao Jiang

PLOS Genetics: published June 16, 2022 | https://doi.org/10.1371/journal.pgen.1010251

Repeated truncation of a modular antimicrobial peptide gene for neural context

Mark A. Hanson, Bruno Lemaitre

PLOS Genetics: published June 17, 2022 | https://doi.org/10.1371/journal.pgen.1010259

Intragenomic variation in non-adaptive nucleotide biases causes underestimation of selection on synonymous codon usage

Alexander L. Cope, Premal Shah

PLOS Genetics: published June 17, 2022 | https://doi.org/10.1371/journal.pgen.1010256

The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1

Lijiang Ma, Nicole S. Bryce, Adam W. Turner, Antonio F. Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina d’Escamard, Nirupama Chandel, Bhargavi V’Gangula, Kathryn Wolhuter, Daniella Kadian-Dodov, Oscar Franzen, Arno Ruusalepp, Ke Hao, Clint L. Miller, Johan L. M. Björkegren, Jason C. Kovacic

PLOS Genetics: published June 17, 2022 | https://doi.org/10.1371/journal.pgen.1010261

Translin facilitates RNA polymerase II dissociation and suppresses genome instability during RNase H2- and Dicer-deficiency

Natalia Gomez-Escobar, Ahad A. A. Alsaiari, Hanadi A. S. Alahamadi, Othman Alzahrani, Ellen Vernon, Hussam A. E. Althagafi, Nasser S. Almobadel, David W. Pryce, Jane A. Wakeman, Ramsay J. McFarlane

PLOS Genetics: published June 17, 2022 | https://doi.org/10.1371/journal.pgen.1010267

A mouse model for Li-Fraumeni-Like Syndrome with cardiac angiosarcomas associated to POT1 mutations

Paula Martínez, Raúl Sánchez-Vázquez, Iole Ferrara-Romeo, Rosa Serrano, Juana M. Flores, Maria A. Blasco

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010260

Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes

Yuan Zhang, Shasha Zhang, Han Zhou, Xiangyu Ma, Leilei Wu, Mengyao Tian, Siyu Li, Xiaoyun Qian, Xia Gao, Renjie Chai

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010232

P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens

Ana Duarte, Adam Pym, William T. Garrood, Bartlomiej J. Troczka, Christoph T. Zimmer, T. G. Emyr Davies, Ralf Nauen, Andrias O. O’Reilly, Chris Bass

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010279

Comprehensive analysis of cis- and trans-acting factors affecting ectopic Break-Induced Replication

Tannia Uribe-Calvillo, Laetitia Maestroni, Marie-Claude Marsolier, Basheer Khadaroo, Christine Arbiol, Jonathan Schott, Bertrand Llorente

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010124

Control of nitrogen fixation and ammonia excretion in Azorhizobium caulinodans

Timothy Lyndon Haskett, Ramakrishnan Karunakaran, Marcelo Bueno Batista, Ray Dixon, Philip Simon Poole

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010276

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence

Vanesa C. Sanchez, Howard H. Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L. Carofino, Justin Lack, Jennifer E. Dwyer, R. Mark Simpson, Christophe Cataisson, Max P. Lee, Ji Luo, Kent W. Hunter, Stuart H. Yuspa

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010271

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

Senthil-Kumar Devan, Stephan Schott-Verdugo, Kira Müntjes, Lilli Bismar, Jens Reiners, Eymen Hachani, Lutz Schmitt, Astrid Höppner, Sander HJ Smits, Holger Gohlke, Michael Feldbrügge

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010269

Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2

Tinna Reynisdottir, Kimberley Jade Anderson, Leandros Boukas, Hans Tomas Bjornsson

PLOS Genetics: published June 21, 2022 | https://doi.org/10.1371/journal.pgen.1010278

Old genes in new places: A taxon-rich analysis of interdomain lateral gene transfer events

Auden Cote-L’Heureux, Xyrus X. Maurer-Alcalá, Laura A. Katz

PLOS Genetics: published June 22, 2022 | https://doi.org/10.1371/journal.pgen.1010239

Distinct developmental and degenerative functions of SARM1 require NAD⁺ hydrolase activity

E. J. Brace, Kow Essuman, Xianrong Mao, John Palucki, Yo Sasaki, Jeff Milbrandt, Aaron DiAntonio

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010246

Divergent signaling requirements of dSARM in injury-induced degeneration and developmental glial phagocytosis

Kelsey A. Herrmann, Yizhou Liu, Arnau Llobet-Rosell, Colleen N. McLaughlin, Lukas J. Neukomm, Jaeda C. Coutinho-Budd, Heather T. Broihier

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010257

Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth

Joachim Berger, Silke Berger, Peter D. Currie

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010287

The AalNix3&4 isoform is required and sufficient to convert Aedes albopictus females into males

Yijie Zhao, Binbin Jin, Peiwen Liu, Xiaolin Xiao, Lijun Cai, Zhensheng Xie, Ling Kong, Tong Liu, Wenqiang Yang, Yang Wu, Jinbao Gu, Zhijian Tu, Anthony A. James, Xiao-Guang Chen

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010280

Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery

David M. Gordon, David Cunningham, Gloria Zender, Patrick J. Lawrence, Jacqueline S. Penaloza, Hui Lin, Sara M. Fitzgerald-Butt, Katherine Myers, Tiffany Duong, Donald J. Corsmeier, Jeffrey B. Gaither, Harkness C. Kuck, Saranga Wijeratne, Blythe Moreland, Benjamin J. Kelly, Baylor-Johns Hopkins Center for Mendelian Genomics, Vidu Garg, Peter White, Kim L. McBride

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010236

Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals

Rémi Tournebize, Gillian Chu, Priya Moorjani

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010243

Selective role of the DNA helicase Mcm5 in BMP retrograde signaling during Drosophila neuronal differentiation

Irene Rubio-Ferrera, Pablo Baladrón-de-Juan, Luis Clarembaux-Badell, Marta Truchado-Garcia, Sheila Jordán-Álvarez, Stefan Thor, Jonathan Benito-Sipos, Ignacio Monedero Cobeta

PLOS Genetics: published June 23, 2022 | https://doi.org/10.1371/journal.pgen.1010255

Juvenile hormone promotes paracellular transport of yolk proteins via remodeling zonula adherens at tricellular junctions in the follicular epithelium

Hongyuan Zheng, Ningbo Wang, Jiaqi Yun, Huijing Xu, Jiebing Yang, Shutang Zhou

PLOS Genetics: published June 27, 2022 | https://doi.org/10.1371/journal.pgen.1010292

A bistable prokaryotic differentiation system underlying development of conjugative transfer competence

Sandra Sulser, Andrea Vucicevic, Veronica Bellini, Roxane Moritz, François Delavat, Vladimir Sentchilo, Nicolas Carraro, Jan Roelof van der Meer

PLOS Genetics: published June 28, 2022 | https://doi.org/10.1371/journal.pgen.1010286

Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice

Lena Arévalo, Gina Esther Merges, Simon Schneider, Franka Enow Oben, Isabelle Sophie Neumann, Hubert Schorle

PLOS Genetics: published June 28, 2022 | https://doi.org/10.1371/journal.pgen.1010272

Two duplicated gsdf homeologs cooperatively regulate male differentiation by inhibiting cyp19a1a transcription in a hexaploid fish

Ming-Tao Wang, Zhi Li, Miao Ding, Tian-Zi Yao, Sheng Yang, Xiao-Juan Zhang, Chun Miao, Wen-Xuan Du, Qian Shi, Shun Li, Jie Mei, Yang Wang, Zhong-Wei Wang, Li Zhou, Xi-Yin Li, Jian-Fang Gui

PLOS Genetics: published June 29, 2022 | https://doi.org/10.1371/journal.pgen.1010288

The essential Rhodobacter sphaeroides CenKR two-component system regulates cell division and envelope biosynthesis

Bryan D. Lakey, Kevin S. Myers, François Alberge, Erin L. Mettert, Patricia J. Kiley, Daniel R. Noguera, Timothy J. Donohue

PLOS Genetics: published June 29, 2022 | https://doi.org/10.1371/journal.pgen.1010270

PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy

Yukako Oe, Keita Kakuda, Shin-ichiro Yoshimura, Naohiro Hara, Junya Hasegawa, Seigo Terawaki, Yasuyoshi Kimura, Kensuke Ikenaka, Shiro Suetsugu, Hideki Mochizuki, Tamotsu Yoshimori, Shuhei Nakamura

PLOS Genetics: published June 30, 2022 | https://doi.org/10.1371/journal.pgen.1010264

Integration of multidimensional splicing data and GWAS summary statistics for risk gene discovery

Ying Ji, Qiang Wei, Rui Chen, Quan Wang, Ran Tao, Bingshan Li

PLOS Genetics: published June 30, 2022 | https://doi.org/10.1371/journal.pgen.1009814

Corrections

Correction: Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components

Devyn Oliver, Shankar Ramachandran, Alison Philbrook, Christopher M. Lambert, Ken C. Q. Nguyen, David H. Hall, Michael M. Francis

PLOS Genetics: published June 24, 2022 | https://doi.org/10.1371/journal.pgen.1010291

Correction: MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity

Meenalakshmi Chinnam, Chao Xu, Rati Lama, Xiaojing Zhang, Carlos D. Cedeno, Yanqing Wang, Aimee B. Stablewski, David W. Goodrich, Xinjiang Wang

PLOS Genetics: published June 27, 2022 | https://doi.org/10.1371/journal.pgen.1010293

Cover

Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.

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