January 2014

The evolution and development of sex-specific traits in animals has long fascinated biologists. How have these traits developed and evolved? What are the genetic mechanisms underlying the diversity of sexually selected, sex-specific traits in animals? In this issue, Gotoh and colleagues present results from a study linking the sex-determination pathway with the regulation of condition-dependent mandible growth in the stag beetle Cyclommatus metallifer. Their study focuses on the conserved sex-determination gene doublesex (dsx) and its interaction with juvenile hormone, which together regulate condition-sensitive growth of sex-specific traits in the sexually dimorphic stag beetle. See Gotoh et al.

Image Credit: Hiroki Gotoh

Perspectives

Unwrapping Bacteria

Kevin D. Young

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004054

How Much Is That in Dog Years? The Advent of Canine Population Genomics

Greger Larson, Daniel G. Bradley

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004093

The Sense and Sensibility of Strand Exchange in Recombination Homeostasis

Francesca Cole

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004104

Reviews

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

Mireille Bétermier, Pascale Bertrand, Bernard S. Lopez

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004086

Single Cell Genomics: Advances and Future Perspectives

Iain C. Macaulay, Thierry Voet

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004126

Research Articles

The SPF27 Homologue Num1 Connects Splicing and Kinesin 1-Dependent Cytoplasmic Trafficking in Ustilago maydis

Nikola Kellner, Kai Heimel, Theresa Obhof, Florian Finkernagel, Jörg Kämper

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004046

Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response

Vyacheslav M. Labunskyy, Maxim V. Gerashchenko, Joe R. Delaney, Alaattin Kaya, Brian K. Kennedy, Matt Kaeberlein, Vadim N. Gladyshev

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004019

Translation Enhancing ACA Motifs and Their Silencing by a Bacterial Small Regulatory RNA

Qi Yang, Nara Figueroa-Bossi, Lionello Bossi

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004026

Subtle Changes in Motif Positioning Cause Tissue-Specific Effects on Robustness of an Enhancer's Activity

Jelena Erceg, Timothy E. Saunders, Charles Girardot, Damien P. Devos, Lars Hufnagel, Eileen E. M. Furlong

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004060

DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4⁺ T-Cell Population Structure

Colm E. Nestor, Fredrik Barrenäs, Hui Wang, Antonio Lentini, Huan Zhang, Sören Bruhn, Rebecka Jörnsten, Michael A. Langston, Gary Rogers, Mika Gustafsson, Mikael Benson

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004059

A Nonsense Mutation in TMEM95 Encoding a Nondescript Transmembrane Protein Causes Idiopathic Male Subfertility in Cattle

Hubert Pausch, Sabine Kölle, Christine Wurmser, Hermann Schwarzenbacher, Reiner Emmerling, Sandra Jansen, Matthias Trottmann, Christian Fuerst, Kay-Uwe Götz, Ruedi Fries

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004044

In-Vivo Quantitative Proteomics Reveals a Key Contribution of Post-Transcriptional Mechanisms to the Circadian Regulation of Liver Metabolism

Maria S. Robles, Jürgen Cox, Matthias Mann

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004047

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

Nadia Hégarat, Clare Vesely, P. K. Vinod, Cory Ocasio, Nisha Peter, Julian Gannon, Antony W. Oliver, Béla Novák, Helfrid Hochegger

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004004

A Genome-Wide Screen for Bacterial Envelope Biogenesis Mutants Identifies a Novel Factor Involved in Cell Wall Precursor Metabolism

Catherine Paradis-Bleau, George Kritikos, Katya Orlova, Athanasios Typas, Thomas G. Bernhardt

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004056

ADP1 Affects Plant Architecture by Regulating Local Auxin Biosynthesis

Ruixi Li, Jieru Li, Shibai Li, Genji Qin, Ondřej Novák, Aleš Pěnčík, Karin Ljung, Takashi Aoyama, Jingjing Liu, Angus Murphy, Hongya Gu, Tomohiko Tsuge, Li-Jia Qu

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1003954

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

Ian A. Lewis, Mark Wacker, Kellen L. Olszewski, Simon A. Cobbold, Katelynn S. Baska, Asako Tan, Michael T. Ferdig, Manuel Llinás

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004085

ComEA Is Essential for the Transfer of External DNA into the Periplasm in Naturally Transformable Vibrio cholerae Cells

Patrick Seitz, Hassan Pezeshgi Modarres, Sandrine Borgeaud, Roman D. Bulushev, Lorenz J. Steinbock, Aleksandra Radenovic, Matteo Dal Peraro, Melanie Blokesch

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004066

Intrasubtype Reassortments Cause Adaptive Amino Acid Replacements in H3N2 Influenza Genes

Alexey D. Neverov, Ksenia V. Lezhnina, Alexey S. Kondrashov, Georgii A. Bazykin

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004037

Multi-tissue Analysis of Co-expression Networks by Higher-Order Generalized Singular Value Decomposition Identifies Functionally Coherent Transcriptional Modules

Xiaolin Xiao, Aida Moreno-Moral, Maxime Rotival, Leonardo Bottolo, Enrico Petretto

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004006

A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

Naveen Kumar Kadri, Goutam Sahana, Carole Charlier, Terhi Iso-Touru, Bernt Guldbrandtsen, Latifa Karim, Ulrik Sander Nielsen, Frank Panitz, Gert Pedersen Aamand, Nina Schulman, Michel Georges, Johanna Vilkki, Mogens Sandø Lund, Tom Druet

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004049

Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

Jamie T. Bridgham, June Keay, Eric A. Ortlund, Joseph W. Thornton

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004058

The Acid Phosphatase-Encoding Gene GmACP1 Contributes to Soybean Tolerance to Low-Phosphorus Stress

Dan Zhang, Haina Song, Hao Cheng, Derong Hao, Hui Wang, Guizhen Kan, Hangxia Jin, Deyue Yu

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004061

The Candidate Splicing Factor Sfswap Regulates Growth and Patterning of Inner Ear Sensory Organs

Yalda Moayedi, Martin L. Basch, Natasha L. Pacheco, Simon S. Gao, Rosalie Wang, Wilbur Harrison, Ningna Xiao, John S. Oghalai, Paul A. Overbeek, Graeme Mardon, Andrew K. Groves

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004055

Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene Transcription

Anand Balasubramani, Colleen J. Winstead, Henrietta Turner, Karen M. Janowski, Stacey N. Harbour, Yoichiro Shibata, Gregory E. Crawford, Robin D. Hatton, Casey T. Weaver

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1003969

NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human Neuroblastomas

Yusuke Suenaga, S. M. Rafiqul Islam, Jennifer Alagu, Yoshiki Kaneko, Mamoru Kato, Yukichi Tanaka, Hidetada Kawana, Shamim Hossain, Daisuke Matsumoto, Mami Yamamoto, Wataru Shoji, Makiko Itami, Tatsuhiro Shibata, Yohko Nakamura, Miki Ohira, Seiki Haraguchi, Atsushi Takatori, Akira Nakagawara

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1003996

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors

Marie S. Hasemann, Felicia K. B. Lauridsen, Johannes Waage, Janus S. Jakobsen, Anne-Katrine Frank, Mikkel B. Schuster, Nicolas Rapin, Frederik O. Bagger, Philipp S. Hoppe, Timm Schroeder, Bo T. Porse

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004079

The Transcription Factor BcLTF1 Regulates Virulence and Light Responses in the Necrotrophic Plant Pathogen Botrytis cinerea

Julia Schumacher, Adeline Simon, Kim Christopher Cohrs, Muriel Viaud, Paul Tudzynski

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004040

A PNPase Dependent CRISPR System in Listeria

Nina Sesto, Marie Touchon, José Marques Andrade, Jiro Kondo, Eduardo P. C. Rocha, Cecilia Maria Arraiano, Cristel Archambaud, Éric Westhof, Pascale Romby, Pascale Cossart

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004065

GATA6 Is a Crucial Regulator of Shh in the Limb Bud

Elena Kozhemyakina, Andreia Ionescu, Andrew B. Lassar

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004072

Evidence for Mito-Nuclear and Sex-Linked Reproductive Barriers between the Hybrid Italian Sparrow and Its Parent Species

Cassandra N. Trier, Jo S. Hermansen, Glenn-Peter Sætre, Richard I. Bailey

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004075

Nannochloropsis Genomes Reveal Evolution of Microalgal Oleaginous Traits

Dongmei Wang, Kang Ning, Jing Li, Jianqiang Hu, Danxiang Han, Hui Wang, Xiaowei Zeng, Xiaoyan Jing, Qian Zhou, Xiaoquan Su, Xingzhi Chang, Anhui Wang, Wei Wang, Jing Jia, Li Wei, Yi Xin, Yinghe Qiao, Ranran Huang, Jie Chen, Bo Han, Kangsup Yoon, Russell T. Hill, Yonathan Zohar, Feng Chen, Qiang Hu, Jian Xu

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004094

Meta-Analysis Identifies Gene-by-Environment Interactions as Demonstrated in a Study of 4,965 Mice

Eun Yong Kang, Buhm Han, Nicholas Furlotte, Jong Wha J. Joo, Diana Shih, Richard C. Davis, Aldons J. Lusis, Eleazar Eskin

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004022

Natural Selection Reduced Diversity on Human Y Chromosomes

Melissa A. Wilson Sayres, Kirk E. Lohmueller, Rasmus Nielsen

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004064

Comparative Evolutionary and Developmental Dynamics of the Cotton (Gossypium hirsutum) Fiber Transcriptome

Mi-Jeong Yoo, Jonathan F. Wendel

PLOS Genetics: published January 2, 2014 | https://doi.org/10.1371/journal.pgen.1004073

Single Nucleus Genome Sequencing Reveals High Similarity among Nuclei of an Endomycorrhizal Fungus

Kui Lin, Erik Limpens, Zhonghua Zhang, Sergey Ivanov, Diane G. O. Saunders, Desheng Mu, Erli Pang, Huifen Cao, Hwangho Cha, Tao Lin, Qian Zhou, Yi Shang, Ying Li, Trupti Sharma, Robin van Velzen, Norbert de Ruijter, Duur K. Aanen, Joe Win, Sophien Kamoun, Ton Bisseling, René Geurts, Sanwen Huang

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004078

Notch Controls Cell Adhesion in the Drosophila Eye

Sujin Bao

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004087

A forkhead Transcription Factor Is Wound-Induced at the Planarian Midline and Required for Anterior Pole Regeneration

M. Lucila Scimone, Sylvain W. Lapan, Peter W. Reddien

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1003999

p53 and TAp63 Promote Keratinocyte Proliferation and Differentiation in Breeding Tubercles of the Zebrafish

Boris Fischer, Manuel Metzger, Rebecca Richardson, Philipp Knyphausen, Thomas Ramezani, Rainer Franzen, Elmon Schmelzer, Wilhelm Bloch, Thomas J. Carney, Matthias Hammerschmidt

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004048

Evolution of Chloroplast Transcript Processing in Plasmodium and Its Chromerid Algal Relatives

Richard G. Dorrell, James Drew, R. Ellen R. Nisbet, Christopher J. Howe

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004008

Molecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments

Jungeui Hong, David Gresham

PLOS Genetics: published January 9, 2014 | https://doi.org/10.1371/journal.pgen.1004041

A Comprehensive tRNA Deletion Library Unravels the Genetic Architecture of the tRNA Pool

Zohar Bloom-Ackermann, Sivan Navon, Hila Gingold, Ruth Towers, Yitzhak Pilpel, Orna Dahan

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004084

Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause Regions

John M. Pagano, Hojoong Kwak, Colin T. Waters, Rebekka O. Sprouse, Brian S. White, Abdullah Ozer, Kylan Szeto, David Shalloway, Harold G. Craighead, John T. Lis

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004090

Genome Sequencing Highlights the Dynamic Early History of Dogs

Adam H. Freedman, Ilan Gronau, Rena M. Schweizer, Diego Ortega-Del Vecchyo, Eunjung Han, Pedro M. Silva, Marco Galaverni, Zhenxin Fan, Peter Marx, Belen Lorente-Galdos, Holly Beale, Oscar Ramirez, Farhad Hormozdiari, Can Alkan, Carles Vilà, Kevin Squire, Eli Geffen, Josip Kusak, Adam R. Boyko, Heidi G. Parker, Clarence Lee, Vasisht Tadigotla, Adam Siepel, Carlos D. Bustamante, Timothy T. Harkins, Stanley F. Nelson, Elaine A. Ostrander, Tomas Marques-Bonet, Robert K. Wayne, John Novembre

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004016

Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses

Geoffrey D. Findlay, Jessica L. Sitnik, Wenke Wang, Charles F. Aquadro, Nathan L. Clark, Mariana F. Wolfner

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004108

Regulation of Synaptic nlg-1/Neuroligin Abundance by the skn-1/Nrf Stress Response Pathway Protects against Oxidative Stress

Trisha A. Staab, Oleg Egrafov, James A. Knowles, Derek Sieburth

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004100

Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution

Sarah L. Maguire, Can Wang, Linda M. Holland, François Brunel, Cécile Neuvéglise, Jean-Marc Nicaud, Martin Zavrel, Theodore C. White, Kenneth H. Wolfe, Geraldine Butler

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004076

A Cell Cycle and Nutritional Checkpoint Controlling Bacterial Surface Adhesion

Aretha Fiebig, Julien Herrou, Coralie Fumeaux, Sunish K. Radhakrishnan, Patrick H. Viollier, Sean Crosson

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004101

Developmental Link between Sex and Nutrition; doublesex Regulates Sex-Specific Mandible Growth via Juvenile Hormone Signaling in Stag Beetles

Hiroki Gotoh, Hitoshi Miyakawa, Asano Ishikawa, Yuki Ishikawa, Yasuhiro Sugime, Douglas J. Emlen, Laura C. Lavine, Toru Miura

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004098

Cell-Cycle Dependent Expression of a Translocation-Mediated Fusion Oncogene Mediates Checkpoint Adaptation in Rhabdomyosarcoma

Ken Kikuchi, Simone Hettmer, M. Imran Aslam, Joel E. Michalek, Wolfram Laub, Breelyn A. Wilky, David M. Loeb, Brian P. Rubin, Amy J. Wagers, Charles Keller

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004107

Functional Divergence and Evolutionary Turnover in Mammalian Phosphoproteomes

Luca Freschi, Mazid Osseni, Christian R. Landry

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004062

Down-Regulation of Rad51 Activity during Meiosis in Yeast Prevents Competition with Dmc1 for Repair of Double-Strand Breaks

Yan Liu, William A. Gaines, Tracy Callender, Valeria Busygina, Ashwini Oke, Patrick Sung, Jennifer C. Fung, Nancy M. Hollingsworth

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004005

Bioelectric Signaling Regulates Size in Zebrafish Fins

Simon Perathoner, Jacob M. Daane, Ulrike Henrion, Guiscard Seebohm, Charles W. Higdon, Stephen L. Johnson, Christiane Nüsslein-Volhard, Matthew P. Harris

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004080

Arabidopsis AL PHD-PRC1 Complexes Promote Seed Germination through H3K4me3-to-H3K27me3 Chromatin State Switch in Repression of Seed Developmental Genes

Anne Marie Molitor, Zhongyuan Bu, Yu Yu, Wen-Hui Shen

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004091

Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues

Erica P. Homan, Caressa Lietman, Ingo Grafe, Jennifer Lennington, Roy Morello, Dobrawa Napierala, Ming-Ming Jiang, Elda M. Munivez, Brian Dawson, Terry K. Bertin, Yuqing Chen, Rhonald Lua, Olivier Lichtarge, John Hicks, Mary Ann Weis, David Eyre, Brendan H. L. Lee

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004121

The SET Domain Proteins SUVH2 and SUVH9 Are Required for Pol V Occupancy at RNA-Directed DNA Methylation Loci

Zhang-Wei Liu, Chang-Rong Shao, Cui-Jun Zhang, Jin-Xing Zhou, Su-Wei Zhang, Lin Li, She Chen, Huan-Wei Huang, Tao Cai, Xin-Jian He

PLOS Genetics: published January 22, 2014 | https://doi.org/10.1371/journal.pgen.1003948

Loss and Recovery of Genetic Diversity in Adapting Populations of HIV

Pleuni S. Pennings, Sergey Kryazhimskiy, John Wakeley

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004000

A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast

Michael A. Kennedy, Kenneth Gable, Karolina Niewola-Staszkowska, Susana Abreu, Anne Johnston, Linda J. Harris, Fulvio Reggiori, Robbie Loewith, Teresa Dunn, Steffany A. L. Bennett, Kristin Baetz

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004010

3′ Untranslated Regions Mediate Transcriptional Interference between Convergent Genes Both Locally and Ectopically in Saccharomyces cerevisiae

Luwen Wang, Ning Jiang, Lin Wang, Ou Fang, Lindsey J. Leach, Xiaohua Hu, Zewei Luo

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004021

Genomic Confirmation of Hybridisation and Recent Inbreeding in a Vector-Isolated Leishmania Population

Matthew B. Rogers, Tim Downing, Barbara A. Smith, Hideo Imamura, Mandy Sanders, Milena Svobodova, Petr Volf, Matthew Berriman, James A. Cotton, Deborah F. Smith

PLOS Genetics: published January 16, 2014 | https://doi.org/10.1371/journal.pgen.1004092

New MicroRNAs in Drosophila—Birth, Death and Cycles of Adaptive Evolution

Yang Lyu, Yang Shen, Heng Li, Yuxin Chen, Li Guo, Yixin Zhao, Eric Hungate, Suhua Shi, Chung-I Wu, Tian Tang

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004096

Variation in Genome-Wide Levels of Meiotic Recombination Is Established at the Onset of Prophase in Mammalian Males

Brian Baier, Patricia Hunt, Karl W. Broman, Terry Hassold

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004125

FGFR1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation

Kazuya Ono, Tomoko Kita, Shigeru Sato, Paul O'Neill, Siu-Shan Mak, Marie Paschaki, Masataka Ito, Noriko Gotoh, Kiyoshi Kawakami, Yoshiki Sasai, Raj K. Ladher

PLOS Genetics: published January 23, 2014 | https://doi.org/10.1371/journal.pgen.1004118

How a Retrotransposon Exploits the Plant's Heat Stress Response for Its Activation

Vladimir V. Cavrak, Nicole Lettner, Suraj Jamge, Agata Kosarewicz, Laura Maria Bayer, Ortrun Mittelsten Scheid

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004115

Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci

Susan K. Service, Tanya M. Teslovich, Christian Fuchsberger, Vasily Ramensky, Pranav Yajnik, Daniel C. Koboldt, David E. Larson, Qunyuan Zhang, Ling Lin, Ryan Welch, Li Ding, Michael D. McLellan, Michele O'Laughlin, Catrina Fronick, Lucinda L. Fulton, Vincent Magrini, Amy Swift, Paul Elliott, Marjo-Riitta Jarvelin, Marika Kaakinen, Mark I. McCarthy, Leena Peltonen, Anneli Pouta, Lori L. Bonnycastle, Francis S. Collins, Narisu Narisu, Heather M. Stringham, Jaakko Tuomilehto, Samuli Ripatti, Robert S. Fulton, Chiara Sabatti, Richard K. Wilson, Michael Boehnke, Nelson B. Freimer

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004147

E3 Ubiquitin Ligase CHIP and NBR1-Mediated Selective Autophagy Protect Additively against Proteotoxicity in Plant Stress Responses

Jie Zhou, Yan Zhang, Jingxia Qi, Yingjin Chi, Baofang Fan, Jing-Quan Yu, Zhixiang Chen

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004116

WNT7B Promotes Bone Formation in part through mTORC1

Jianquan Chen, Xiaolin Tu, Emel Esen, Kyu Sang Joeng, Congxin Lin, Jeffrey M. Arbeit, Markus A. Rüegg, Michael N. Hall, Liang Ma, Fanxin Long

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004145

A Chaperone-Assisted Degradation Pathway Targets Kinetochore Proteins to Ensure Genome Stability

Franziska Kriegenburg, Visnja Jakopec, Esben G. Poulsen, Sofie Vincents Nielsen, Assen Roguev, Nevan Krogan, Colin Gordon, Ursula Fleig, Rasmus Hartmann-Petersen

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004140

Relationship Estimation from Whole-Genome Sequence Data

Hong Li, Gustavo Glusman, Hao Hu, Shankaracharya, Juan Caballero, Robert Hubley, David Witherspoon, Stephen L. Guthery, Denise E. Mauldin, Lynn B. Jorde, Leroy Hood, Jared C. Roach, Chad D. Huff

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004144

Loss of Histone H3 Methylation at Lysine 4 Triggers Apoptosis in Saccharomyces cerevisiae

David Walter, Anja Matter, Birthe Fahrenkrog

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004095

Down-Regulation of eIF4GII by miR-520c-3p Represses Diffuse Large B Cell Lymphoma Development

Krystyna Mazan-Mamczarz, X. Frank Zhao, Bojie Dai, James J. Steinhardt, Raymond J. Peroutka, Kimberly L. Berk, Ari L. Landon, Mariola Sadowska, Yongqing Zhang, Elin Lehrmann, Kevin G. Becker, Rita Shaknovich, Zhenqiu Liu, Ronald B. Gartenhaus

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004105

Large Inverted Duplications in the Human Genome Form via a Fold-Back Mechanism

Karen E. Hermetz, Scott Newman, Karen N. Conneely, Christa L. Martin, Blake C. Ballif, Lisa G. Shaffer, Jannine D. Cody, M. Katharine Rudd

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004139

Tissue Specific Roles for the Ribosome Biogenesis Factor Wdr43 in Zebrafish Development

Chengtian Zhao, Viktoria Andreeva, Yann Gibert, Melissa LaBonty, Victoria Lattanzi, Shubhangi Prabhudesai, Yi Zhou, Leonard Zon, Kathleen L. McCann, Susan Baserga, Pamela C. Yelick

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004074

Genetic Models of Apoptosis-Induced Proliferation Decipher Activation of JNK and Identify a Requirement of EGFR Signaling for Tissue Regenerative Responses in Drosophila

Yun Fan, Shiuan Wang, Jacob Hernandez, Vildan Betul Yenigun, Gillian Hertlein, Caitlin E. Fogarty, Jillian L. Lindblad, Andreas Bergmann

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004131

Comprehensive Functional Annotation of 77 Prostate Cancer Risk Loci

Dennis J. Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L. Lakeland, Simon G. Coetzee, Ellipse/GAME-ON consortium, Practical consortium, Brian E. Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A. Eeles, Douglas F. Easton, Christopher A. Haiman, Wange Lu, Peggy J. Farnham, Gerhard A. Coetzee

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004102

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

Mitja I. Kurki, Emília Ilona Gaál, Johannes Kettunen, Tuuli Lappalainen, Androniki Menelaou, Verneri Anttila, Femke N. G. van 't Hof, Mikael von und zu Fraunberg, Seppo Helisalmi, Mikko Hiltunen, Hanna Lehto, Aki Laakso, Riku Kivisaari, Timo Koivisto, Antti Ronkainen, Jaakko Rinne, Lambertus A. L. Kiemeney, Sita H. Vermeulen, Mari A. Kaunisto, Johan G. Eriksson, Arpo Aromaa, Markus Perola, Terho Lehtimäki, Olli T. Raitakari, Veikko Salomaa, Murat Gunel, Emmanouil T. Dermitzakis, Ynte M. Ruigrok, Gabriel J. E. Rinkel, Mika Niemelä, Juha Hernesniemi, Samuli Ripatti, Paul I. W. de Bakker, Aarno Palotie, Juha E. Jääskeläinen

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004134

Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan

Alexander M. Kulminski, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Kaare Christensen, Nicole Schupf, Michael A. Province, Anatoli I. Yashin

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004141

Crossover Patterning by the Beam-Film Model: Analysis and Implications

Liangran Zhang, Zhangyi Liang, John Hutchinson, Nancy Kleckner

PLOS Genetics: published January 30, 2014 | https://doi.org/10.1371/journal.pgen.1004042

Cover

The sexually dimorphic stag beetle.

Perspectives

Related Articles

Related Articles

Related Articles

Reviews

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles

Related Articles