To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase

Alan Herbert

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009513

Related Articles

1. RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

Gene action, genetic variation, and GWAS: A user-friendly web tool

Valentin Hivert, Naomi R. Wray, Peter M. Visscher

PLOS Genetics: published May 20, 2021 | https://doi.org/10.1371/journal.pgen.1009548

RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis

Miguel Hernandez Sanchez-Rebato, Alida M. Bouatta, Maria E. Gallego, Charles I. White, Olivier Da Ines

PLOS Genetics: published May 18, 2021 | https://doi.org/10.1371/journal.pgen.1008919

Evaluation of polygenic prediction methodology within a reference-standardized framework

Oliver Pain, Kylie P. Glanville, Saskia P. Hagenaars, Saskia Selzam, Anna E. Fürtjes, Héléna A. Gaspar, Jonathan R. I. Coleman, Kaili Rimfeld, Gerome Breen, Robert Plomin, Lasse Folkersen, Cathryn M. Lewis

PLOS Genetics: published May 4, 2021 | https://doi.org/10.1371/journal.pgen.1009021

Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei

Manisha Sinha, Ankita Shree, Kunal Singh, Kamal Kumar, Shreenivas Kumar Singh, Vimlesh Kumar, Praveen Kumar Verma

PLOS Genetics: published May 17, 2021 | https://doi.org/10.1371/journal.pgen.1009137

CENP-C functions in centromere assembly, the maintenance of CENP-A asymmetry and epigenetic age in Drosophila germline stem cells

Ben L. Carty, Anna A. Dattoli, Elaine M. Dunleavy

PLOS Genetics: published May 20, 2021 | https://doi.org/10.1371/journal.pgen.1009247

Regulation of the plastochron by three many-noded dwarf genes in barley

Ken-ichiro Hibara, Masayuki Miya, Sean Akira Benvenuto, Naoko Hibara-Matsuo, Manaki Mimura, Takanori Yoshikawa, Masaharu Suzuki, Makoto Kusaba, Shin Taketa, Jun-ichi Itoh

PLOS Genetics: published May 10, 2021 | https://doi.org/10.1371/journal.pgen.1009292

KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice

Seiya Oura, Takayuki Koyano, Chisato Kodera, Yuki Horisawa-Takada, Makoto Matsuyama, Kei-ichiro Ishiguro, Masahito Ikawa

PLOS Genetics: published May 7, 2021 | https://doi.org/10.1371/journal.pgen.1009412

Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Hannah Currant, Pirro Hysi, Tomas W. Fitzgerald, Puya Gharahkhani, Pieter W. M. Bonnemaijer, Anne Senabouth, Alex W. Hewitt, UK Biobank Eye and Vision Consortium, International Glaucoma Genetics Consortium, Denize Atan, Tin Aung, Jason Charng, Hélène Choquet, Jamie Craig, Peng T. Khaw, Caroline C. W. Klaver, Michiaki Kubo, Jue-Sheng Ong, Louis R. Pasquale, Charles A. Reisman, Maciej Daniszewski, Joseph E. Powell, Alice Pébay, Mark J. Simcoe, Alberta A. H. J. Thiadens, Cornelia M. van Duijn, Seyhan Yazar, Eric Jorgenson, Stuart MacGregor, Chris J. Hammond, David A. Mackey, Janey L. Wiggs, Paul J. Foster, Praveen J. Patel, Ewan Birney, Anthony P. Khawaja

PLOS Genetics: published May 12, 2021 | https://doi.org/10.1371/journal.pgen.1009497

Related Articles

1. Correction: Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images

Comparative analysis reveals distinctive epigenetic features of the human cerebellum

Elaine E. Guevara, William D. Hopkins, Patrick R. Hof, John J. Ely, Brenda J. Bradley, Chet C. Sherwood

PLOS Genetics: published May 6, 2021 | https://doi.org/10.1371/journal.pgen.1009506

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009516

Related Articles

1. To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase

Genotype-phenotype correlation in neurofibromatosis type-1: NF1 whole gene deletions lead to high tumor-burden and increased tumor-growth

Lennart Well, Kimberly Döbel, Lan Kluwe, Peter Bannas, Said Farschtschi, Gerhard Adam, Victor-Felix Mautner, Johannes Salamon

PLOS Genetics: published May 5, 2021 | https://doi.org/10.1371/journal.pgen.1009517

3D facial phenotyping by biometric sibling matching used in contemporary genomic methodologies

Hanne Hoskens, Dongjing Liu, Sahin Naqvi, Myoung Keun Lee, Ryan J. Eller, Karlijne Indencleef, Julie D. White, Jiarui Li, Maarten H. D. Larmuseau, Greet Hens, Joanna Wysocka, Susan Walsh, Stephen Richmond, Mark D. Shriver, John R. Shaffer, Hilde Peeters, Seth M. Weinberg, Peter Claes

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009528

Whole genome sequencing of a snailfish from the Yap Trench (~7,000 m) clarifies the molecular mechanisms underlying adaptation to the deep sea

Yinnan Mu, Chao Bian, Ruoyu Liu, Yuguang Wang, Guangming Shao, Jia Li, Ying Qiu, Tianliang He, Wanru Li, Jingqun Ao, Qiong Shi, Xinhua Chen

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009530

Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes

Anthony Aylward, Mei-Lin Okino, Paola Benaglio, Joshua Chiou, Elisha Beebe, Jose Andres Padilla, Sharlene Diep, Kyle J. Gaulton

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009531

Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1

Zhenzhen Zhang, Ying Sun, Xue Jiang, Wenfei Wang, Zhi-Yong Wang

PLOS Genetics: published May 14, 2021 | https://doi.org/10.1371/journal.pgen.1009540

Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

Jacquelyn M. Evans, Heidi G. Parker, Gerard R. Rutteman, Jocelyn Plassais, Guy C. M. Grinwis, Alexander C. Harris, Susan E. Lana, Elaine A. Ostrander

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009543

Light-dependent N-end rule-mediated disruption of protein function in Saccharomyces cerevisiae and Drosophila melanogaster

Leslie M. Stevens, Goheun Kim, Theodora Koromila, John W. Steele, James McGehee, Angelike Stathopoulos, David S. Stein

PLOS Genetics: published May 17, 2021 | https://doi.org/10.1371/journal.pgen.1009544

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer

Navdeep Malik, Hualong Yan, Howard H. Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang

PLOS Genetics: published May 4, 2021 | https://doi.org/10.1371/journal.pgen.1009553

Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes

Shixiang Wang, Huimin Li, Minfang Song, Ziyu Tao, Tao Wu, Zaoke He, Xiangyu Zhao, Kai Wu, Xue-Song Liu

PLOS Genetics: published May 4, 2021 | https://doi.org/10.1371/journal.pgen.1009557

RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila

Jun Xie, Yongchao Han, Tao Wang

PLOS Genetics: published May 13, 2021 | https://doi.org/10.1371/journal.pgen.1009558

DEFECTIVE EMBRYO AND MERISTEMS genes are required for cell division and gamete viability in Arabidopsis

Chin Hong Lee, Nathaniel P. Hawker, Jonathan R. Peters, Thierry G. A. Lonhienne, Nial R. Gursanscky, Louisa Matthew, Christopher A. Brosnan, Christopher W. G. Mann, Laurence Cromer, Christelle Taochy, Quy A. Ngo, Venkatesan Sundaresan, Peer M. Schenk, Bostjan Kobe, Filipe Borges, Raphael Mercier, John L. Bowman, Bernard J. Carroll

PLOS Genetics: published May 17, 2021 | https://doi.org/10.1371/journal.pgen.1009561

The Exon Junction Complex and intron removal prevent re-splicing of mRNA

Brian Joseph, Eric C. Lai

PLOS Genetics: published May 25, 2021 | https://doi.org/10.1371/journal.pgen.1009563

Drainage-structuring of ancestral variation and a common functional pathway shape limited genomic convergence in natural high- and low-predation guppies

James R. Whiting, Josephine R. Paris, Mijke J. van der Zee, Paul J. Parsons, Detlef Weigel, Bonnie A. Fraser

PLOS Genetics: published May 24, 2021 | https://doi.org/10.1371/journal.pgen.1009566

A degron-based strategy reveals new insights into Aurora B function in C. elegans

Nikita S. Divekar, Amanda C. Davis-Roca, Liangyu Zhang, Abby F. Dernburg, Sarah M. Wignall

PLOS Genetics: published May 20, 2021 | https://doi.org/10.1371/journal.pgen.1009567

The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes

Kanako Kibe, Kenjiro Shirane, Hiroaki Ohishi, Shuhei Uemura, Hidehiro Toh, Hiroyuki Sasaki

PLOS Genetics: published May 28, 2021 | https://doi.org/10.1371/journal.pgen.1009570

Phosphatidylcholine mediates the crosstalk between LET-607 and DAF-16 stress response pathways

Bin He, Jie Xu, Shanshan Pang, Haiqing Tang

PLOS Genetics: published May 20, 2021 | https://doi.org/10.1371/journal.pgen.1009573

Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria

Zalak Shah, Myo T. Naung, Kara A. Moser, Matthew Adams, Andrea G. Buchwald, Ankit Dwivedi, Amed Ouattara, Karl B. Seydel, Don P. Mathanga, Alyssa E. Barry, David Serre, Miriam K. Laufer, Joana C. Silva, Shannon Takala-Harrison

PLOS Genetics: published May 25, 2021 | https://doi.org/10.1371/journal.pgen.1009576

Functional-genomic analysis reveals intraspecies diversification of antiviral receptor transporter proteins in Xenopus laevis

Ian N. Boys, Katrina B. Mar, John W. Schoggins

PLOS Genetics: published May 20, 2021 | https://doi.org/10.1371/journal.pgen.1009578

Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling

Mary E. Swartz, C. Ben Lovely, Johann K. Eberhart

PLOS Genetics: published May 25, 2021 | https://doi.org/10.1371/journal.pgen.1009579

Evolution of plasticity in production and transgenerational inheritance of small RNAs under dynamic environmental conditions

Willian T. A. F. Silva, Sarah P. Otto, Simone Immler

PLOS Genetics: published May 26, 2021 | https://doi.org/10.1371/journal.pgen.1009581

The pluripotent stem cell-specific transcript ESRG is dispensable for human pluripotency

Kazutoshi Takahashi, Michiko Nakamura, Chikako Okubo, Zane Kliesmete, Mari Ohnuki, Megumi Narita, Akira Watanabe, Mai Ueda, Yasuhiro Takashima, Ines Hellmann, Shinya Yamanaka

PLOS Genetics: published May 25, 2021 | https://doi.org/10.1371/journal.pgen.1009587

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase

Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang

PLOS Genetics: published May 25, 2021 | https://doi.org/10.1371/journal.pgen.1009592

Correction: Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori

Kai Chen, Ye Yu, Dehong Yang, Xu Yang, Linmeng Tang, Yujia Liu, Xingyu Luo, James R. Walters, Zulian Liu, Jun Xu, Yongping Huang

PLOS Genetics: published May 17, 2021 | https://doi.org/10.1371/journal.pgen.1009572

Related Articles

1. Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori