Kingdom Come

Gregory S. Barsh, Gregory P. Copenhaver, Claudia Köhler, Li-Jia Qu

PLOS Genetics: published November 5, 2020 | https://doi.org/10.1371/journal.pgen.1009178

New insights into the function of mammalian Argonaute2

Marek Marzec

PLOS Genetics: published November 12, 2020 | https://doi.org/10.1371/journal.pgen.1009058

Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis

Audrey Gerstel, Jordi Zamarreño Beas, Yohann Duverger, Emmanuelle Bouveret, Frédéric Barras, Béatrice Py

PLOS Genetics: published November 2, 2020 | https://doi.org/10.1371/journal.pgen.1009198

NIGT1 family proteins exhibit dual mode DNA recognition to regulate nutrient response-associated genes in Arabidopsis

Yoshiaki Ueda, Shohei Nosaki, Yasuhito Sakuraba, Takuya Miyakawa, Takatoshi Kiba, Masaru Tanokura, Shuichi Yanagisawa

PLOS Genetics: published November 2, 2020 | https://doi.org/10.1371/journal.pgen.1009197

Genetic engineering of sex chromosomes for batch cultivation of non-transgenic, sex-sorted males

Siba R. Das, Maciej Maselko, Ambuj Upadhyay, Michael J. Smanski

PLOS Genetics: published November 2, 2020 | https://doi.org/10.1371/journal.pgen.1009180

A spectrum of verticality across genes

Falk S. P. Nagies, Julia Brueckner, Fernando D. K. Tria, William F. Martin

PLOS Genetics: published November 2, 2020 | https://doi.org/10.1371/journal.pgen.1009200

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Federica Diofano, Karolina Weinmann, Isabelle Schneider, Kevin D. Thiessen, Wolfgang Rottbauer, Steffen Just

PLOS Genetics: published November 2, 2020 | https://doi.org/10.1371/journal.pgen.1009088

Mutations in PIH proteins MOT48, TWI1 and PF13 define common and unique steps for preassembly of each, different ciliary dynein

Ryosuke Yamamoto, Shiho Yanagi, Masahito Nagao, Yuya Yamasaki, Yui Tanaka, Winfield S. Sale, Toshiki Yagi, Takahide Kon

PLOS Genetics: published November 3, 2020 | https://doi.org/10.1371/journal.pgen.1009126

A C. elegans Zona Pellucida domain protein functions via its ZPc domain

Jennifer D. Cohen, Jessica G. Bermudez, Matthew C. Good, Meera V. Sundaram

PLOS Genetics: published November 3, 2020 | https://doi.org/10.1371/journal.pgen.1009188

A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer

Anaïs Assouvie, Maxime Rotival, Juliette Hamroune, Didier Busso, Paul-Henri Romeo, Lluis Quintana-Murci, Germain Rousselet

PLOS Genetics: published November 4, 2020 | https://doi.org/10.1371/journal.pgen.1009090

Loss of hepatocyte cell division leads to liver inflammation and fibrosis

Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi, Philipp Kaldis

PLOS Genetics: published November 4, 2020 | https://doi.org/10.1371/journal.pgen.1009084

A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease

Tanja Mederer, Stefanie Schmitteckert, Julia Volz, Cristina Martínez, Ralph Röth, Thomas Thumberger, Volker Eckstein, Jutta Scheuerer, Cornelia Thöni, Felix Lasitschka, Leonie Carstensen, Patrick Günther, Stefan Holland-Cunz, Robert Hofstra, Erwin Brosens, Jill A. Rosenfeld, Christian P. Schaaf, Duco Schriemer, Isabella Ceccherini, Marta Rusmini, Joseph Tilghman, Berta Luzón-Toro, Ana Torroglosa, Salud Borrego, Clara Sze-man Tang, Mercè Garcia-Barceló, Paul Tam, Nagarajan Paramasivam, Melanie Bewerunge-Hudler, Carolina De La Torre, Norbert Gretz, Gudrun A. Rappold, Philipp Romero, Beate Niesler

PLOS Genetics: published November 5, 2020 | https://doi.org/10.1371/journal.pgen.1009106

