A mutant form of Dmc1 that bypasses the requirement for accessory protein Mei5-Sae3 reveals independent activities of Mei5-Sae3 and Rad51 in Dmc1 filament stability

Diedre Reitz, Jennifer Grubb, Douglas K. Bishop

PLOS Genetics: published December 2, 2019 | https://doi.org/10.1371/journal.pgen.1008217

Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway

Juliana Sucharov, Kuval Ray, Elliott P. Brooks, James T. Nichols

PLOS Genetics: published December 2, 2019 | https://doi.org/10.1371/journal.pgen.1008507

The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain

Robert Fredriksson, Smitha Sreedharan, Karin Nordenankar, Johan Alsiö, Frida A. Lindberg, Ashley Hutchinson, Anders Eriksson, Sahar Roshanbin, Diana M. Ciuculete, Anica Klockars, Aniruddha Todkar, Maria G. Hägglund, Sofie V. Hellsten, Viktoria Hindlycke, Åke Västermark, Ganna Shevchenko, Gaia Olivo, Cheng K, Klas Kullander, Ali Moazzami, Jonas Bergquist, Pawel K. Olszewski, Helgi B. Schiöth

PLOS Genetics: published December 4, 2019 | https://doi.org/10.1371/journal.pgen.1008455

An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior

Tyler Buddell, Vladislav Friedman, Cody J. Drozd, Christopher C. Quinn

PLOS Genetics: published December 5, 2019 | https://doi.org/10.1371/journal.pgen.1008488

Modulators of hormonal response regulate temporal fate specification in the Drosophila brain

Giovanni Marchetti, Gaia Tavosanis

PLOS Genetics: published December 6, 2019 | https://doi.org/10.1371/journal.pgen.1008491

An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs

Miao Tian, Josef Loidl

PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008514

Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism

Malgorzata Jedrychowska, Milena Denkiewicz-Kruk, Malgorzata Alabrudzinska, Adrianna Skoneczna, Piotr Jonczyk, Michal Dmowski, Iwona J. Fijalkowska

PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008494

Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer Margaret Grants, Xuanjin Cheng, Deema Alhusari, Forum Bhanshali, Amy Fong-Yuk Poon, Michelle Ying Ya Lee, Anik Muhuri, Jung In Park, James Shih, Dongyeop Lee, Seung-Jae V. Lee, Francis Christopher Lynn, Stefan Taubert

PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008508

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval

Emily A. King, J. Wade Davis, Jacob F. Degner

PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008489

Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization

Leslie Dunipace, Zsuzsa Ákos, Angelike Stathopoulos

PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008525

A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21

Jonathan M. Chernus, Emily G. Allen, Zhen Zeng, Eva R. Hoffman, Terry J. Hassold, Eleanor Feingold, Stephanie L. Sherman

PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008414

Leveraging allelic imbalance to refine fine-mapping for eQTL studies

Jennifer Zou, Farhad Hormozdiari, Brandon Jew, Stephane E. Castel, Tuuli Lappalainen, Jason Ernst, Jae Hoon Sul, Eleazar Eskin

PLOS Genetics: published December 13, 2019 | https://doi.org/10.1371/journal.pgen.1008481

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

Nicole F. Liachko, Aleen D. Saxton, Pamela J. McMillan, Timothy J. Strovas, C. Dirk Keene, Thomas D. Bird, Brian C. Kraemer

PLOS Genetics: published December 13, 2019 | https://doi.org/10.1371/journal.pgen.1008526

Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children

Anders Kämpe, Maria Enlund-Cerullo, Saara Valkama, Elisa Holmlund-Suila, Jenni Rosendahl, Helena Hauta-alus, Minna Pekkinen, Sture Andersson, Outi Mäkitie

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008530

APOBEC3A is a prominent cytidine deaminase in breast cancer

Luis M. Cortez, Amber L. Brown, Madeline A. Dennis, Christopher D. Collins, Alexander J. Brown, Debra Mitchell, Tony M. Mertz, Steven A. Roberts

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008545

Hybridization promotes asexual reproduction in Caenorhabditis nematodes

Piero Lamelza, Janet M. Young, Luke M. Noble, Lews Caro, Arielle Isakharov, Meenakshi Palanisamy, Matthew V. Rockman, Harmit S. Malik, Michael Ailion

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008520

Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes

Jan Henkel, Rashid Saif, Vidhya Jagannathan, Corinne Schmocker, Flurina Zeindler, Erika Bangerter, Ursula Herren, Dimitris Posantzis, Zafer Bulut, Philippe Ammann, Cord Drögemüller, Christine Flury, Tosso Leeb

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008536

zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage

Sebastian E. Rojas Villa, Fanju W. Meng, Benoît Biteau

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008553

Drosophila RpS12 controls translation, growth, and cell competition through Xrp1

Zhejun Ji, Marianthi Kiparaki, Virginia Folgado, Amit Kumar, Jorge Blanco, Gerard Rimesso, Jacky Chuen, Yang Liu, Deyou Zheng, Nicholas E. Baker

PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008513

A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival

Rodrigo Guarischi-Sousa, Jhonatas S. Monteiro, Lilian C. Alecrim, Jussara S. Michaloski, Laura B. Cardeal, Elisa N. Ferreira, Dirce M. Carraro, Diana N. Nunes, Emmanuel Dias-Neto, Jüri Reimand, Paul C. Boutros, João C. Setubal, Ricardo J. Giordano

PLOS Genetics: published December 17, 2019 | https://doi.org/10.1371/journal.pgen.1008482

Experimental population modification of the malaria vector mosquito, Anopheles stephensi

Thai Binh Pham, Celine Hien Phong, Jared B. Bennett, Kristy Hwang, Nijole Jasinskiene, Kiona Parker, Drusilla Stillinger, John M. Marshall, Rebeca Carballar-Lejarazú, Anthony A. James

PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008440

Latent transcriptional variations of individual Plasmodium falciparum uncovered by single-cell RNA-seq and fluorescence imaging

Katelyn A. Walzer, Hélène Fradin, Liane Y. Emerson, David L. Corcoran, Jen-Tsan Chi

PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008506

Identification of novel genes involved in phosphate accumulation in Lotus japonicus through Genome Wide Association mapping of root system architecture and anion content

Marco Giovannetti, Christian Göschl, Christof Dietzen, Stig U. Andersen, Stanislav Kopriva, Wolfgang Busch

PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008126

Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes

Eliska Taborska, Josef Pasulka, Radek Malik, Filip Horvat, Irena Jenickova, Zoe Jelić Matošević, Petr Svoboda

PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008261

Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives

Madison Caballero, Daniel N. Seidman, Ying Qiao, Jens Sannerud, Thomas D. Dyer, Donna M. Lehman, Joanne E. Curran, Ravindranath Duggirala, John Blangero, Shai Carmi, Amy L. Williams

PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1007979

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

Annick Guiseppi, Juan Jesus Vicente, Julien Herrou, Deborah Byrne, Aurelie Barneoud, Audrey Moine, Leon Espinosa, Marie-Jeanne Basse, Virginie Molle, Tâm Mignot, Philippe Roche, Emilia M. F. Mauriello

PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008533

Common gardens in teosintes reveal the establishment of a syndrome of adaptation to altitude

Margaux-Alison Fustier, Natalia E. Martínez-Ainsworth, Jonás A. Aguirre-Liguori, Anthony Venon, Hélène Corti, Agnès Rousselet, Fabrice Dumas, Hannes Dittberner, María G. Camarena, Daniel Grimanelli, Otso Ovaskainen, Matthieu Falque, Laurence Moreau, Juliette de Meaux, Salvador Montes-Hernández, Luis E. Eguiarte, Yves Vigouroux, Domenica Manicacci, Maud I. Tenaillon

PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008512

Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

Madeline H. Kowalski, Huijun Qian, Ziyi Hou, Jonathan D. Rosen, Amanda L. Tapia, Yue Shan, Deepti Jain, Maria Argos, Donna K. Arnett, Christy Avery, Kathleen C. Barnes, Lewis C. Becker, Stephanie A. Bien, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Steve Buyske, Jianwen Cai, Michael H. Cho, Seung Hoan Choi, Hélène Choquet, L. Adrienne Cupples, Mary Cushman, Michelle Daya, Paul S. de Vries, Patrick T. Ellinor, Nauder Faraday, Myriam Fornage, Stacey Gabriel, Santhi K. Ganesh, Misa Graff, Namrata Gupta, Jiang He, Susan R. Heckbert, Bertha Hidalgo, Chani J. Hodonsky, Marguerite R. Irvin, Andrew D. Johnson, Eric Jorgenson, Robert Kaplan, Sharon L. R. Kardia, Tanika N. Kelly, Charles Kooperberg, Jessica A. Lasky-Su, Ruth J. F. Loos, Steven A. Lubitz, Rasika A. Mathias, Caitlin P. McHugh, Courtney Montgomery, Jee-Young Moon, Alanna C. Morrison, Nicholette D. Palmer, Nathan Pankratz, George J. Papanicolaou, Juan M. Peralta, Patricia A. Peyser, Stephen S. Rich, Jerome I. Rotter, Edwin K. Silverman, Jennifer A. Smith, Nicholas L. Smith, Kent D. Taylor, Timothy A. Thornton, Hemant K. Tiwari, Russell P. Tracy, Tao Wang, Scott T. Weiss, Lu-Chen Weng, Kerri L. Wiggins, James G. Wilson, Lisa R. Yanek, Sebastian Zöllner, Kari E. North, Paul L. Auer, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, Laura M. Raffield, Alexander P. Reiner, Yun Li

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008500

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity

Hadi Maazi, Jaana A. Hartiala, Yuzo Suzuki, Amanda L. Crow, Pedram Shafiei Jahani, Jonathan Lam, Nisheel Patel, Diamanda Rigas, Yi Han, Pin Huang, Eleazar Eskin, Aldons. J. Lusis, Frank D. Gilliland, Omid Akbari, Hooman Allayee

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008528

Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII

Mario Pinar, Ernesto Arias-Palomo, Vivian de los Ríos, Herbert N. Arst Jr, Miguel A. Peñalva

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008557

Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms

Xiao Yang, Jingjing Liang, Long Ding, Xia Li, Sin-Man Lam, Guanghou Shui, Mei Ding, Xun Huang

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008548

Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system

Chris Hadjineophytou, Jan Haug Anonsen, Nelson Wang, Kevin C. Ma, Raimonda Viburiene, Åshild Vik, Odile B. Harrison, Martin C. J. Maiden, Yonatan H. Grad, Michael Koomey

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008532

BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana

Zheng-Hui Hong, Tao Qing, Daniel Schubert, Julia Anna Kleinmanns, Jian-Xiang Liu

PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008563

Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy

Mayank Verma, Yuko Shimizu-Motohashi, Yoko Asakura, James P. Ennen, Jennifer Bosco, Zhiwei Zhou, Guo-Hua Fong, Serene Josiah, Dennis Keefe, Atsushi Asakura

PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008468

Cell elimination strategies upon identity switch via modulation of apterous in Drosophila wing disc

Olga Klipa, Fisun Hamaratoglu

PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008573

CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4

Andrew M. Garrett, Peter J. Bosch, David M. Steffen, Leah C. Fuller, Charles G. Marcucci, Alexis A. Koch, Preeti Bais, Joshua A. Weiner, Robert W. Burgess

PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008554

The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

Elizabeth A. Coe, Jennifer Y. Tan, Michael Shapiro, Pakavarin Louphrasitthiphol, Andrew R. Bassett, Ana C. Marques, Colin R. Goding, Keith W. Vance

PLOS Genetics: published December 27, 2019 | https://doi.org/10.1371/journal.pgen.1008501

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance

Patrícia Alves de Castro, Ana Cristina Colabardini, Adriana Oliveira Manfiolli, Jéssica Chiaratto, Lilian Pereira Silva, Eliciane Cevolani Mattos, Giuseppe Palmisano, Fausto Almeida, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Laura Mellado, Marina Campos Rocha, Michael Bromley, Roberto Nascimento Silva, Gabriel Scalini de Souza, Flávio Vieira Loures, Iran Malavazi, Neil Andrew Brown, Gustavo H. Goldman

PLOS Genetics: published December 30, 2019 | https://doi.org/10.1371/journal.pgen.1008551

Common alleles of CMT2 and NRPE1 are major determinants of CHH methylation variation in Arabidopsis thaliana

Eriko Sasaki, Taiji Kawakatsu, Joseph R. Ecker, Magnus Nordborg

PLOS Genetics: published December 30, 2019 | https://doi.org/10.1371/journal.pgen.1008492

Identification of avoidance genes through neural pathway-specific forward optogenetics

Filipe Marques, Gabriella Saro, Andrei-Stefan Lia, Richard J. Poole, Laurent Falquet, Dominique A. Glauser

PLOS Genetics: published December 31, 2019 | https://doi.org/10.1371/journal.pgen.1008509

Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A. Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S. Legro, Andres Salumets, Mark I. McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, the 23andMe Research Team, Unnur Styrkarsdottir, John R. B. Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M. Lindgren, Corrine K. Welt

PLOS Genetics: published December 5, 2019 | https://doi.org/10.1371/journal.pgen.1008517

Related Articles

1. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria

Correction: Origins of DNA replication

The PLOS Genetics Staff

PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008556

Related Articles

1. Origins of DNA replication

Architecture of the Escherichia coli nucleoid

Subhash C. Verma, Zhong Qian, Sankar L. Adhya

PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008456

Related Articles

1. Correction: Architecture of the Escherichia coli nucleoid