January 2013

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

Sarah A. Pendergrass, Kristin Brown-Gentry, Scott Dudek, Alex Frase, Eric S. Torstenson, Robert Goodloe, Jose Luis Ambite, Christy L. Avery, Steve Buyske, Petra Bůžková, Ewa Deelman, Megan D. Fesinmeyer, Christopher A. Haiman, Gerardo Heiss, Lucia A. Hindorff, Chu-Nan Hsu, Rebecca D. Jackson, Charles Kooperberg, Loic Le Marchand, Yi Lin, Tara C. Matise, Kristine R. Monroe, Larry Moreland, Sungshim L. Park, Alex Reiner, Robert Wallace, Lynn R. Wilkens, Dana C. Crawford, Marylyn D. Ritchie

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003087

Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

Dawn E. Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E. Leeds, Raymond Mullen, Laura L. Baxter, Thomas G. Campbell, Marion C. Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H. Douglas Morris, Johannes Riegler, Mark F. Lythgoe, Ruth M. Arkell, Fabrizio Loreni, Jonathan Flint, William J. Pavan, David A. Keays

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003094

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene

Dario Nicetto, Matthias Hahn, Julia Jung, Tobias D. Schneider, Tobias Straub, Robert David, Gunnar Schotta, Ralph A. W. Rupp

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003188

Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations

Katherine R. Bull, Andrew J. Rimmer, Owen M. Siggs, Lisa A. Miosge, Carla M. Roots, Anselm Enders, Edward M. Bertram, Tanya L. Crockford, Belinda Whittle, Paul K. Potter, Michelle M. Simon, Ann-Marie Mallon, Steve D. M. Brown, Bruce Beutler, Christopher C. Goodnow, Gerton Lunter, Richard J. Cornall

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003219

Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

Gordan Lauc, Jennifer E. Huffman, Maja Pučić, Lina Zgaga, Barbara Adamczyk, Ana Mužinić, Mislav Novokmet, Ozren Polašek, Olga Gornik, Jasminka Krištić, Toma Keser, Veronique Vitart, Blanca Scheijen, Hae-Won Uh, Mariam Molokhia, Alan Leslie Patrick, Paul McKeigue, Ivana Kolčić, Ivan Krešimir Lukić, Olivia Swann, Frank N. van Leeuwen, L. Renee Ruhaak, Jeanine J. Houwing-Duistermaat, P. Eline Slagboom, Marian Beekman, Anton J. M. de Craen, André M. Deelder, Qiang Zeng, Wei Wang, Nicholas D. Hastie, Ulf Gyllensten, James F. Wilson, Manfred Wuhrer, Alan F. Wright, Pauline M. Rudd, Caroline Hayward, Yurii Aulchenko, Harry Campbell, Igor Rudan

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003225

HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in Drosophila melanogaster

Yan Li, Divya Padmanabha, Luciana B. Gentile, Catherine I. Dumur, Robert B. Beckstead, Keith D. Baker

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003230

An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila

Colin D. Meiklejohn, Marissa A. Holmbeck, Mohammad A. Siddiq, Dawn N. Abt, David M. Rand, Kristi L. Montooth

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003238

Genome-Wide Haplotype Analysis of Cis Expression Quantitative Trait Loci in Monocytes

Sophie Garnier, Vinh Truong, Jessy Brocheton, Tanja Zeller, Maxime Rovital, Philipp S. Wild, Andreas Ziegler, The Cardiogenics Consortium, Thomas Munzel, Laurence Tiret, Stefan Blankenberg, Panos Deloukas, Jeannette Erdmann, Christian Hengstenberg, Nilesh J. Samani, Heribert Schunkert, Willem H. Ouwehand, Alison H. Goodall, François Cambien, David-Alexandre Trégouët

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003240

A Quartet of PIF bHLH Factors Provides a Transcriptionally Centered Signaling Hub That Regulates Seedling Morphogenesis through Differential Expression-Patterning of Shared Target Genes in Arabidopsis

Yu Zhang, Oleg Mayba, Anne Pfeiffer, Hui Shi, James M. Tepperman, Terence P. Speed, Peter H. Quail

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003244

The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation

Aiko Matsui, Yoshiaki Kamada, Akira Matsuura

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003245

An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development

Derek M. van Pel, Irene J. Barrett, Yoko Shimizu, Babu V. Sajesh, Brent J. Guppy, Tom Pfeifer, Kirk J. McManus, Philip Hieter

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003254

The [PSI⁺] Prion Exists as a Dynamic Cloud of Variants

David A. Bateman, Reed B. Wickner

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003257

Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis

Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Prakash M. Hande, Otto Sanchez, Razqallah Hakem

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003259

The Meiotic Nuclear Lamina Regulates Chromosome Dynamics and Promotes Efficient Homologous Recombination in the Mouse

Jana Link, Daniel Jahn, Johannes Schmitt, Eva Göb, Johannes Baar, Sagrario Ortega, Ricardo Benavente, Manfred Alsheimer

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003261

Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor

David Ontoso, Isabel Acosta, Fred van Leeuwen, Raimundo Freire, Pedro A. San-Segundo

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003262

Retroactive Maintains Cuticle Integrity by Promoting the Trafficking of Knickkopf into the Procuticle of Tribolium castaneum

Sujata S. Chaudhari, Yasuyuki Arakane, Charles A. Specht, Bernard Moussian, Karl J. Kramer, Subbaratnam Muthukrishnan, Richard W. Beeman

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003268

A Heterogeneous Mixture of F-Series Prostaglandins Promotes Sperm Guidance in the Caenorhabditis elegans Reproductive Tract

Hieu D. Hoang, Jeevan K. Prasain, Dixon Dorand, Michael A. Miller

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003271

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

Ashleigh E. Schaffer, Brandon L. Taylor, Jacqueline R. Benthuysen, Jingxuan Liu, Fabrizio Thorel, Weiping Yuan, Yang Jiao, Klaus H. Kaestner, Pedro L. Herrera, Mark A. Magnuson, Catherine Lee May, Maike Sander

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003274

The Flowering Repressor SVP Underlies a Novel Arabidopsis thaliana QTL Interacting with the Genetic Background

Belén Méndez-Vigo, José M. Martínez-Zapater, Carlos Alonso-Blanco

PLOS Genetics: published January 31, 2013 | https://doi.org/10.1371/journal.pgen.1003289

Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry

Kari F. Lenhart, Nathalia G. Holtzman, Jessica R. Williams, Rebecca D. Burdine

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003109

Sequencing of Pax6 Loci from the Elephant Shark Reveals a Family of Pax6 Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences

Vydianathan Ravi, Shipra Bhatia, Philippe Gautier, Felix Loosli, Boon-Hui Tay, Alice Tay, Emma Murdoch, Pedro Coutinho, Veronica van Heyningen, Sydney Brenner, Byrappa Venkatesh, Dirk A. Kleinjan

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003177

An EAV-HP Insertion in 5′ Flanking Region of SLCO1B3 Causes Blue Eggshell in the Chicken

Zhepeng Wang, Lujiang Qu, Junfeng Yao, Xiaolin Yang, Guangqi Li, Yuanyuan Zhang, Junying Li, Xiaotong Wang, Jirong Bai, Guiyun Xu, Xuemei Deng, Ning Yang, Changxin Wu

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003183

Genetic and Functional Modularity of Hox Activities in the Specification of Limb-Innervating Motor Neurons

Julie Lacombe, Olivia Hanley, Heekyung Jung, Polyxeni Philippidou, Gulsen Surmeli, Jonathan Grinstein, Jeremy S. Dasen

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003184

Sex-Specific Signaling in the Blood–Brain Barrier Is Required for Male Courtship in Drosophila

Valbona Hoxha, Chamala Lama, Peter L. Chang, Sumit Saurabh, Naiya Patel, Nicole Olate, Brigitte Dauwalder

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003217

A Hybrid Likelihood Model for Sequence-Based Disease Association Studies

Yun-Ching Chen, Hannah Carter, Jennifer Parla, Melissa Kramer, Fernando S. Goes, Mehdi Pirooznia, Peter P. Zandi, W. Richard McCombie, James B. Potash, Rachel Karchin

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003224

Delineating a Conserved Genetic Cassette Promoting Outgrowth of Body Appendages

Congxing Lin, Yan Yin, Sheila M. Bell, G. Michael Veith, Hong Chen, Sung-Ho Huh, David M. Ornitz, Liang Ma

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003231

Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations

Shang-Lin Chang, Huei-Yi Lai, Shu-Yun Tung, Jun-Yi Leu

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003232

Comparative Genome Structure, Secondary Metabolite, and Effector Coding Capacity across Cochliobolus Pathogens

