Zebrafish mef2ca mutants display variable craniofacial phenotypes. In this study, we showed that selective breeding for penetrance of mutant phenotypes can rapidly produce strains of fish that are highly sensitive to, or resilient against the deleterious mutation. Comparing the selectively bred strains reveals that artificial selection can change the genetic circuitry. Specifically, the downstream genes her6 and dlx5a are tuned so that the initial dysregulation is later corrected during patterning of the pharyngeal arches, shown here by in situ hybridization and the fli1a:EGFP transgene.
Image Credit: Raisa Bailon, University of Colorado Denver.
Research Articles
A mutant form of Dmc1 that bypasses the requirement for accessory protein Mei5-Sae3 reveals independent activities of Mei5-Sae3 and Rad51 in Dmc1 filament stability
PLOS Genetics: published December 2, 2019 | https://doi.org/10.1371/journal.pgen.1008217
Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway
PLOS Genetics: published December 2, 2019 | https://doi.org/10.1371/journal.pgen.1008507
The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain
PLOS Genetics: published December 4, 2019 | https://doi.org/10.1371/journal.pgen.1008455
An autism-causing calcium channel variant functions with selective autophagy to alter axon targeting and behavior
PLOS Genetics: published December 5, 2019 | https://doi.org/10.1371/journal.pgen.1008488
Modulators of hormonal response regulate temporal fate specification in the Drosophila brain
PLOS Genetics: published December 6, 2019 | https://doi.org/10.1371/journal.pgen.1008491
An MCM family protein promotes interhomolog recombination by preventing precocious intersister repair of meiotic DSBs
PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008514
Defects in the GINS complex increase the instability of repetitive sequences via a recombination-dependent mechanism
PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008494
Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans
PLOS Genetics: published December 9, 2019 | https://doi.org/10.1371/journal.pgen.1008508
Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval
PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008489
Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization
PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008525
A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21
PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008414
Leveraging allelic imbalance to refine fine-mapping for eQTL studies
PLOS Genetics: published December 13, 2019 | https://doi.org/10.1371/journal.pgen.1008481
Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy
PLOS Genetics: published December 13, 2019 | https://doi.org/10.1371/journal.pgen.1008526
Genetic variation in GC and CYP2R1 affects 25-hydroxyvitamin D concentration and skeletal parameters: A genome-wide association study in 24-month-old Finnish children
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008530
APOBEC3A is a prominent cytidine deaminase in breast cancer
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008545
Hybridization promotes asexual reproduction in Caenorhabditis nematodes
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008520
Selection signatures in goats reveal copy number variants underlying breed-defining coat color phenotypes
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008536
zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008553
Drosophila RpS12 controls translation, growth, and cell competition through Xrp1
PLOS Genetics: published December 16, 2019 | https://doi.org/10.1371/journal.pgen.1008513
A transcriptome-based signature of pathological angiogenesis predicts breast cancer patient survival
PLOS Genetics: published December 17, 2019 | https://doi.org/10.1371/journal.pgen.1008482
Experimental population modification of the malaria vector mosquito, Anopheles stephensi
PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008440
Latent transcriptional variations of individual Plasmodium falciparum uncovered by single-cell RNA-seq and fluorescence imaging
PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008506
Identification of novel genes involved in phosphate accumulation in Lotus japonicus through Genome Wide Association mapping of root system architecture and anion content
PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008126
Restricted and non-essential redundancy of RNAi and piRNA pathways in mouse oocytes
PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008261
Crossover interference and sex-specific genetic maps shape identical by descent sharing in close relatives
PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1007979
A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays
PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008533
Common gardens in teosintes reveal the establishment of a syndrome of adaptation to altitude
PLOS Genetics: published December 20, 2019 | https://doi.org/10.1371/journal.pgen.1008512
Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008500
A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008528
Characterization of Aspergillus nidulans TRAPPs uncovers unprecedented similarities between fungi and metazoans and reveals the modular assembly of TRAPPII
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008557
Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008548
Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008532
BLISTER-regulated vegetative growth is dependent on the protein kinase domain of ER stress modulator IRE1A in Arabidopsis thaliana
PLOS Genetics: published December 23, 2019 | https://doi.org/10.1371/journal.pgen.1008563
Inhibition of FLT1 ameliorates muscular dystrophy phenotype by increased vasculature in a mouse model of Duchenne muscular dystrophy
PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008468
Cell elimination strategies upon identity switch via modulation of apterous in Drosophila wing disc
PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008573
CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4
PLOS Genetics: published December 26, 2019 | https://doi.org/10.1371/journal.pgen.1008554
The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor
PLOS Genetics: published December 27, 2019 | https://doi.org/10.1371/journal.pgen.1008501
Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance
PLOS Genetics: published December 30, 2019 | https://doi.org/10.1371/journal.pgen.1008551
Common alleles of CMT2 and NRPE1 are major determinants of CHH methylation variation in Arabidopsis thaliana
PLOS Genetics: published December 30, 2019 | https://doi.org/10.1371/journal.pgen.1008492
Identification of avoidance genes through neural pathway-specific forward optogenetics
PLOS Genetics: published December 31, 2019 | https://doi.org/10.1371/journal.pgen.1008509
Corrections
Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
PLOS Genetics: published December 5, 2019 | https://doi.org/10.1371/journal.pgen.1008517
Related Articles
Correction: Origins of DNA replication
PLOS Genetics: published December 19, 2019 | https://doi.org/10.1371/journal.pgen.1008556
Related Articles
Topic Page
Architecture of the Escherichia coli nucleoid
PLOS Genetics: published December 12, 2019 | https://doi.org/10.1371/journal.pgen.1008456