March 2015

Genetic Interaction Mapping Reveals a Role for the SWI/SNF Nucleosome Remodeler in Spliceosome Activation in Fission Yeast

Kristin L. Patrick, Colm J. Ryan, Jiewei Xu, Jesse J. Lipp, Kelly E. Nissen, Assen Roguev, Michael Shales, Nevan J. Krogan, Christine Guthrie

PLOS Genetics: published March 31, 2015 | https://doi.org/10.1371/journal.pgen.1005074

Selective and Genetic Constraints on Pneumococcal Serotype Switching

Nicholas J. Croucher, Lisa Kagedan, Claudette M. Thompson, Julian Parkhill, Stephen D. Bentley, Jonathan A. Finkelstein, Marc Lipsitch, William P. Hanage

PLOS Genetics: published March 31, 2015 | https://doi.org/10.1371/journal.pgen.1005095

Network Analyses Reveal Novel Aspects of ALS Pathogenesis

Mario Sanhueza, Andrea Chai, Colin Smith, Brett A. McCray, T. Ian Simpson, J. Paul Taylor, Giuseppa Pennetta

PLOS Genetics: published March 31, 2015 | https://doi.org/10.1371/journal.pgen.1005107

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

Olga V. Kochenova, Danielle L. Daee, Tony M. Mertz, Polina V. Shcherbakova

PLOS Genetics: published March 31, 2015 | https://doi.org/10.1371/journal.pgen.1005110

Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity

Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005071

Sex Ratio Meiotic Drive as a Plausible Evolutionary Mechanism for Hybrid Male Sterility

Linbin Zhang, Tianai Sun, Fitsum Woldesellassie, Hailian Xiao, Yun Tao

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005073

Combinatorial Control of Light Induced Chromatin Remodeling and Gene Activation in Neurospora

Cigdem Sancar, Nati Ha, Rüstem Yilmaz, Rafael Tesorero, Tamas Fisher, Michael Brunner, Gencer Sancar

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005105

A Role for the Budding Yeast Separase, Esp1, in Ty1 Element Retrotransposition

Krystina L. Ho, Lina Ma, Stephanie Cheung, Savrina Manhas, Nancy Fang, Kaiqian Wang, Barry Young, Christopher Loewen, Thibault Mayor, Vivien Measday

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005109

Arabidopsis BREVIPEDICELLUS Interacts with the SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA to Regulate KNAT2 and KNAT6 Expression in Control of Inflorescence Architecture

Minglei Zhao, Songguang Yang, Chia-Yang Chen, Chenlong Li, Wei Shan, Wangjin Lu, Yuhai Cui, Xuncheng Liu, Keqiang Wu

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005125

Unsaturation of Very-Long-Chain Ceramides Protects Plant from Hypoxia-Induced Damages by Modulating Ethylene Signaling in Arabidopsis

Li-Juan Xie, Qin-Fang Chen, Mo-Xian Chen, Lu-Jun Yu, Li Huang, Liang Chen, Feng-Zhu Wang, Fan-Nv Xia, Tian-Ren Zhu, Jian-Xin Wu, Jian Yin, Bin Liao, Jianxin Shi, Jian-Hua Zhang, Asaph Aharoni, Nan Yao, Wensheng Shu, Shi Xiao

PLOS Genetics: published March 30, 2015 | https://doi.org/10.1371/journal.pgen.1005143

Synergistic Interactions between Drosophila Orthologues of Genes Spanned by De Novo Human CNVs Support Multiple-Hit Models of Autism

Stuart J. Grice, Ji-Long Liu, Caleb Webber

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1004998

Transcriptomic Profiling of Yersinia pseudotuberculosis Reveals Reprogramming of the Crp Regulon by Temperature and Uncovers Crp as a Master Regulator of Small RNAs

Aaron M. Nuss, Ann Kathrin Heroven, Barbara Waldmann, Jan Reinkensmeier, Michael Jarek, Michael Beckstette, Petra Dersch

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005087

Mutation in MRPS34 Compromises Protein Synthesis and Causes Mitochondrial Dysfunction

Tara R. Richman, Judith A. Ermer, Stefan M. K. Davies, Kara L. Perks, Helena M. Viola, Anne-Marie J. Shearwood, Livia C. Hool, Oliver Rackham, Aleksandra Filipovska

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005089

Mitochondrial Dysfunction Reveals the Role of mRNA Poly(A) Tail Regulation in Oculopharyngeal Muscular Dystrophy Pathogenesis

Aymeric Chartier, Pierre Klein, Stéphanie Pierson, Nicolas Barbezier, Teresa Gidaro, François Casas, Steven Carberry, Paul Dowling, Laurie Maynadier, Maëlle Bellec, Martine Oloko, Claude Jardel, Bodo Moritz, George Dickson, Vincent Mouly, Kay Ohlendieck, Gillian Butler-Browne, Capucine Trollet, Martine Simonelig

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005092

The GATA Factor elt-1 Regulates C. elegans Developmental Timing by Promoting Expression of the let-7 Family MicroRNAs

Max L. Cohen, Sunhong Kim, Kiyokazu Morita, Seong Heon Kim, Min Han

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005099

GAGA Factor Maintains Nucleosome-Free Regions and Has a Role in RNA Polymerase II Recruitment to Promoters

Nicholas J. Fuda, Michael J. Guertin, Sumeet Sharma, Charles G. Danko, André L. Martins, Adam Siepel, John T. Lis

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005108

Ccr4-Not Regulates RNA Polymerase I Transcription and Couples Nutrient Signaling to the Control of Ribosomal RNA Biogenesis

R. Nicholas Laribee, Amira Hosni-Ahmed, Jason J. Workman, Hongfeng Chen

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005113

Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis

Nieves Ayllón, Margarita Villar, Ruth C. Galindo, Katherine M. Kocan, Radek Šíma, Juan A. López, Jesús Vázquez, Pilar Alberdi, Alejandro Cabezas-Cruz, Petr Kopáček, José de la Fuente

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005120

HOMER2, a Stereociliary Scaffolding Protein, Is Essential for Normal Hearing in Humans and Mice

Hela Azaiez, Amanda R. Decker, Kevin T. Booth, Allen C. Simpson, A. Eliot Shearer, Patrick L. M. Huygen, Fengxiao Bu, Michael S. Hildebrand, Paul T. Ranum, Seiji B. Shibata, Ann Turner, Yuzhou Zhang, William J. Kimberling, Robert A. Cornell, Richard J. H. Smith

PLOS Genetics: published March 27, 2015 | https://doi.org/10.1371/journal.pgen.1005137

A Genomic Portrait of Haplotype Diversity and Signatures of Selection in Indigenous Southern African Populations

Emile R. Chimusa, Ayton Meintjies, Milaine Tchanga, Nicola Mulder, Cathal Seoighe, Himla Soodyall, Rajkumar Ramesar

PLOS Genetics: published March 26, 2015 | https://doi.org/10.1371/journal.pgen.1005052

Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

Liang Ye, Leslie R. Morse, Li Zhang, Hajime Sasaki, Jason C. Mills, Paul R. Odgren, Greg Sibbel, James R. L. Stanley, Gee Wong, Ariane Zamarioli, Ricardo A. Battaglino

PLOS Genetics: published March 26, 2015 | https://doi.org/10.1371/journal.pgen.1005057

A RecA Protein Surface Required for Activation of DNA Polymerase V

Angela J. Gruber, Aysen L. Erdem, Grzegorz Sabat, Kiyonobu Karata, Malgorzata M. Jaszczur, Dan D. Vo, Tayla M. Olsen, Roger Woodgate, Myron F. Goodman, Michael M. Cox

PLOS Genetics: published March 26, 2015 | https://doi.org/10.1371/journal.pgen.1005066

Tertiary siRNAs Mediate Paramutation in C. elegans

Alexandra Sapetschnig, Peter Sarkies, Nicolas J. Lehrbach, Eric A. Miska

PLOS Genetics: published March 26, 2015 | https://doi.org/10.1371/journal.pgen.1005078

NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

Kristina Ludigs, Queralt Seguín-Estévez, Sylvain Lemeille, Isabel Ferrero, Giorgia Rota, Sonia Chelbi, Chantal Mattmann, H. Robson MacDonald, Walter Reith, Greta Guarda

PLOS Genetics: published March 26, 2015 | https://doi.org/10.1371/journal.pgen.1005088

Dual-Specificity Anti-sigma Factor Reinforces Control of Cell-Type Specific Gene Expression in Bacillus subtilis

Mónica Serrano, JinXin Gao, João Bota, Ashley R. Bate, Jeffrey Meisner, Patrick Eichenberger, Charles P. Moran Jr., Adriano O. Henriques

PLOS Genetics: published April 2, 2015 | https://doi.org/10.1371/journal.pgen.1005104

Glycosyl Phosphatidylinositol Anchor Biosynthesis Is Essential for Maintaining Epithelial Integrity during Caenorhabditis elegans Embryogenesis

Yemima Budirahardja, Thang Dinh Doan, Ronen Zaidel-Bar

PLOS Genetics: published March 25, 2015 | https://doi.org/10.1371/journal.pgen.1005082

Mutations of Human NARS2, Encoding the Mitochondrial Asparaginyl-tRNA Synthetase, Cause Nonsyndromic Deafness and Leigh Syndrome

Mariella Simon, Elodie M. Richard, Xinjian Wang, Mohsin Shahzad, Vincent H. Huang, Tanveer A. Qaiser, Prasanth Potluri, Sarah E. Mahl, Antonio Davila, Sabiha Nazli, Saege Hancock, Margret Yu, Jay Gargus, Richard Chang, Nada Al-sheqaih, William G. Newman, Jose Abdenur, Arnold Starr, Rashmi Hegde, Thomas Dorn, Anke Busch, Eddie Park, Jie Wu, Hagen Schwenzer, Adrian Flierl, Catherine Florentz, Marie Sissler, Shaheen N. Khan, Ronghua Li, Min-Xin Guan, Thomas B. Friedman, Doris K. Wu, Vincent Procaccio, Sheikh Riazuddin, Douglas C. Wallace, Zubair M. Ahmed, Taosheng Huang, Saima Riazuddin

PLOS Genetics: published March 25, 2015 | https://doi.org/10.1371/journal.pgen.1005097

A Cascade of Iron-Containing Proteins Governs the Genetic Iron Starvation Response to Promote Iron Uptake and Inhibit Iron Storage in Fission Yeast

Javier Encinar del Dedo, Natalia Gabrielli, Mercè Carmona, José Ayté, Elena Hidalgo

PLOS Genetics: published March 25, 2015 | https://doi.org/10.1371/journal.pgen.1005106

Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

Véronique Brault, Arnaud Duchon, Caroline Romestaing, Ignasi Sahun, Stéphanie Pothion, Mona Karout, Christelle Borel, Doulaye Dembele, Jean-Charles Bizot, Nadia Messaddeq, Andrew J. Sharp, Damien Roussel, Stylianos E Antonarakis, Mara Dierssen, Yann Hérault

PLOS Genetics: published March 24, 2015 | https://doi.org/10.1371/journal.pgen.1005062

Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics

Diana Raju, Sophie Schonauer, Hussein Hamzeh, Kevin C. Flynn, Frank Bradke, Katharina vom Dorp, Peter Dörmann, Yildiz Yildiz, Christian Trötschel, Ansgar Poetsch, Bernadette Breiden, Konrad Sandhoff, Heinz G. Körschen, Dagmar Wachten

PLOS Genetics: published March 24, 2015 | https://doi.org/10.1371/journal.pgen.1005063

Genome-Wide Association Studies in Dogs and Humans Identify ADAMTS20 as a Risk Variant for Cleft Lip and Palate

Zena T. Wolf, Harrison A. Brand, John R. Shaffer, Elizabeth J. Leslie, Boaz Arzi, Cali E. Willet, Timothy C. Cox, Toby McHenry, Nicole Narayan, Eleanor Feingold, Xioajing Wang, Saundra Sliskovic, Nili Karmi, Noa Safra, Carla Sanchez, Frederic W. B. Deleyiannis, Jeffrey C. Murray, Claire M. Wade, Mary L. Marazita, Danika L. Bannasch

PLOS Genetics: published March 23, 2015 | https://doi.org/10.1371/journal.pgen.1005059

The Fun30 Chromatin Remodeler Fft3 Controls Nuclear Organization and Chromatin Structure of Insulators and Subtelomeres in Fission Yeast

Babett Steglich, Annelie Strålfors, Olga Khorosjutina, Jenna Persson, Agata Smialowska, Jean-Paul Javerzat, Karl Ekwall

PLOS Genetics: published March 23, 2015 | https://doi.org/10.1371/journal.pgen.1005101

Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs

Katherine J. Siddle, Ludovic Tailleux, Matthieu Deschamps, Yong-Hwee Eddie Loh, Cécile Deluen, Brigitte Gicquel, Christophe Antoniewski, Luis B. Barreiro, Laurent Farinelli, Lluís Quintana-Murci

PLOS Genetics: published March 20, 2015 | https://doi.org/10.1371/journal.pgen.1005064

Neurospora Importin α Is Required for Normal Heterochromatic Formation and DNA Methylation

Andrew D. Klocko, Michael R. Rountree, Paula L. Grisafi, Shan M. Hays, Keyur K. Adhvaryu, Eric U. Selker

PLOS Genetics: published March 20, 2015 | https://doi.org/10.1371/journal.pgen.1005083

Zinc Finger Independent Genome-Wide Binding of Sp2 Potentiates Recruitment of Histone-Fold Protein Nf-y Distinguishing It from Sp1 and Sp3

Sara Völkel, Bastian Stielow, Florian Finkernagel, Thorsten Stiewe, Andrea Nist, Guntram Suske

PLOS Genetics: published March 20, 2015 | https://doi.org/10.1371/journal.pgen.1005102

A Genomic Duplication is Associated with Ectopic Eomesodermin Expression in the Embryonic Chicken Comb and Two Duplex-comb Phenotypes

Ben Dorshorst, Mohammad Harun-Or-Rashid, Alireza Jian Bagherpoor, Carl-Johan Rubin, Chris Ashwell, David Gourichon, Michèle Tixier-Boichard, Finn Hallböök, Leif Andersson

PLOS Genetics: published March 19, 2015 | https://doi.org/10.1371/journal.pgen.1004947

Small Regulatory RNA-Induced Growth Rate Heterogeneity of Bacillus subtilis

Ruben A. T. Mars, Pierre Nicolas, Mariano Ciccolini, Ewoud Reilman, Alexander Reder, Marc Schaffer, Ulrike Mäder, Uwe Völker, Jan Maarten van Dijl, Emma L. Denham

PLOS Genetics: published March 19, 2015 | https://doi.org/10.1371/journal.pgen.1005046

Phenotype Specific Analyses Reveal Distinct Regulatory Mechanism for Chronically Activated p53

Kristina Kirschner, Shamith A. Samarajiwa, Jonathan M. Cairns, Suraj Menon, Pedro A. Pérez-Mancera, Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott K. Lyons, Andy G. Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita

PLOS Genetics: published March 19, 2015 | https://doi.org/10.1371/journal.pgen.1005053

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

Tianxiao Huan, Tõnu Esko, Marjolein J. Peters, Luke C. Pilling, Katharina Schramm, Claudia Schurmann, Brian H. Chen, Chunyu Liu, Roby Joehanes, Andrew D. Johnson, Chen Yao, Sai-xia Ying, Paul Courchesne, Lili Milani, Nalini Raghavachari, Richard Wang, Poching Liu, Eva Reinmaa, Abbas Dehghan, Albert Hofman, André G. Uitterlinden, Dena G. Hernandez, Stefania Bandinelli, Andrew Singleton, David Melzer, Andres Metspalu, Maren Carstensen, Harald Grallert, Christian Herder, Thomas Meitinger, Annette Peters, Michael Roden, Melanie Waldenberger, Marcus Dörr, Stephan B. Felix, Tanja Zeller, International Consortium for Blood Pressure GWAS (ICBP), Ramachandran Vasan, Christopher J. O'Donnell, Peter J. Munson, Xia Yang, Holger Prokisch, Uwe Völker, Joyce B. J. van Meurs, Luigi Ferrucci, Daniel Levy

PLOS Genetics: published March 18, 2015 | https://doi.org/10.1371/journal.pgen.1005035

Escape from X Inactivation Varies in Mouse Tissues

Joel B. Berletch, Wenxiu Ma, Fan Yang, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng

PLOS Genetics: published March 18, 2015 | https://doi.org/10.1371/journal.pgen.1005079

Male-Biased Aganglionic Megacolon in the TashT Mouse Line Due to Perturbation of Silencer Elements in a Large Gene Desert of Chromosome 10

Karl-F. Bergeron, Tatiana Cardinal, Aboubacrine M. Touré, Mélanie Béland, Diana L. Raiwet, David W. Silversides, Nicolas Pilon

PLOS Genetics: published March 18, 2015 | https://doi.org/10.1371/journal.pgen.1005093

Examining the Evolution of the Regulatory Circuit Controlling Secondary Metabolism and Development in the Fungal Genus Aspergillus

Abigail L. Lind, Jennifer H. Wisecaver, Timothy D. Smith, Xuehuan Feng, Ana M. Calvo, Antonis Rokas

PLOS Genetics: published March 18, 2015 | https://doi.org/10.1371/journal.pgen.1005096

Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

Pía Villanueva, Ron Nudel, Alexander Hoischen, María Angélica Fernández, Nuala H. Simpson, Christian Gilissen, Rose H. Reader, Lillian Jara, Maria Magdalena Echeverry, Clyde Francks, Gillian Baird, Gina Conti-Ramsden, Anne O’Hare, Patrick F. Bolton, Elizabeth R. Hennessy, the SLI Consortium, Hernán Palomino, Luis Carvajal-Carmona, Joris A. Veltman, Jean-Baptiste Cazier, Zulema De Barbieri, Simon E. Fisher, Dianne F. Newbury

PLOS Genetics: published March 17, 2015 | https://doi.org/10.1371/journal.pgen.1004925

Gene Networks Underlying Convergent and Pleiotropic Phenotypes in a Large and Systematically-Phenotyped Cohort with Heterogeneous Developmental Disorders

Tallulah Andrews, Stephen Meader, Anneke Vulto-van Silfhout, Avigail Taylor, Julia Steinberg, Jayne Hehir-Kwa, Rolph Pfundt, Nicole de Leeuw, Bert B. A. de Vries, Caleb Webber

PLOS Genetics: published March 17, 2015 | https://doi.org/10.1371/journal.pgen.1005012

Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling

Husniye Kantarci, Renee K. Edlund, Andrew K. Groves, Bruce B. Riley

PLOS Genetics: published March 17, 2015 | https://doi.org/10.1371/journal.pgen.1005037

LRGUK-1 Is Required for Basal Body and Manchette Function during Spermatogenesis and Male Fertility

Yan Liu, Kathleen DeBoer, David M. de Kretser, Liza O’Donnell, Anne E. O’Connor, D. Jo Merriner, Hidenobu Okuda, Belinda Whittle, David A. Jans, Athina Efthymiadis, Robert I. McLachlan, Christopher J. Ormandy, Chris C. Goodnow, Duangporn Jamsai, Moira K. O’Bryan

PLOS Genetics: published March 17, 2015 | https://doi.org/10.1371/journal.pgen.1005090

The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese

Julia E. Martin, Lauren S. Waters, Gisela Storz, James A. Imlay

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1004977

Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer’s Model

Yong Ping, Eu-Teum Hahm, Girma Waro, Qian Song, Dai-An Vo-Ba, Ashley Licursi, Han Bao, Logan Ganoe, Kelly Finch, Susan Tsunoda

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1005025

The Nuclear Receptor DAF-12 Regulates Nutrient Metabolism and Reproductive Growth in Nematodes

Zhu Wang, Jonathan Stoltzfus, Young-jai You, Najju Ranjit, Hao Tang, Yang Xie, James B. Lok, David J. Mangelsdorf, Steven A. Kliewer

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1005027

Methyl Farnesoate Plays a Dual Role in Regulating Drosophila Metamorphosis

Di Wen, Crisalejandra Rivera-Perez, Mohamed Abdou, Qiangqiang Jia, Qianyu He, Xi Liu, Ola Zyaan, Jingjing Xu, William G. Bendena, Stephen S. Tobe, Fernando G. Noriega, Subba R. Palli, Jian Wang, Sheng Li

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1005038

Nab3 Facilitates the Function of the TRAMP Complex in RNA Processing via Recruitment of Rrp6 Independent of Nrd1

Milo B. Fasken, R. Nicholas Laribee, Anita H. Corbett

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1005044

Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites

Jacob A. Tennessen, André Théron, Melanie Marine, Jan-Ying Yeh, Anne Rognon, Michael S. Blouin

PLOS Genetics: published March 16, 2015 | https://doi.org/10.1371/journal.pgen.1005067

The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

Sarai Pacheco, Marina Marcet-Ortega, Julian Lange, Maria Jasin, Scott Keeney, Ignasi Roig

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005017

A Zinc Finger Motif-Containing Protein Is Essential for Chloroplast RNA Editing

Tao Sun, Xiaowen Shi, Giulia Friso, Klaas Van Wijk, Stephane Bentolila, Maureen R. Hanson

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005028

NatB Domain-Containing CRA-1 Antagonizes Hydrolase ACER-1 Linking Acetyl-CoA Metabolism to the Initiation of Recombination during C. elegans Meiosis

Jinmin Gao, Hyun-Min Kim, Andrew E. Elia, Stephen J. Elledge, Monica P. Colaiácovo

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005029

Reproductive Isolation of Hybrid Populations Driven by Genetic Incompatibilities

Molly Schumer, Rongfeng Cui, Gil G. Rosenthal, Peter Andolfatto

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005041

The Role of China in the Global Spread of the Current Cholera Pandemic

Xavier Didelot, Bo Pang, Zhemin Zhou, Angela McCann, Peixiang Ni, Dongfang Li, Mark Achtman, Biao Kan

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005072

Clonality and Evolutionary History of Rhabdomyosarcoma

Li Chen, Jack F. Shern, Jun S. Wei, Marielle E. Yohe, Young K. Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X. Skapek, Frederic G. Barr, Douglas S. Hawkins, Javed Khan

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005075

RECG Maintains Plastid and Mitochondrial Genome Stability by Suppressing Extensive Recombination between Short Dispersed Repeats

Masaki Odahara, Yuichi Masuda, Mayuko Sato, Mayumi Wakazaki, Chizuru Harada, Kiminori Toyooka, Yasuhiko Sekine

PLOS Genetics: published March 13, 2015 | https://doi.org/10.1371/journal.pgen.1005080

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

Lily Paemka, Vinit B. Mahajan, Salleh N. Ehaideb, Jessica M. Skeie, Men Chee Tan, Shu Wu, Allison J. Cox, Levi P. Sowers, Jozef Gecz, Lachlan Jolly, Polly J. Ferguson, Benjamin Darbro, Amy Schneider, Ingrid E. Scheffer, Gemma L. Carvill, Heather C. Mefford, Hatem El-Shanti, Stephen A. Wood, J. Robert Manak, Alexander G. Bassuk

PLOS Genetics: published March 12, 2015 | https://doi.org/10.1371/journal.pgen.1005022

Genome-wide Association Study and Meta-Analysis Identify ISL1 as Genome-wide Significant Susceptibility Gene for Bladder Exstrophy

Markus Draaken, Michael Knapp, Tracie Pennimpede, Johanna M. Schmidt, Anne-Karolin Ebert, Wolfgang Rösch, Raimund Stein, Boris Utsch, Karin Hirsch, Thomas M. Boemers, Elisabeth Mangold, Stefanie Heilmann, Kerstin U. Ludwig, Ekkehart Jenetzky, Nadine Zwink, Susanne Moebus, Bernhard G. Herrmann, Manuel Mattheisen, Markus M. Nöthen, Michael Ludwig, Heiko Reutter

PLOS Genetics: published March 12, 2015 | https://doi.org/10.1371/journal.pgen.1005024

The Complex Contributions of Genetics and Nutrition to Immunity in Drosophila melanogaster

Robert L. Unckless, Susan M. Rottschaefer, Brian P. Lazzaro

PLOS Genetics: published March 12, 2015 | https://doi.org/10.1371/journal.pgen.1005030

Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis

Jacqueline M. Benson, Jesse A. Poland, Brent M. Benson, Erik L. Stromberg, Rebecca J. Nelson

PLOS Genetics: published March 12, 2015 | https://doi.org/10.1371/journal.pgen.1005045

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair

Maria E. Morales, Travis B. White, Vincent A. Streva, Cecily B. DeFreece, Dale J. Hedges, Prescott L. Deininger

PLOS Genetics: published March 11, 2015 | https://doi.org/10.1371/journal.pgen.1005016

Effects on Murine Behavior and Lifespan of Selectively Decreasing Expression of Mutant Huntingtin Allele by Supt4h Knockdown

Hui-Min Cheng, Yijuang Chern, I-Hui Chen, Chia-Rung Liu, Sih-Huei Li, Seung J. Chun, Frank Rigo, C. Frank Bennett, Ning Deng, Yanan Feng, Chyuan-Sheng Lin, Yu-Ting Yan, Stanley N. Cohen, Tzu-Hao Cheng

PLOS Genetics: published March 11, 2015 | https://doi.org/10.1371/journal.pgen.1005043

Cis-Regulatory Mechanisms for Robust Olfactory Sensory Neuron Class-restricted Odorant Receptor Gene Expression in Drosophila

Shadi Jafari, Mattias Alenius

PLOS Genetics: published March 11, 2015 | https://doi.org/10.1371/journal.pgen.1005051

The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in Xenopus

John N. Griffin, Samuel B. Sondalle, Florencia del Viso, Susan J. Baserga, Mustafa K. Khokha

PLOS Genetics: published March 10, 2015 | https://doi.org/10.1371/journal.pgen.1005018

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Linya You, Kezhi Yan, Jinfeng Zhou, Hong Zhao, Nicholas R. Bertos, Morag Park, Edwin Wang, Xiang-Jiao Yang

PLOS Genetics: published March 10, 2015 | https://doi.org/10.1371/journal.pgen.1005034

Maternal Co-ordinate Gene Regulation and Axis Polarity in the Scuttle Fly Megaselia abdita

Karl R. Wotton, Eva Jiménez-Guri, Johannes Jaeger

PLOS Genetics: published March 10, 2015 | https://doi.org/10.1371/journal.pgen.1005042

Maternal Filaggrin Mutations Increase the Risk of Atopic Dermatitis in Children: An Effect Independent of Mutation Inheritance

Jorge Esparza-Gordillo, Anja Matanovic, Ingo Marenholz, Anja Bauerfeind, Klaus Rohde, Katja Nemat, Min-Ae Lee-Kirsch, Magnus Nordenskjöld, Marten C. G. Winge, Thomas Keil, Renate Krüger, Susanne Lau, Kirsten Beyer, Birgit Kalb, Bodo Niggemann, Norbert Hübner, Heather J. Cordell, Maria Bradley, Young-Ae Lee

PLOS Genetics: published March 10, 2015 | https://doi.org/10.1371/journal.pgen.1005076

Drosophila S6 Kinase Like Inhibits Neuromuscular Junction Growth by Downregulating the BMP Receptor Thickveins

Guoli Zhao, Yingga Wu, Li Du, Wenhua Li, Ying Xiong, Aiyu Yao, Qifu Wang, Yong Q. Zhang

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1004984

Pervasive Variation of Transcription Factor Orthologs Contributes to Regulatory Network Evolution

Shilpa Nadimpalli, Anton V. Persikov, Mona Singh

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1005011

HDAC4-Myogenin Axis As an Important Marker of HD-Related Skeletal Muscle Atrophy

Michal Mielcarek, Marta Toczek, Cleo J. L. M. Smeets, Sophie A. Franklin, Marie K. Bondulich, Nelly Jolinon, Thomas Muller, Mhoriam Ahmed, James R. T. Dick, Izabela Piotrowska, Linda Greensmith, Ryszard T. Smolenski, Gillian P. Bates

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1005021

A Conserved Domain in the Scc3 Subunit of Cohesin Mediates the Interaction with Both Mcd1 and the Cohesin Loader Complex

Ola Orgil, Avi Matityahu, Thomas Eng, Vincent Guacci, Douglas Koshland, Itay Onn

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1005036

Complex Genomic Rearrangements at the PLP1 Locus Include Triplication and Quadruplication

Christine R. Beck, Claudia M. B. Carvalho, Linda Banser, Tomasz Gambin, Danielle Stubbolo, Bo Yuan, Karen Sperle, Suzanne M. McCahan, Marco Henneke, Pavel Seeman, James Y. Garbern, Grace M. Hobson, James R. Lupski

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1005050

A Systems-Level Interrogation Identifies Regulators of Drosophila Blood Cell Number and Survival

Richelle Sopko, You Bin Lin, Kalpana Makhijani, Brandy Alexander, Norbert Perrimon, Katja Brückner

PLOS Genetics: published March 6, 2015 | https://doi.org/10.1371/journal.pgen.1005056

Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

Carrie L. Flood, Gina P. Rodriguez, Gaobin Bao, Arthur H. Shockley, Yoke Wah Kow, Gray F. Crouse

PLOS Genetics: published March 5, 2015 | https://doi.org/10.1371/journal.pgen.1005049

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

Sandra Catania, Alison L. Pidoux, Robin C. Allshire

PLOS Genetics: published March 4, 2015 | https://doi.org/10.1371/journal.pgen.1004986

The Bicoid Class Homeodomain Factors ceh-36/OTX and unc-30/PITX Cooperate in C. elegans Embryonic Progenitor Cells to Regulate Robust Development

Travis Walton, Elicia Preston, Gautham Nair, Amanda L. Zacharias, Arjun Raj, John Isaac Murray

PLOS Genetics: published March 4, 2015 | https://doi.org/10.1371/journal.pgen.1005003

Rapid Evolution of Recombinant Saccharomyces cerevisiae for Xylose Fermentation through Formation of Extra-chromosomal Circular DNA

Mekonnen M. Demeke, María R. Foulquié-Moreno, Françoise Dumortier, Johan M. Thevelein

PLOS Genetics: published March 4, 2015 | https://doi.org/10.1371/journal.pgen.1005010

Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling

Yueh-Chiang Hu, Peter K. Nicholls, Y. Q. Shirleen Soh, Joseph R. Daniele, Jan Philipp Junker, Alexander van Oudenaarden, David C. Page

PLOS Genetics: published March 4, 2015 | https://doi.org/10.1371/journal.pgen.1005019

Recombination between Homologous Chromosomes Induced by Unrepaired UV-Generated DNA Damage Requires Mus81p and Is Suppressed by Mms2p

Yi Yin, Thomas D. Petes

PLOS Genetics: published March 4, 2015 | https://doi.org/10.1371/journal.pgen.1005026

PHABULOSA Controls the Quiescent Center-Independent Root Meristem Activities in Arabidopsis thaliana

Jose Sebastian, Kook Hui Ryu, Jing Zhou, Danuše Tarkowská, Petr Tarkowski, Young-Hee Cho, Sang-Dong Yoo, Eun-Sol Kim, Ji-Young Lee

PLOS Genetics: published March 2, 2015 | https://doi.org/10.1371/journal.pgen.1004973

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Transcription factors control comb development in chickens.

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