The Bric-à-Brac BTB/POZ transcription factors are necessary in niche cells for germline stem cells establishment and homeostasis through control of BMP/DPP signaling in the Drosophila melanogaster ovary

Laurine Miscopein Saler, Virginie Hauser, Mathieu Bartoletti, Charlotte Mallart, Marianne Malartre, Laura Lebrun, Anne-Marie Pret, Laurent Théodore, Fabienne Chalvet, Sophie Netter

PLOS Genetics: published November 5, 2020 | https://doi.org/10.1371/journal.pgen.1009128

The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits

Vinutha K. Balachandra, Jiyoti Verma, Madhu Shankar, Timothy M. Tucey, Ana Traven, Ralf B. Schittenhelm, Santanu K. Ghosh

PLOS Genetics: published November 5, 2020 | https://doi.org/10.1371/journal.pgen.1009071

A frog with three sex chromosomes that co-mingle together in nature: Xenopus tropicalis has a degenerate W and a Y that evolved from a Z chromosome

Benjamin L. S. Furman, Caroline M. S. Cauret, Martin Knytl, Xue-Ying Song, Tharindu Premachandra, Caleb Ofori-Boateng, Danielle C. Jordan, Marko E. Horb, Ben J. Evans

PLOS Genetics: published November 9, 2020 | https://doi.org/10.1371/journal.pgen.1009121

A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics

Daniel C. Maddison, Mónica Alfonso-Núñez, Aisha M. Swaih, Carlo Breda, Susanna Campesan, Natalie Allcock, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Flaviano Giorgini

PLOS Genetics: published November 10, 2020 | https://doi.org/10.1371/journal.pgen.1009129

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans

Kathryn S. Evans, Stefan Zdraljevic, Lewis Stevens, Kimberly Collins, Robyn E. Tanny, Erik C. Andersen

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1008986

Phosphoregulation of HORMA domain protein HIM-3 promotes asymmetric synaptonemal complex disassembly in meiotic prophase in Caenorhabditis elegans

Aya Sato-Carlton, Chihiro Nakamura-Tabuchi, Xuan Li, Hendrik Boog, Madison K. Lehmer, Scott C. Rosenberg, Consuelo Barroso, Enrique Martinez-Perez, Kevin D. Corbett, Peter Mark Carlton

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1008968

Microutrophin expression in dystrophic mice displays myofiber type differences in therapeutic effects

Glen B. Banks, Jeffrey S. Chamberlain, Guy L. Odom

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1009179

LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks

Jeffery A. Goldstein, Joshua S. Weinstock, Lisa A. Bastarache, Daniel B. Larach, Lars G. Fritsche, Ellen M. Schmidt, Chad M. Brummett, Sachin Kheterpal, Goncalo R. Abecasis, Joshua C. Denny, Matthew Zawistowski

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1009077

Selection of GmSWEET39 for oil and protein improvement in soybean

Hengyou Zhang, Wolfgang Goettel, Qijian Song, He Jiang, Zhenbin Hu, Ming Li Wang, Yong-qiang Charles An

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1009114

The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

Gloria Gonzalez Curto, Audrey Der Vartanian, Youcef El-Mokhtar Frarma, Line Manceau, Lorenzo Baldi, Selene Prisco, Nabila Elarouci, Frédéric Causeret, Daniil Korenkov, Muriel Rigolet, Frédéric Aurade, Aurélien De Reynies, Vincent Contremoulins, Frédéric Relaix, Orestis Faklaris, James Briscoe, Pascale Gilardi-Hebenstreit, Vanessa Ribes

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1009164

Hypomethylation of GDNF family receptor alpha 1 promotes epithelial-mesenchymal transition and predicts metastasis of colorectal cancer

Zhexu Dong, Lei Dai, Yong Zhang, Chao Fang, Gang Shi, Ye Chen, Junshu Li, Qin Wang, Jiamei Fu, Yan Yu, Wenshuang Wang, Lin Cheng, Yi Liu, Yi Lin, Yuan Wang, Qingnan Wang, Huiling Wang, Hantao Zhang, Yujing Zhang, Xiaolan Su, Shuang Zhang, Feng Wang, Meng Qiu, Zongguang Zhou, Hongxin Deng

