February 2014

X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids

Tanmoy Bhattacharyya, Radka Reifova, Sona Gregorova, Petr Simecek, Vaclav Gergelits, Martin Mistrik, Iva Martincova, Jaroslav Pialek, Jiri Forejt

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004088

Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24

Caryline Agler, Dahlia M. Nielsen, Ganokon Urkasemsin, Andrew Singleton, Noriko Tonomura, Snaevar Sigurdsson, Ruqi Tang, Keith Linder, Sampath Arepalli, Dena Hernandez, Kerstin Lindblad-Toh, Joyce van de Leemput, Alison Motsinger-Reif, Dennis P. O'Brien, Jerold Bell, Tonya Harris, Steven Steinberg, Natasha J. Olby

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1003991

Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging

Mario G. Mirisola, Giusi Taormina, Paola Fabrizio, Min Wei, Jia Hu, Valter D. Longo

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004113

Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive

Linda Odenthal-Hesse, Ingrid L. Berg, Amelia Veselis, Alec J. Jeffreys, Celia A. May

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004106

The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted to Fluctuating Environments

Feifei Xu, Jon Jerlström-Hultqvist, Elin Einarsson, Ásgeir Ástvaldsson, Staffan G. Svärd, Jan O. Andersson

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004053

The Streamlined Genome of Phytomonas spp. Relative to Human Pathogenic Kinetoplastids Reveals a Parasite Tailored for Plants

Betina M. Porcel, France Denoeud, Fred Opperdoes, Benjamin Noel, Mohammed-Amine Madoui, Tansy C. Hammarton, Mark C. Field, Corinne Da Silva, Arnaud Couloux, Julie Poulain, Michael Katinka, Kamel Jabbari, Jean-Marc Aury, David A. Campbell, Roxana Cintron, Nicholas J. Dickens, Roberto Docampo, Nancy R. Sturm, V. Lila Koumandou, Sandrine Fabre, Pavel Flegontov, Julius Lukeš, Shulamit Michaeli, Jeremy C. Mottram, Balázs Szöőr, Dan Zilberstein, Frédéric Bringaud, Patrick Wincker, Michel Dollet

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004007

Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in C. elegans and Drosophila

Chandan Bhambhani, Aditi J. Ravindranath, Remco A. Mentink, Mikyung V. Chang, Marco C. Betist, Yaxuan X. Yang, Sandhya P. Koushika, Hendrik C. Korswagen, Ken M. Cadigan

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004133

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

Taru Tukiainen, Matti Pirinen, Antti-Pekka Sarin, Claes Ladenvall, Johannes Kettunen, Terho Lehtimäki, Marja-Liisa Lokki, Markus Perola, Juha Sinisalo, Efthymia Vlachopoulou, Johan G. Eriksson, Leif Groop, Antti Jula, Marjo-Riitta Järvelin, Olli T. Raitakari, Veikko Salomaa, Samuli Ripatti

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004127

Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association

Konrad J. Karczewski, Michael Snyder, Russ B. Altman, Nicholas P. Tatonetti

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004122

Sex-Specific Embryonic Gene Expression in Species with Newly Evolved Sex Chromosomes

Susan E. Lott, Jacqueline E. Villalta, Qi Zhou, Doris Bachtrog, Michael B. Eisen

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004159

Comparative RNAi Screens in C. elegans and C. briggsae Reveal the Impact of Developmental System Drift on Gene Function

Adrian J. Verster, Arun K. Ramani, Sheldon J. McKay, Andrew G. Fraser

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004077

Euchromatic Transposon Insertions Trigger Production of Novel Pi- and Endo-siRNAs at the Target Sites in the Drosophila Germline

Sergey Shpiz, Sergei Ryazansky, Ivan Olovnikov, Yuri Abramov, Alla Kalmykova

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004138

NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly

Metodi Dimitrov Metodiev, Henrik Spåhr, Paola Loguercio Polosa, Caroline Meharg, Christian Becker, Janine Altmueller, Bianca Habermann, Nils-Göran Larsson, Benedetta Ruzzenente

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004110

DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegans

Jennifer M. A. Tullet, Caroline Araiz, Matthew J. Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily Clark, Kathrin Schmeisser, Daniel Jones, Eugene F. Schuster, Janet M. Thornton, David Gems

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004109

DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes

Dimos Gaidatzis, Lukas Burger, Rabih Murr, Anita Lerch, Sophie Dessus-Babus, Dirk Schübeler, Michael B. Stadler

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004143

Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons

Zhe Zhang, Chan-Juan Hao, Chang-Gui Li, Dong-Jie Zang, Jing Zhao, Xiao-Nan Li, Ai-Hua Wei, Zong-Bo Wei, Lin Yang, Xin He, Xue-Chu Zhen, Xiang Gao, John R. Speakman, Wei Li

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004124

Molecular Identification of Collagen 17a1 as a Major Genetic Modifier of Laminin Gamma 2 Mutation-Induced Junctional Epidermolysis Bullosa in Mice

Thomas J. Sproule, Jason A. Bubier, Fiorella C. Grandi, Victor Z. Sun, Vivek M. Philip, Caroline G. McPhee, Elisabeth B. Adkins, John P. Sundberg, Derry C. Roopenian

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004068

Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency

Hui Ma, Hui Min Ng, Xiuwen Teh, Hu Li, Yun Hwa Lee, Yew Mei Chong, Yuin Han Loh, James J. Collins, Bo Feng, Henry Yang, Qiang Wu

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004038

Fine-Mapping the HOXB Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer

Edward J. Saunders, Tokhir Dadaev, Daniel A. Leongamornlert, Sarah Jugurnauth-Little, Malgorzata Tymrakiewicz, Fredrik Wiklund, Ali Amin Al Olama, Sara Benlloch, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Graham G. Giles, Gianluca Severi, Henrik Gronberg, Markus Aly, Christopher A. Haiman, Fredrick Schumacher, Brian E. Henderson, Sara Lindstrom, Peter Kraft, David J. Hunter, Susan Gapstur, Stephen Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Børge G. Nordestgaard, Federico Canzian, Daniele Campa, Elio Riboli, Tim J. Key, Ruth C. Travis, Sue A. Ingles, Esther M. John, Richard B. Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L. Stanford, Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Daniel Schaid, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y. Park, Radka Kaneva, Jyotsna Batra, Judith A. Clements, Manuel R. Teixeira, Jianfeng Xu, Christos Mikropoulos, Chee Goh, Koveela Govindasami, Michelle Guy, Rosemary A. Wilkinson, Emma J. Sawyer, Angela Morgan, COGS-CRUK GWAS-ELLIPSE (Part of GAME-ON) Initiative, The UK Genetic Prostate Cancer Study Collaborators, The UK ProtecT Study Collaborators, The PRACTICAL Consortium, Douglas F. Easton, Ken Muir, Rosalind A. Eeles, Zsofia Kote-Jarai

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004129

Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations

Leslie S. Itsara, Scott R. Kennedy, Edward J. Fox, Selina Yu, Joshua J. Hewitt, Monica Sanchez-Contreras, Fernando Cardozo-Pelaez, Leo J. Pallanck

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1003974

Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor

Svetlana Gorokhova, Stéphane Gaillard, Louise Urien, Pascale Malapert, Wassim Legha, Grégory Baronian, Jean-Pierre Desvignes, Serge Alonso, Aziz Moqrich

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004081

Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning

Gad Abraham, Jason A. Tye-Din, Oneil G. Bhalala, Adam Kowalczyk, Justin Zobel, Michael Inouye

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004137

Transcriptomics and Functional Genomics of ROS-Induced Cell Death Regulation by RADICAL-INDUCED CELL DEATH1

Mikael Brosché, Tiina Blomster, Jarkko Salojärvi, Fuqiang Cui, Nina Sipari, Johanna Leppälä, Airi Lamminmäki, Gloria Tomai, Shaman Narayanasamy, Ramesha A. Reddy, Markku Keinänen, Kirk Overmyer, Jaakko Kangasjärvi

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004112

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

Mitesh J. Borad, Mia D. Champion, Jan B. Egan, Winnie S. Liang, Rafael Fonseca, Alan H. Bryce, Ann E. McCullough, Michael T. Barrett, Katherine Hunt, Maitray D. Patel, Scott W. Young, Joseph M. Collins, Alvin C. Silva, Rachel M. Condjella, Matthew Block, Robert R. McWilliams, Konstantinos N. Lazaridis, Eric W. Klee, Keith C. Bible, Pamela Harris, Gavin R. Oliver, Jaysheel D. Bhavsar, Asha A. Nair, Sumit Middha, Yan Asmann, Jean-Pierre Kocher, Kimberly Schahl, Benjamin R. Kipp, Emily G. Barr Fritcher, Angela Baker, Jessica Aldrich, Ahmet Kurdoglu, Tyler Izatt, Alexis Christoforides, Irene Cherni, Sara Nasser, Rebecca Reiman, Lori Phillips, Jackie McDonald, Jonathan Adkins, Stephen D. Mastrian, Pamela Placek, Aprill T. Watanabe, Janine LoBello, Haiyong Han, Daniel Von Hoff, David W. Craig, A. Keith Stewart, John D. Carpten

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004135

Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

Amitava Bandhu, John Kang, Kenzo Fukunaga, Greicy Goto, Katsunori Sugimoto

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004136

A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS

Jessica Zuin, Vedran Franke, Wilfred F. J. van IJcken, Antoine van der Sloot, Ian D. Krantz, Michael I. J. A. van der Reijden, Ryuichiro Nakato, Boris Lenhard, Kerstin S. Wendt

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004153

Insights into the Dekkera bruxellensis Genomic Landscape: Comparative Genomics Reveals Variations in Ploidy and Nutrient Utilisation Potential amongst Wine Isolates

Anthony R. Borneman, Ryan Zeppel, Paul J. Chambers, Chris D. Curtin

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004161

Mechanistically Distinct Mouse Models for CRX-Associated Retinopathy

Nicholas M. Tran, Alan Zhang, Xiaodong Zhang, Julie B. Huecker, Anne K. Hennig, Shiming Chen

PLOS Genetics: published February 6, 2014 | https://doi.org/10.1371/journal.pgen.1004111

A Long-Chain Flavodoxin Protects Pseudomonas aeruginosa from Oxidative Stress and Host Bacterial Clearance

Alejandro J. Moyano, Romina A. Tobares, Yanina S. Rizzi, Adriana R. Krapp, Juan A. Mondotte, José L. Bocco, Maria-Carla Saleh, Néstor Carrillo, Andrea M. Smania

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004163

The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome

Xitiz Chamling, Seongjin Seo, Charles C. Searby, GunHee Kim, Diane C. Slusarski, Val C. Sheffield

PLOS Genetics: published February 13, 2014 | https://doi.org/10.1371/journal.pgen.1004083

Arf4 Is Required for Mammalian Development but Dispensable for Ciliary Assembly

John A. Follit, Jovenal T. San Agustin, Julie A. Jonassen, Tingting Huang, Jaime A. Rivera-Perez, Kimberly D. Tremblay, Gregory J. Pazour

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004170

Loss of Trabid, a New Negative Regulator of the Drosophila Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span

Merennege Dilan Anush Fernando, Ilias Kounatidis, Petros Ligoxygakis

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004117

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

Kristina Ibáñez, César Boullosa, Rafael Tabarés-Seisdedos, Anaïs Baudot, Alfonso Valencia

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004173

Genomic Networks of Hybrid Sterility

Leslie M. Turner, Michael A. White, Diethard Tautz, Bret A. Payseur

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004162

Natural Polymorphisms in Tap2 Influence Negative Selection and CD4∶CD8 Lineage Commitment in the Rat

Jonatan Tuncel, Sabrina Haag, Anthony C. Y. Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A. Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A. Zubarev, Richard Mott, Timothy J. Aitman, Jonathan Flint, Rikard Holmdahl

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004151

Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links

Rico Rueedi, Mirko Ledda, Andrew W. Nicholls, Reza M. Salek, Pedro Marques-Vidal, Edgard Morya, Koichi Sameshima, Ivan Montoliu, Laeticia Da Silva, Sebastiano Collino, François-Pierre Martin, Serge Rezzi, Christoph Steinbeck, Dawn M. Waterworth, Gérard Waeber, Peter Vollenweider, Jacques S. Beckmann, Johannes Le Coutre, Vincent Mooser, Sven Bergmann, Ulrich K. Genick, Zoltán Kutalik

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004132

Distinct Requirements for Cranial Ectoderm and Mesenchyme-Derived Wnts in Specification and Differentiation of Osteoblast and Dermal Progenitors

L. Henry Goodnough, Gregg J. DiNuoscio, James W. Ferguson, Trevor Williams, Richard A. Lang, Radhika P. Atit

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004152

Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in Escherichia coli

Mohan Babu, Roland Arnold, Cedoljub Bundalovic-Torma, Alla Gagarinova, Keith S. Wong, Ashwani Kumar, Geordie Stewart, Bahram Samanfar, Hiroyuki Aoki, Omar Wagih, James Vlasblom, Sadhna Phanse, Krunal Lad, Angela Yeou Hsiung Yu, Christopher Graham, Ke Jin, Eric Brown, Ashkan Golshani, Philip Kim, Gabriel Moreno-Hagelsieb, Jack Greenblatt, Walid A. Houry, John Parkinson, Andrew Emili

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004120

Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa

Johannes Engelken, Elena Carnero-Montoro, Marc Pybus, Glen K. Andrews, Carles Lalueza-Fox, David Comas, Israel Sekler, Marco de la Rasilla, Antonio Rosas, Mark Stoneking, Miguel A. Valverde, Rubén Vicente, Elena Bosch

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004128

Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Drosophila Male Germline

Simon W. A. Titen, Ho-Chen Lin, Jayaram Bhandari, Kent G. Golic

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004130

Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response

Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S. Buchholz, Ao Liu, Kunfu Ouyang, Matthew J. Stroud, Larry Gerace, Sylvia M. Evans, Andrew McCulloch, Ju Chen

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004114

Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and Function

Jana Link, Monika Leubner, Johannes Schmitt, Eva Göb, Ricardo Benavente, Kuan-Teh Jeang, Rener Xu, Manfred Alsheimer

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004099

Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1

Xuefang Pan, Lubov Grigoryeva, Volkan Seyrantepe, Junzheng Peng, Katrin Kollmann, Johanne Tremblay, Julie L. Lavoie, Aleksander Hinek, Torben Lübke, Alexey V. Pshezhetsky

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004146

Negative Feedback and Transcriptional Overshooting in a Regulatory Network for Horizontal Gene Transfer

Raul Fernandez-Lopez, Irene del Campo, Carlos Revilla, Ana Cuevas, Fernando de la Cruz

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004171

The Caenorhabditis elegans Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9

Ignacio Perez de la Cruz, Long Ma, H. Robert Horvitz

PLOS Genetics: published February 20, 2014 | https://doi.org/10.1371/journal.pgen.1004175

Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

Hsin-Hung Chou, Nigel F. Delaney, Jeremy A. Draghi, Christopher J. Marx

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004149

A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology

Erik C. Andersen, Joshua S. Bloom, Justin P. Gerke, Leonid Kruglyak

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004156

Chromosome I Controls Chromosome II Replication in Vibrio cholerae

Jong Hwan Baek, Dhruba K. Chattoraj

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004184

DAAM Is Required for Thin Filament Formation and Sarcomerogenesis during Muscle Development in Drosophila

Imre Molnár, Ede Migh, Szilárd Szikora, Tibor Kalmár, Attila G. Végh, Ferenc Deák, Szilvia Barkó, Beáta Bugyi, Zacharias Orfanos, János Kovács, Gábor Juhász, György Váró, Miklós Nyitrai, John Sparrow, József Mihály

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004166

Classic Selective Sweeps Revealed by Massive Sequencing in Cattle

Saber Qanbari, Hubert Pausch, Sandra Jansen, Mehmet Somel, Tim M. Strom, Ruedi Fries, Rasmus Nielsen, Henner Simianer

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004148

High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions

Erika Garay, Sergio E. Campos, Jorge González de la Cruz, Ana P. Gaspar, Adrian Jinich, Alexander DeLuna

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004168

Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication

Soumini Vasan, Angela Deem, Sreejith Ramakrishnan, Juan Lucas Argueso, Anna Malkova

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004119

Within-Host Spatiotemporal Dynamics of Plant Virus Infection at the Cellular Level

Nicolas Tromas, Mark P. Zwart, Guillaume Lafforgue, Santiago F. Elena

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004186

Selective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes

Ahmed Z. Balboula, Karen Schindler

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004194

MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis

Andrew G. Hoss, Vinay K. Kartha, Xianjun Dong, Jeanne C. Latourelle, Alexandra Dumitriu, Tiffany C. Hadzi, Marcy E. MacDonald, James F. Gusella, Schahram Akbarian, Jiang-Fan Chen, Zhiping Weng, Richard H. Myers

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004188

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Camille A. Huser, Kathryn L. Gilroy, Jeroen de Ridder, Anna Kilbey, Gillian Borland, Nancy Mackay, Alma Jenkins, Margaret Bell, Pawel Herzyk, Louise van der Weyden, David J. Adams, Alistair G. Rust, Ewan Cameron, James C. Neil

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004167

Convergence of Light and ABA Signaling on the ABI5 Promoter

Dongqing Xu, Jigang Li, Sreeramaiah N. Gangappa, Chamari Hettiarachchi, Fang Lin, Mats X. Andersson, Yan Jiang, Xing Wang Deng, Magnus Holm

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004197

Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective

Matthieu Foll, Yu-Ping Poh, Nicholas Renzette, Anna Ferrer-Admetlla, Claudia Bank, Hyunjin Shim, Anna-Sapfo Malaspinas, Gregory Ewing, Ping Liu, Daniel Wegmann, Daniel R. Caffrey, Konstantin B. Zeldovich, Daniel N. Bolon, Jennifer P. Wang, Timothy F. Kowalik, Celia A. Schiffer, Robert W. Finberg, Jeffrey D. Jensen

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004185

miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion

Dahu Chen, Yutong Sun, Yuan Yuan, Zhenbo Han, Peijing Zhang, Jinsong Zhang, M. James You, Julie Teruya-Feldstein, Min Wang, Sumeet Gupta, Mien-Chie Hung, Han Liang, Li Ma

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004177

Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis

Laetitia Martinerie, Marcia Manterola, Sanny S. W. Chung, Sunil K. Panigrahi, Melissa Weisbach, Ana Vasileva, Yan Geng, Peter Sicinski, Debra J. Wolgemuth

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004165

MicroRNA-133 Inhibits Behavioral Aggregation by Controlling Dopamine Synthesis in Locusts

Meiling Yang, Yuanyuan Wei, Feng Jiang, Yanli Wang, Xiaojiao Guo, Jing He, Le Kang

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004206

Transcriptome-Wide Analyses of 5′-Ends in RNase J Mutants of a Gram-Positive Pathogen Reveal a Role in RNA Maturation, Regulation and Degradation

Patrick Linder, Sylvain Lemeille, Peter Redder

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004207

CEP-1, the Caenorhabditis elegans p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants

Aiswarya Baruah, Hsinwen Chang, Mathew Hall, Jie Yuan, Sarah Gordon, Erik Johnson, Ludmila L. Shtessel, Callista Yee, Siegfried Hekimi, W. Brent Derry, Siu Sylvia Lee

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004097

Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis

Johan L. M. Björkegren, Sara Hägg, Husain A. Talukdar, Hassan Foroughi Asl, Rajeev K. Jain, Cecilia Cedergren, Ming-Mei Shang, Aránzazu Rossignoli, Rabbe Takolander, Olle Melander, Anders Hamsten, Tom Michoel, Josefin Skogsberg

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004201

Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease

Marco Medici, Eleonora Porcu, Giorgio Pistis, Alexander Teumer, Suzanne J. Brown, Richard A. Jensen, Rajesh Rawal, Greet L. Roef, Theo S. Plantinga, Sita H. Vermeulen, Jari Lahti, Matthew J. Simmonds, Lise Lotte N. Husemoen, Rachel M. Freathy, Beverley M. Shields, Diana Pietzner, Rebecca Nagy, Linda Broer, Layal Chaker, Tim I. M. Korevaar, Maria Grazia Plia, Cinzia Sala, Uwe Völker, J. Brent Richards, Fred C. Sweep, Christian Gieger, Tanguy Corre, Eero Kajantie, Betina Thuesen, Youri E. Taes, W. Edward Visser, Andrew T. Hattersley, Jürgen Kratzsch, Alexander Hamilton, Wei Li, Georg Homuth, Monia Lobina, Stefano Mariotti, Nicole Soranzo, Massimiliano Cocca, Matthias Nauck, Christin Spielhagen, Alec Ross, Alice Arnold, Martijn van de Bunt, Sandya Liyanarachchi, Margit Heier, Hans Jörgen Grabe, Corrado Masciullo, Tessel E. Galesloot, Ee M. Lim, Eva Reischl, Peter J. Leedman, Sandra Lai, Alessandro Delitala, Alexandra P. Bremner, David I. W. Philips, John P. Beilby, Antonella Mulas, Matteo Vocale, Goncalo Abecasis, Tom Forsen, Alan James, Elisabeth Widen, Jennie Hui, Holger Prokisch, Ernst E. Rietzschel, Aarno Palotie, Peter Feddema, Stephen J. Fletcher, Katharina Schramm, Jerome I. Rotter, Alexander Kluttig, Dörte Radke, Michela Traglia, Gabriela L. Surdulescu, Huiling He, Jayne A. Franklyn, Daniel Tiller, Bijay Vaidya, Tim de Meyer, Torben Jørgensen, Johan G. Eriksson, Peter C. O'Leary, Eric Wichmann, Ad R. Hermus, Bruce M. Psaty, Till Ittermann, Albert Hofman, Emanuele Bosi, David Schlessinger, Henri Wallaschofski, Nicola Pirastu, Yurii S. Aulchenko, Albert de la Chapelle, Romana T. Netea-Maier, Stephen C. L. Gough, Henriette Meyer zu Schwabedissen, Timothy M. Frayling, Jean-Marc Kaufman, Allan Linneberg, Katri Räikkönen, Johannes W. A. Smit, Lambertus A. Kiemeney, Fernando Rivadeneira, André G. Uitterlinden, John P. Walsh, Christa Meisinger, Martin den Heijer, Theo J. Visser, Timothy D. Spector, Scott G. Wilson, Henry Völzke, Anne Cappola, Daniela Toniolo, Serena Sanna, Silvia Naitza, Robin P. Peeters

PLOS Genetics: published February 27, 2014 | https://doi.org/10.1371/journal.pgen.1004123

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Drinking from the cup of adaptive landscapes: modeling a phenotypic fitness landscape of gene expression to predict epistasis between beneficial mutations.

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