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February 2019

The image shows wild type haploid S. pombe cells imaged during exponential growth with nuclear envelope visualised using nuclear envelope marker Ish1-yeGFP. Brightfield (magenta), nuclear envelope (yellow). See Cantwell et al.

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Image Credit: Helena Cantwell

Editorials

Making room for opinions

Gregory P. Copenhaver, Gregory S. Barsh

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Research Articles

Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma

Guogui Sun, Xiao Ding, Nan Bi, Zhiwu Wang, Lihong Wu, Wei Zhou, Zitong Zhao, Jingbo Wang, Weimin Zhang, Jing Fan, WenJue Zhang, Xin Dong, Ning Lv, Yongmei Song, Qimin Zhan, LuHua Wang

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A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus

Maria Billini, Jacob Biboy, Juliane Kühn, Waldemar Vollmer, Martin Thanbichler

Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation

Amy E. O’Connell, Maxim V. Gerashchenko, Marie-Francoise O’Donohue, Samantha M. Rosen, Eric Huntzinger, Diane Gleeson, Antonella Galli, Edward Ryder, Siqi Cao, Quinn Murphy, Shideh Kazerounian, Sarah U. Morton, Klaus Schmitz-Abe, Vadim N. Gladyshev, Pierre-Emmanuel Gleizes, Bertrand Séraphin, Pankaj B. Agrawal

Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization

Louise A. C. Millard, Neil M. Davies, Kate Tilling, Tom R. Gaunt, George Davey Smith

Global survey of mobile DNA horizontal transfer in arthropods reveals Lepidoptera as a prime hotspot

Daphné Reiss, Gladys Mialdea, Vincent Miele, Damien M. de Vienne, Jean Peccoud, Clément Gilbert, Laurent Duret, Sylvain Charlat

Transcription-driven chromatin repression of Intragenic transcription start sites

Mathias Nielsen, Ryan Ard, Xueyuan Leng, Maxim Ivanov, Peter Kindgren, Vicent Pelechano, Sebastian Marquardt

Genomic insights into neonicotinoid sensitivity in the solitary bee Osmia bicornis

Katherine Beadle, Kumar Saurabh Singh, Bartlomiej J. Troczka, Emma Randall, Marion Zaworra, Christoph T. Zimmer, Angela Hayward, Rebecca Reid, Laura Kor, Maxie Kohler, Benjamin Buer, David R. Nelson, Martin S. Williamson, T. G. Emyr Davies, Linda M. Field, Ralf Nauen, Chris Bass

Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination

Tianpeng Zhang, Zepeng Zhang, Gong Shengzhao, Xiaocui Li, Haiying Liu, Yong Zhao

Dual functions for the ssDNA-binding protein RPA in meiotic recombination

Baolu Shi, Jiangyang Xue, Hao Yin, Rui Guo, Mengcheng Luo, Lan Ye, Qinghua Shi, Xiaoyan Huang, Mingxi Liu, Jiahao Sha, P. Jeremy Wang

Conformational regulation of Escherichia coli DNA polymerase V by RecA and ATP

Malgorzata M. Jaszczur, Dan D. Vo, Ramunas Stanciauskas, Jeffrey G. Bertram, Adhirath Sikand, Michael M. Cox, Roger Woodgate, Chi H. Mak, Fabien Pinaud, Myron F. Goodman

Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors

Tracy E. Dohn, Padmapriyadarshini Ravisankar, Fouley T. Tirera, Kendall E. Martin, Jacob T. Gafranek, Tiffany B. Duong, Terri L. VanDyke, Melissa Touvron, Lindsey A. Barske, J. Gage Crump, Joshua S. Waxman

Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability

Isabella Cera, Laura Whitton, Gary Donohoe, Derek W. Morris, Georg Dechant, Galina Apostolova

The Drosophila fussel gene is required for bitter gustatory neuron differentiation acting within an Rpd3 dependent chromatin modifying complex

Mathias Rass, Svenja Oestreich, Severin Guetter, Susanne Fischer, Stephan Schneuwly

A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene

Michael Hecker, Nina Boxberger, Nicole Illner, Brit Fitzner, Ina Schröder, Alexander Winkelmann, Ales Dudesek, Stefanie Meister, Dirk Koczan, Peter Lorenz, Hans-Jürgen Thiesen, Uwe Klaus Zettl

Comprehensive structural variation genome map of individuals carrying complex chromosomal rearrangements

Jesper Eisfeldt, Maria Pettersson, Francesco Vezzi, Josephine Wincent, Max Käller, Joel Gruselius, Daniel Nilsson, Elisabeth Syk Lundberg, Claudia M. B. Carvalho, Anna Lindstrand

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Alexandra Bezler, Fabian Braukmann, Sean M. West, Arthur Duplan, Raffaella Conconi, Frédéric Schütz, Pierre Gönczy, Fabio Piano, Kristin Gunsalus, Eric A. Miska, Laurent Keller

Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis

Clara Gobé, Maëva Elzaiat, Nicolas Meunier, Marjolaine André, Eli Sellem, Patrice Congar, Luc Jouneau, Aurélie Allais-Bonnet, Ikrame Naciri, Bruno Passet, Eric Pailhoux, Maëlle Pannetier

Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage

Kelvin W. Pond, Christelle de Renty, Mary K. Yagle, Nathan A. Ellis

Marine environmental DNA biomonitoring reveals seasonal patterns in biodiversity and identifies ecosystem responses to anomalous climatic events

Tina E. Berry, Benjamin J. Saunders, Megan L. Coghlan, Michael Stat, Simon Jarman, Anthony J. Richardson, Claire H. Davies, Oliver Berry, Euan S. Harvey, Michael Bunce

Fast and flexible linear mixed models for genome-wide genetics

Daniel E. Runcie, Lorin Crawford

mRNA dynamics and alternative conformations adopted under low and high arginine concentrations control polyamine biosynthesis in Salmonella

Tamar Ben-Zvi, Alina Pushkarev, Hemda Seri, Maya Elgrably-Weiss, Kai Papenfort, Shoshy Altuvia

Spatial soft sweeps: Patterns of adaptation in populations with long-range dispersal

Jayson Paulose, Joachim Hermisson, Oskar Hallatschek

Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans

Fitz Gerald S. Silao, Meliza Ward, Kicki Ryman, Axel Wallström, Björn Brindefalk, Klas Udekwu, Per O. Ljungdahl

Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila

Gabriel E. Rech, María Bogaerts-Márquez, Maite G. Barrón, Miriam Merenciano, José Luis Villanueva-Cañas, Vivien Horváth, Anna-Sophie Fiston-Lavier, Isabelle Luyten, Sandeep Venkataram, Hadi Quesneville, Dmitri A. Petrov, Josefa González

Maternal and zygotic gene regulatory effects of endogenous RNAi pathways

Miguel Vasconcelos Almeida, António Miguel de Jesus Domingues, René F. Ketting

Evolutionary rate covariation analysis of E-cadherin identifies Raskol as a regulator of cell adhesion and actin dynamics in Drosophila

Qanber Raza, Jae Young Choi, Yang Li, Roisin M. O’Dowd, Simon C. Watkins, Maria Chikina, Yang Hong, Nathan L. Clark, Adam V. Kwiatkowski

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Epigenetic inheritance of telomere length in wild birds

Christina Bauch, Jelle J. Boonekamp, Peter Korsten, Ellis Mulder, Simon Verhulst

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Spatio-temporal regulation of nuclear division by Aurora B kinase Ipl1 in Cryptococcus neoformans

Neha Varshney, Subhendu Som, Saptarshi Chatterjee, Shreyas Sridhar, Dibyendu Bhattacharyya, Raja Paul, Kaustuv Sanyal

The Wilms’ tumor suppressor gene regulates pancreas homeostasis and repair

Laura Ariza, Anabel Rojas, Ramón Muñoz-Chápuli, Rita Carmona

Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans

Nara Shin, Luciann Cuenca, Rajendiran Karthikraj, Kurunthachalam Kannan, Monica P. Colaiácovo

Sumoylation of DNA-bound transcription factor Sko1 prevents its association with nontarget promoters

Veroni S. Sri Theivakadadcham, Benjamin G. Bergey, Emanuel Rosonina

BMP signaling is required for nkx2.3-positive pharyngeal pouch progenitor specification in zebrafish

Linwei Li, Guozhu Ning, Shuyan Yang, Yifang Yan, Yu Cao, Qiang Wang

An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking

Julia Kozlitina, Davide Risso, Katherine Lansu, Reid Hans Johnson Olsen, Eduardo Sainz, Donata Luiselli, Arnab Barik, Carlos Frigerio-Domingues, Luca Pagani, Stephen Wooding, Thomas Kirchner, Ray Niaura, Bryan Roth, Dennis Drayna

Parental legacy, demography, and admixture influenced the evolution of the two subgenomes of the tetraploid Capsella bursa-pastoris (Brassicaceae)

Dmytro Kryvokhyzha, Adriana Salcedo, Mimmi C. Eriksson, Tianlin Duan, Nilesh Tawari, Jun Chen, Maria Guerrina, Julia M. Kreiner, Tyler V. Kent, Ulf Lagercrantz, John R. Stinchcombe, Sylvain Glémin, Stephen I. Wright, Martin Lascoux

Modular epistasis and the compensatory evolution of gene deletion mutants

José I. Rojas Echenique, Sergey Kryazhimskiy, Alex N. Nguyen Ba, Michael M. Desai

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease

Marah C. Runtsch, Morgan C. Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J. Villanueva, Kimberley J. Evason, Kaylyn M. Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L. Round, Micah J. Drummond, Ryan M. O’Connell

Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

Haitao Sun, Jiaxin Zhang, Siyu Xin, Meiqian Jiang, Jingjing Zhang, Zhen Li, Qinhong Cao, Huiqiang Lou

Functional lability of RNA-dependent RNA polymerases in animals

Natalia Pinzón, Stéphanie Bertrand, Lucie Subirana, Isabelle Busseau, Hector Escrivá, Hervé Seitz

Developmental regulation of DNA cytosine methylation at the immunoglobulin heavy chain constant locus

Chloé Oudinet, Fatima-Zohra Braikia, Audrey Dauba, Joana M. Santos, Ahmed Amine Khamlichi

Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans

Katleen Peymen, Jan Watteyne, Charline Borghgraef, Elien Van Sinay, Isabel Beets, Liliane Schoofs

Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration

Melissa Ducommun Priest, Maria F. Navarro, Juliane Bremer, Michael Granato

Global transcriptional regulation of innate immunity by ATF-7 in C. elegans

Marissa Fletcher, Erik J. Tillman, Vincent L. Butty, Stuart S. Levine, Dennis H. Kim

VGLL4 plays a critical role in heart valve development and homeostasis

Wei Yu, Xueyan Ma, Jinjin Xu, Andreas Wilhelm Heumüller, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang, Bin Zhou, Lei Zhang

Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway

Jingming Wang, Bryan Chan, Michael Tong, YiTing Paung, Ukhyun Jo, Dwight Martin, Markus Seeliger, John Haley, Hyungjin Kim

Reticulate evolution in eukaryotes: Origin and evolution of the nitrate assimilation pathway

Eduard Ocaña-Pallarès, Sebastián R. Najle, Claudio Scazzocchio, Iñaki Ruiz-Trillo

A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line

Bing Yang, Xia Xu, Logan Russell, Matthew T. Sullenberger, Judith L. Yanowitz, Eleanor M. Maine

Sperm-Leucylaminopeptidases are required for male fertility as structural components of mitochondrial paracrystalline material in Drosophila melanogaster sperm

Barbara Laurinyecz, Viktor Vedelek, Attila L. Kovács, Kinga Szilasi, Zoltán Lipinszki, Csilla Slezák, Zsuzsanna Darula, Gábor Juhász, Rita Sinka

The C-terminal region of Net1 is an activator of RNA polymerase I transcription with conserved features from yeast to human

Katharina Hannig, Virginia Babl, Kristin Hergert, Andreas Maier, Michael Pilsl, Christopher Schächner, Ulrike Stöckl, Philipp Milkereit, Herbert Tschochner, Wolfgang Seufert, Joachim Griesenbeck

Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes

Eva Gómez-Orte, Beatriz Sáenz-Narciso, Angelina Zheleva, Begoña Ezcurra, María de Toro, Rosario López, Irene Gastaca, Hilde Nilsen, María P. Sacristán, Ralf Schnabel, Juan Cabello

Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci

Jiafen Gong, Fan Wang, Bowei Xiao, Naim Panjwani, Fan Lin, Katherine Keenan, Julie Avolio, Mohsen Esmaeili, Lin Zhang, Gengming He, David Soave, Scott Mastromatteo, Zeynep Baskurt, Sangook Kim, Wanda K. O’Neal, Deepika Polineni, Scott M. Blackman, Harriet Corvol, Garry R. Cutting, Mitchell Drumm, Michael R. Knowles, Johanna M. Rommens, Lei Sun, Lisa J. Strug

Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish

Karen Camargo-Sosa, Sarah Colanesi, Jeanette Müller, Stefan Schulte-Merker, Derek Stemple, E. Elizabeth Patton, Robert N. Kelsh

Two isoforms of the RAC-specific guanine nucleotide exchange factor TIAM2 act oppositely on transmission ratio distortion by the mouse t-haplotype

Yves Charron, Jürgen Willert, Bettina Lipkowitz, Barica Kusecek, Bernhard G. Herrmann, Hermann Bauer

Transcription-dependent spreading of the Dal80 yeast GATA factor across the body of highly expressed genes

Aria Ronsmans, Maxime Wery, Ugo Szachnowski, Camille Gautier, Marc Descrimes, Evelyne Dubois, Antonin Morillon, Isabelle Georis

Opinion Piece

Outside in

Jonathan Flint

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