PLOS Genetics: published November 11, 2020 | https://doi.org/10.1371/journal.pgen.1009159

Meiosis reveals the early steps in the evolution of a neo-XY sex chromosome pair in the African pygmy mouse Mus minutoides

Ana Gil-Fernández, Paul A. Saunders, Marta Martín-Ruiz, Marta Ribagorda, Pablo López-Jiménez, Daniel L. Jeffries, María Teresa Parra, Alberto Viera, Julio S. Rufas, Nicolas Perrin, Frederic Veyrunes, Jesús Page

PLOS Genetics: published November 12, 2020 | https://doi.org/10.1371/journal.pgen.1008959

Two cis-regulatory SNPs upstream of ABCG2 synergistically cause the blue eggshell phenotype in the duck

Li Chen, Xiaorong Gu, Xuetao Huang, Rui Liu, Jinxiu Li, Yiqing Hu, Guoqin Li, Tao Zeng, Yong Tian, Xiaoxiang Hu, Lizhi Lu, Ning Li

PLOS Genetics: published November 13, 2020 | https://doi.org/10.1371/journal.pgen.1009119

Identity-by-descent with uncertainty characterises connectivity of Plasmodium falciparum populations on the Colombian-Pacific coast

Aimee R. Taylor, Diego F. Echeverry, Timothy J. C. Anderson, Daniel E. Neafsey, Caroline O. Buckee

PLOS Genetics: published November 16, 2020 | https://doi.org/10.1371/journal.pgen.1009101

Genotype imputation using the Positional Burrows Wheeler Transform

Simone Rubinacci, Olivier Delaneau, Jonathan Marchini

PLOS Genetics: published November 16, 2020 | https://doi.org/10.1371/journal.pgen.1009049

Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells

M. Carmen Lafita-Navarro, Niranjan Venkateswaran, Jessica A. Kilgore, Suman Kanji, Jungsoo Han, Spencer Barnes, Noelle S. Williams, Michael Buszczak, Sandeep Burma, Maralice Conacci-Sorrell

PLOS Genetics: published November 17, 2020 | https://doi.org/10.1371/journal.pgen.1009117

Multivariable G-E interplay in the prediction of educational achievement

Andrea G. Allegrini, Ville Karhunen, Jonathan R. I. Coleman, Saskia Selzam, Kaili Rimfeld, Sophie von Stumm, Jean-Baptiste Pingault, Robert Plomin

PLOS Genetics: published November 17, 2020 | https://doi.org/10.1371/journal.pgen.1009153

Stability of SARS-CoV-2 phylogenies

Yatish Turakhia, Nicola De Maio, Bryan Thornlow, Landen Gozashti, Robert Lanfear, Conor R. Walker, Angie S. Hinrichs, Jason D. Fernandes, Rui Borges, Greg Slodkowicz, Lukas Weilguny, David Haussler, Nick Goldman, Russell Corbett-Detig

PLOS Genetics: published November 18, 2020 | https://doi.org/10.1371/journal.pgen.1009175

The DNA damage response is required for oocyte cyst breakdown and follicle formation in mice

Ana Martínez-Marchal, Yan Huang, Maria Teresa Guillot-Ferriols, Mònica Ferrer-Roda, Anna Guixé, Montserrat Garcia-Caldés, Ignasi Roig

PLOS Genetics: published November 18, 2020 | https://doi.org/10.1371/journal.pgen.1009067

Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells

Rohan Chippalkatti, Boris Egger, Beat Suter

PLOS Genetics: published November 19, 2020 | https://doi.org/10.1371/journal.pgen.1008913

Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles

Alejandro Martin-Trujillo, Nihir Patel, Felix Richter, Bharati Jadhav, Paras Garg, Sarah U. Morton, David M. McKean, Steven R. DePalma, Elizabeth Goldmuntz, Dorota Gruber, Richard Kim, Jane W. Newburger, George A. Porter Jr., Alessandro Giardini, Daniel Bernstein, Martin Tristani-Firouzi, Jonathan G. Seidman, Christine E. Seidman, Wendy K. Chung, Bruce D. Gelb, Andrew J. Sharp