Bradford J. Condon, Yueqiang Leng, Dongliang Wu, Kathryn E. Bushley, Robin A. Ohm, Robert Otillar, Joel Martin, Wendy Schackwitz, Jane Grimwood, NurAinIzzati MohdZainudin, Chunsheng Xue, Rui Wang, Viola A. Manning, Braham Dhillon, Zheng Jin Tu, Brian J. Steffenson, Asaf Salamov, Hui Sun, Steve Lowry, Kurt LaButti, James Han, Alex Copeland, Erika Lindquist, Kerrie Barry, Jeremy Schmutz, Scott E. Baker, Lynda M. Ciuffetti, Igor V. Grigoriev, Shaobin Zhong, B. Gillian Turgeon

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003233

TATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association Studies

Sophie van der Sluis, Danielle Posthuma, Conor V. Dolan

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003235

Heterologous Gln/Asn-Rich Proteins Impede the Propagation of Yeast Prions by Altering Chaperone Availability

Zi Yang, Joo Y. Hong, Irina L. Derkatch, Susan W. Liebman

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003236

Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid

Sandra Muñoz-Galván, Sonia Jimeno, Rodney Rothstein, Andrés Aguilera

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003237

Structural Basis of a Histone H3 Lysine 4 Demethylase Required for Stem Elongation in Rice

Qingfeng Chen, Xiangsong Chen, Quan Wang, Faben Zhang, Zhiyong Lou, Qifa Zhang, Dao-Xiu Zhou

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003239

Gene Copy-Number Polymorphism Caused by Retrotransposition in Humans

Daniel R. Schrider, Fabio C. P. Navarro, Pedro A. F. Galante, Raphael B. Parmigiani, Anamaria A. Camargo, Matthew W. Hahn, Sandro J. de Souza

PLOS Genetics: published January 24, 2013 | https://doi.org/10.1371/journal.pgen.1003242

Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies

Miao-Xin Li, Johnny S. H. Kwan, Su-Ying Bao, Wanling Yang, Shu-Leong Ho, Yong-Qiang Song, Pak C. Sham

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003143

E. coli Fis Protein Insulates the cbpA Gene from Uncontrolled Transcription

Kiran Chintakayala, Shivani S. Singh, Amanda E. Rossiter, Rajesh Shahapure, Remus T. Dame, David C. Grainger

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003152

Integrative Genomics in Combination with RNA Interference Identifies Prognostic and Functionally Relevant Gene Targets for Oral Squamous Cell Carcinoma

Chang Xu, Pei Wang, Yan Liu, Yuzheng Zhang, Wenhong Fan, Melissa P. Upton, Pawadee Lohavanichbutr, John R. Houck, David R. Doody, Neal D. Futran, Lue Ping Zhao, Stephen M. Schwartz, Chu Chen, Eduardo Méndez

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003169

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

Ulrike Peters, Kari E. North, Praveen Sethupathy, Steve Buyske, Jeff Haessler, Shuo Jiao, Megan D. Fesinmeyer, Rebecca D. Jackson, Lew H. Kuller, Aleksandar Rajkovic, Unhee Lim, Iona Cheng, Fred Schumacher, Lynne Wilkens, Rongling Li, Keri Monda, Georg Ehret, Khanh-Dung H. Nguyen, Richard Cooper, Cora E. Lewis, Mark Leppert, Marguerite R. Irvin, C. Charles Gu, Denise Houston, Petra Buzkova, Marylyn Ritchie, Tara C. Matise, Loic Le Marchand, Lucia A. Hindorff, Dana C. Crawford, Christopher A. Haiman, Charles Kooperberg

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003171

Genetic Disruption of the Copulatory Plug in Mice Leads to Severely Reduced Fertility

Matthew D. Dean

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003185

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b

Timo H-W. Lüdtke, Henner F. Farin, Carsten Rudat, Karin Schuster-Gossler, Marianne Petry, Phil Barnett, Vincent M. Christoffels, Andreas Kispert

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003189

Genome-Wide Association Study Identifies a Novel Susceptibility Locus at 12q23.1 for Lung Squamous Cell Carcinoma in Han Chinese

Jing Dong, Guangfu Jin, Chen Wu, Huan Guo, Baosen Zhou, Jiachun Lv, Daru Lu, Yongyong Shi, Yongqian Shu, Lin Xu, Minjie Chu, Cheng Wang, Ruyang Zhang, Juncheng Dai, Yue Jiang, Dianke Yu, Hongxia Ma, Xueying Zhao, Zhihua Yin, Lei Yang, Zhiqiang Li, Qifei Deng, Songyu Cao, Zhenzhen Qin, Jianhang Gong, Chongqi Sun, Jiucun Wang, Wei Wu, Guoquan Zhou, Hongyan Chen, Peng Guan, Yijiang Chen, Xiangyang Liu, Li Liu, Pin Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Jibin Liu, Christopher I. Amos, