Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

Aziz Aiderus, Justin Y. Newberg, Liliana Guzman-Rojas, Ana M. Contreras-Sandoval, Amanda L. Meshey, Devin J. Jones, Felipe Amaya-Manzanares, Roberto Rangel, Jerrold M. Ward, Song-Choon Lee, Kenneth Hon-Kim Ban, Keith Rogers, Susan M. Rogers, Luxmanan Selvanesan, Leslie A. McNoe, Neal G. Copeland, Nancy A. Jenkins, Kenneth Y. Tsai, Michael A. Black, Karen M. Mann, Michael B. Mann

PLOS Genetics: published August 16, 2021 | https://doi.org/10.1371/journal.pgen.1009094

A conserved role of the duplicated Masculinizer gene in sex determination of the Mediterranean flour moth, Ephestia kuehniella

Sander Visser, Anna Voleníková, Petr Nguyen, Eveline C. Verhulst, František Marec

PLOS Genetics: published August 2, 2021 | https://doi.org/10.1371/journal.pgen.1009420

Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters

Moustafa M. Saleh, Célia Jeronimo, François Robert, Gabriel E. Zentner

PLOS Genetics: published August 12, 2021 | https://doi.org/10.1371/journal.pgen.1009529

Genomic islands targeting dusA in Vibrio species are distantly related to Salmonella Genomic Island 1 and mobilizable by IncC conjugative plasmids

Romain Durand, Florence Deschênes, Vincent Burrus

PLOS Genetics: published August 20, 2021 | https://doi.org/10.1371/journal.pgen.1009669

An auxin signaling network translates low-sugar-state input into compensated cell enlargement in the fugu5 cotyledon

Hiromitsu Tabeta, Shunsuke Watanabe, Keita Fukuda, Shizuka Gunji, Mariko Asaoka, Masami Yokota Hirai, Mitsunori Seo, Hirokazu Tsukaya, Ali Ferjani

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009674

Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis

Aresh Sahu, Susnata Karmakar, Sudipta Halder, Gaurab Ghosh, Sayan Acharjee, Purbasa Dasgupta, Ritabrata Ghosh, Girish Deshpande, Mohit Prasad

PLOS Genetics: published August 3, 2021 | https://doi.org/10.1371/journal.pgen.1009685

A ubiquitin-like protein encoded by the “noncoding” RNA TINCR promotes keratinocyte proliferation and wound healing

Akihiro Nita, Akinobu Matsumoto, Ronghao Tang, Chisa Shiraishi, Kazuya Ichihara, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Gaku Tsuji, Masutaka Furue, Bumpei Katayama, Toshiyuki Ozawa, Teruasa Murata, Teruki Dainichi, Kenji Kabashima, Atsushi Hatano, Masaki Matsumoto, Keiichi I. Nakayama

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009686

Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function

Tadashi Yamamuro, Shuhei Nakamura, Yu Yamano, Tsutomu Endo, Kyosuke Yanagawa, Ayaka Tokumura, Takafumi Matsumura, Kiyonori Kobayashi, Hideto Mori, Yusuke Enokidani, Gota Yoshida, Hitomi Imoto, Tsuyoshi Kawabata, Maho Hamasaki, Akiko Kuma, Sohei Kuribayashi, Kentaro Takezawa, Yuki Okada, Manabu Ozawa, Shinichiro Fukuhara, Takashi Shinohara, Masahito Ikawa, Tamotsu Yoshimori

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009688

The native cistrome and sequence motif families of the maize ear

Savannah D. Savadel, Thomas Hartwig, Zachary M. Turpin, Daniel L. Vera, Pei-Yau Lung, Xin Sui, Max Blank, Wolf B. Frommer, Jonathan H. Dennis, Jinfeng Zhang, Hank W. Bass

PLOS Genetics: published August 12, 2021 | https://doi.org/10.1371/journal.pgen.1009689

Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish

Shuo Gao, Zixuan Wang, Luxiang Wang, Haihong Wang, Hao Yuan, Xiaohui Liu, Saijuan Chen, Zhu Chen, Hugues de Thé, Wenqing Zhang, Yiyue Zhang, Jun Zhu, Jun Zhou

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009693

Genome scans of facial features in East Africans and cross-population comparisons reveal novel associations

Chenxing Liu, Myoung Keun Lee, Sahin Naqvi, Hanne Hoskens, Dongjing Liu, Julie D. White, Karlijne Indencleef, Harold Matthews, Ryan J. Eller, Jiarui Li, Jaaved Mohammed, Tomek Swigut, Stephen Richmond, Mange Manyama, Benedikt Hallgrímsson, Richard A. Spritz, Eleanor Feingold, Mary L. Marazita, Joanna Wysocka, Susan Walsh, Mark D. Shriver, Peter Claes, Seth M. Weinberg, John R. Shaffer

PLOS Genetics: published August 19, 2021 | https://doi.org/10.1371/journal.pgen.1009695

Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development

Laura E. Kuil, Katherine C. MacKenzie, Clara S. Tang, Jonathan D. Windster, Thuy Linh Le, Anwarul Karim, Bianca M. de Graaf, Robert van der Helm, Yolande van Bever, Cornelius E. J. Sloots, Conny Meeussen, Dick Tibboel, Annelies de Klein, René M. H. Wijnen, Jeanne Amiel, Stanislas Lyonnet, Maria-Mercè Garcia-Barcelo, Paul K. H. Tam, Maria M. Alves, Alice S. Brooks, Robert M. W. Hofstra, Erwin Brosens

PLOS Genetics: published August 6, 2021 | https://doi.org/10.1371/journal.pgen.1009698

OsMADS23 phosphorylated by SAPK9 confers drought and salt tolerance by regulating ABA biosynthesis in rice

Xingxing Li, Bo Yu, Qi Wu, Qian Min, Rongfeng Zeng, Zizhao Xie, Junli Huang

PLOS Genetics: published August 3, 2021 | https://doi.org/10.1371/journal.pgen.1009699

Phylogenomic assessment of the role of hybridization and introgression in trait evolution

Yaxuan Wang, Zhen Cao, Huw A. Ogilvie, Luay Nakhleh

PLOS Genetics: published August 18, 2021 | https://doi.org/10.1371/journal.pgen.1009701

How did the guppy Y chromosome evolve?

Deborah Charlesworth, Roberta Bergero, Chay Graham, Jim Gardner, Karen Keegan

PLOS Genetics: published August 9, 2021 | https://doi.org/10.1371/journal.pgen.1009704

A Y-linked anti-Müllerian hormone type-II receptor is the sex-determining gene in ayu, Plecoglossus altivelis

Masatoshi Nakamoto, Tsubasa Uchino, Eriko Koshimizu, Yudai Kuchiishi, Ryota Sekiguchi, Liu Wang, Ryusuke Sudo, Masato Endo, Yann Guiguen, Manfred Schartl, John H. Postlethwait, Takashi Sakamoto

PLOS Genetics: published August 26, 2021 | https://doi.org/10.1371/journal.pgen.1009705

Ubx-Collier signaling cascade maintains blood progenitors in the posterior lobes of the Drosophila larval lymph gland

Aditya Kanwal, Pranav Vijay Joshi, Sudip Mandal, Lolitika Mandal

PLOS Genetics: published August 9, 2021 | https://doi.org/10.1371/journal.pgen.1009709

DNA methyltransferase CHROMOMETHYLASE3 prevents ONSEN transposon silencing under heat stress

Kosuke Nozawa, Jiani Chen, Jianjun Jiang, Sarah M. Leichter, Masataka Yamada, Takamasa Suzuki, Fengquan Liu, Hidetaka Ito, Xuehua Zhong

PLOS Genetics: published August 19, 2021 | https://doi.org/10.1371/journal.pgen.1009710

Multitrait GWAS to connect disease variants and biological mechanisms

Hanna Julienne, Vincent Laville, Zachary R. McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Cyril Nerin, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie-Pierre Dube, Peter Kraft, Iuliana Ionita-Laza, Bjarni J. Vilhjálmsson, Hugues Aschard

PLOS Genetics: published August 30, 2021 | https://doi.org/10.1371/journal.pgen.1009713

Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs

Matthias Christen, Sandra Högler, Miriam Kleiter, Michael Leschnik, Corinna Weber, Denise Thaller, Vidhya Jagannathan, Tosso Leeb

PLOS Genetics: published August 2, 2021 | https://doi.org/10.1371/journal.pgen.1009716

Distribution of Holliday junctions and repair forks during Escherichia coli DNA double-strand break repair

Tahirah Yasmin, Benura Azeroglu, Charlotte A. Cockram, David R. F. Leach

PLOS Genetics: published August 25, 2021 | https://doi.org/10.1371/journal.pgen.1009717

Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation

Ruijuan Tang, Wuren Huang, Jingmin Guan, Qiuning Liu, Brenda T. Beerntsen, Erjun Ling

PLOS Genetics: published August 9, 2021 | https://doi.org/10.1371/journal.pgen.1009718

Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens

Jennifer T. Pentz, Peter A. Lind

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009722

The impact of age on genetic risk for common diseases

Xilin Jiang, Chris Holmes, Gil McVean

PLOS Genetics: published August 26, 2021 | https://doi.org/10.1371/journal.pgen.1009723

Cholecystokinin-like peptide mediates satiety by inhibiting sugar attraction

Di Guo, Yi-Jie Zhang, Su Zhang, Jian Li, Chao Guo, Yu-Feng Pan, Ning Zhang, Chen-Xi Liu, Ya-Long Jia, Chen-Yu Li, Jun-Yu Ma, Dick R. Nässel, Cong-Fen Gao, Shun-Fan Wu

PLOS Genetics: published August 16, 2021 | https://doi.org/10.1371/journal.pgen.1009724

Suppression of Vps13 adaptor protein mutants reveals a central role for PI4P in regulating prospore membrane extension

Tsuyoshi S. Nakamura, Yasuyuki Suda, Kenji Muneshige, Yuji Fujieda, Yuuya Okumura, Ichiro Inoue, Takayuki Tanaka, Tetsuo Takahashi, Hideki Nakanishi, Xiao-Dong Gao, Yasushi Okada, Aaron M. Neiman, Hiroyuki Tachikawa

PLOS Genetics: published August 18, 2021 | https://doi.org/10.1371/journal.pgen.1009727

Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis

Evan Witt, Zhantao Shao, Chun Hu, Henry M. Krause, Li Zhao

PLOS Genetics: published August 17, 2021 | https://doi.org/10.1371/journal.pgen.1009728

Feedback regulation of Notch signaling and myogenesis connected by MyoD–Dll1 axis

Haifeng Zhang, Renjie Shang, Pengpeng Bi

PLOS Genetics: published August 9, 2021 | https://doi.org/10.1371/journal.pgen.1009729

A genetic screen in Drosophila uncovers the multifaceted properties of the NUP98-HOXA9 oncogene

Gwenaëlle Gavory, Caroline Baril, Gino Laberge, Gawa Bidla, Surapong Koonpaew, Thomas Sonea, Guy Sauvageau, Marc Therrien

PLOS Genetics: published August 12, 2021 | https://doi.org/10.1371/journal.pgen.1009730

Mitochondrial fission, integrity and completion of mitophagy require separable functions of Vps13D in Drosophila neurons

Ryan Insolera, Péter Lőrincz, Alec J. Wishnie, Gábor Juhász, Catherine A. Collins

PLOS Genetics: published August 12, 2021 | https://doi.org/10.1371/journal.pgen.1009731

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

Farida S. Akhtari, Adrian J. Green, George W. Small, Tammy M. Havener, John S. House, Kyle R. Roell, David M. Reif, Howard L. McLeod, Timothy Wiltshire, Alison A. Motsinger-Reif

PLOS Genetics: published August 26, 2021 | https://doi.org/10.1371/journal.pgen.1009732

Recovery from heat shock requires the microRNA pathway in Caenorhabditis elegans

Delaney C. Pagliuso, Devavrat M. Bodas, Amy E. Pasquinelli

PLOS Genetics: published August 5, 2021 | https://doi.org/10.1371/journal.pgen.1009734

Chromoanagenesis from radiation-induced genome damage in Populus

Weier Guo, Luca Comai, Isabelle M. Henry

PLOS Genetics: published August 25, 2021 | https://doi.org/10.1371/journal.pgen.1009735

Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver

Benjamin P. Flynn, Matthew T. Birnie, Yvonne M. Kershaw, Audrys G. Pauza, Sohyoung Kim, Songjoon Baek, Mark F. Rogers, Alex R. Paterson, Diana A. Stavreva, David Murphy, Gordon L. Hager, Stafford L. Lightman, Becky L. Conway-Campbell

PLOS Genetics: published August 10, 2021 | https://doi.org/10.1371/journal.pgen.1009737

EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis

Jennifer Soler Beatty, Cristina Molnar, Carlos M. Luque, Jose F. de Celis, María D. Martín-Bermudo

PLOS Genetics: published August 19, 2021 | https://doi.org/10.1371/journal.pgen.1009738

Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii

Klaas Schotanus, Vikas Yadav, Joseph Heitman

PLOS Genetics: published August 31, 2021 | https://doi.org/10.1371/journal.pgen.1009743

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila

Andrea Lukacs, Andreas W. Thomae, Peter Krueger, Tamas Schauer, Anuroop V. Venkatasubramani, Natalia Y. Kochanova, Wasim Aftab, Rupam Choudhury, Ignasi Forne, Axel Imhof

PLOS Genetics: published August 23, 2021 | https://doi.org/10.1371/journal.pgen.1009744

The Easter Egg Weevil (Pachyrhynchus) genome reveals syntenic patterns in Coleoptera across 200 million years of evolution

Matthew H. Van Dam, Analyn Anzano Cabras, James B. Henderson, Andrew J. Rominger, Cynthia Pérez Estrada, Arina D. Omer, Olga Dudchenko, Erez Lieberman Aiden, Athena W. Lam

PLOS Genetics: published August 30, 2021 | https://doi.org/10.1371/journal.pgen.1009745

Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages

Swadhin Chandra Jana, Priya Dutta, Akanksha Jain, Anjusha Singh, Lavanya Adusumilli, Mukul Girotra, Diksha Kumari, Seema Shirolikar, Krishanu Ray

PLOS Genetics: published August 19, 2021 | https://doi.org/10.1371/journal.pgen.1009752

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1. Correction: Kinesin-2 transports Orco into the olfactory cilium of Drosophila melanogaster at specific developmental stages

Nuclear translocation of MTL5 from cytoplasm requires its direct interaction with LIN9 and is essential for male meiosis and fertility

Xingxia Zhang, Ming Li, Xiaohua Jiang, Hui Ma, Suixing Fan, Yang Li, Changping Yu, Jianze Xu, Ranjha Khan, Hanwei Jiang, Qinghua Shi

PLOS Genetics: published August 13, 2021 | https://doi.org/10.1371/journal.pgen.1009753

Multi-scale inference of genetic trait architecture using biologically annotated neural networks

Pinar Demetci, Wei Cheng, Gregory Darnell, Xiang Zhou, Sohini Ramachandran, Lorin Crawford

PLOS Genetics: published August 19, 2021 | https://doi.org/10.1371/journal.pgen.1009754

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody

Chiara Merigliano, Romina Burla, Mattia La Torre, Simona Del Giudice, Hsiangling Teo, Chong Wai Liew, Alexandre Chojnowski, Wah Ing Goh, Yolanda Olmos, Klizia Maccaroni, Maria Giubettini, Irene Chiolo, Jeremy G. Carlton, Domenico Raimondo, Fiammetta Vernì, Colin L. Stewart, Daniela Rhodes, Graham D. Wright, Brian E. Burke, Isabella Saggio

PLOS Genetics: published August 27, 2021 | https://doi.org/10.1371/journal.pgen.1009757

Average semivariance yields accurate estimates of the fraction of marker-associated genetic variance and heritability in complex trait analyses

Mitchell J. Feldmann, Hans-Peter Piepho, William C. Bridges, Steven J. Knapp

PLOS Genetics: published August 26, 2021 | https://doi.org/10.1371/journal.pgen.1009762

Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting

Charlene Watterston, Rami Halabi, Sarah McFarlane, Sarah J. Childs

PLOS Genetics: published August 23, 2021 | https://doi.org/10.1371/journal.pgen.1009769

The genetics and evolution of eye color in domestic pigeons (Columba livia)

Si Si, Xiao Xu, Yan Zhuang, Xiaodong Gao, Honghai Zhang, Zhengting Zou, Shu-Jin Luo

PLOS Genetics: published August 30, 2021 | https://doi.org/10.1371/journal.pgen.1009770

Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans

Peter A. Kropp, Jing Wu, Michael Reidy, Sanjay Shrestha, Kyle Rhodehouse, Philippa Rogers, Michael N. Sack, Andy Golden

PLOS Genetics: published August 27, 2021 | https://doi.org/10.1371/journal.pgen.1009771

The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans

Mennatallah M. Y. Albarqi, Sean P. Ryder

PLOS Genetics: published August 23, 2021 | https://doi.org/10.1371/journal.pgen.1009775

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase

Christopher M. Witham, Aleshanee L. Paxman, Lamprini Baklous, Robert F. L. Steuart, Benjamin L. Schulz, Carl J. Mousley

PLOS Genetics: published August 30, 2021 | https://doi.org/10.1371/journal.pgen.1009780

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements

David A. Ellis, Félix Reyes-Martín, María Rodríguez-López, Cristina Cotobal, Xi-Ming Sun, Quentin Saintain, Daniel C. Jeffares, Samuel Marguerat, Víctor A. Tallada, Jürg Bähler

PLOS Genetics: published August 31, 2021 | https://doi.org/10.1371/journal.pgen.1009784

Uterine Notch2 facilitates pregnancy recognition and corpus luteum maintenance via upregulating decidual Prl8a2

Haili Bao, Yang Sun, Ningjie Yang, Na Deng, Zhangli Ni, Yedong Tang, Gaizhen Li, Lili Du, Yan-Ling Wang, Dunjin Chen, Haibin Wang, Shuangbo Kong

PLOS Genetics: published August 30, 2021 | https://doi.org/10.1371/journal.pgen.1009786

Retraction: Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes

Xuezhao Liu, Limin Yin, Tianyou Li, Lingxi Lin, Jie Zhang, Yang Li

PLOS Genetics: published August 17, 2021 | https://doi.org/10.1371/journal.pgen.1009746

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1. Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes

Exploiting collider bias to apply two-sample summary data Mendelian randomization methods to one-sample individual level data

Ciarrah Barry, Junxi Liu, Rebecca Richmond, Martin K. Rutter, Deborah A. Lawlor, Frank Dudbridge, Jack Bowden

PLOS Genetics: published August 9, 2021 | https://doi.org/10.1371/journal.pgen.1009703