PLOS Genetics: published November 20, 2020 | https://doi.org/10.1371/journal.pgen.1009189

No association between SCN9A and monogenic human epilepsy disorders

James Fasham, Joseph S. Leslie, Jamie W. Harrison, James Deline, Katie B. Williams, Ashley Kuhl, Jessica Scott Schwoerer, Harold E. Cross, Andrew H. Crosby, Emma L. Baple

PLOS Genetics: published November 20, 2020 | https://doi.org/10.1371/journal.pgen.1009161

Unique genetic signatures of local adaptation over space and time for diapause, an ecologically relevant complex trait, in Drosophila melanogaster

Priscilla A. Erickson, Cory A. Weller, Daniel Y. Song, Alyssa S. Bangerter, Paul Schmidt, Alan O. Bergland

PLOS Genetics: published November 20, 2020 | https://doi.org/10.1371/journal.pgen.1009110

A phenome-wide association study of 26 mendelian genes reveals phenotypic expressivity of common and rare variants within the general population

Catherine Tcheandjieu, Matthew Aguirre, Stefan Gustafsson, Priyanka Saha, Praneetha Potiny, Melissa Haendel, Erik Ingelsson, Manuel A. Rivas, James R. Priest

PLOS Genetics: published November 23, 2020 | https://doi.org/10.1371/journal.pgen.1008802

Innate immune signaling in Drosophila shifts anabolic lipid metabolism from triglyceride storage to phospholipid synthesis to support immune function

Brittany A. Martínez, Rosalie G. Hoyle, Scott Yeudall, Mitchell E. Granade, Thurl E. Harris, J. David Castle, Norbert Leitinger, Michelle L. Bland

PLOS Genetics: published November 23, 2020 | https://doi.org/10.1371/journal.pgen.1009192

Genome-wide association study identifies 16 genomic regions associated with circulating cytokines at birth

Yunpeng Wang, Ron Nudel, Michael E. Benros, Kristin Skogstrand, Simon Fishilevich, iPSYCH-BROAD, Doron Lancet, Jiangming Sun, David M. Hougaard, Ole A. Andreassen, Preben Bo Mortensen, Alfonso Buil, Thomas F. Hansen, Wesley K. Thompson, Thomas Werge

PLOS Genetics: published November 23, 2020 | https://doi.org/10.1371/journal.pgen.1009163

A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition

Chudong Wu, Jean-François Boisclair Lachance, Michael Z. Ludwig, Ilaria Rebay

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1009216

Mosquito genomes are frequently invaded by transposable elements through horizontal transfer

Elverson Soares de Melo, Gabriel Luz Wallau

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1008946

Phenomic screen identifies a role for the yeast lysine acetyltransferase NuA4 in the control of Bcy1 subcellular localization, glycogen biosynthesis, and mitochondrial morphology

Elizabeth A. Walden, Roger Y. Fong, Trang T. Pham, Hana Knill, Sarah Jane Laframboise, Sylvain Huard, Mary-Ellen Harper, Kristin Baetz

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1009220

Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts

Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1009169

Involvement of glycogen metabolism in circadian control of UV resistance in cyanobacteria

Koji Kawasaki, Hideo Iwasaki

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1009230

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

Ivana Bjedov, Helena M. Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S. Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C. Regan, Janne M. Toivonen, Michael P. Murphy, Janet Thornton, Kerri J. Kinghorn, Thomas P. Neufeld, Filipe Cabreiro, Linda Partridge

PLOS Genetics: published November 30, 2020 | https://doi.org/10.1371/journal.pgen.1009083

Formal commentary

Gustavo D. Aguirre, Hannes Lohi, Maria Kaukonen, Leonardo Murgiano

PLOS Genetics: published November 5, 2020 | https://doi.org/10.1371/journal.pgen.1009059

Related Articles

1. A putative silencer variant in a spontaneous canine model of retinitis pigmentosa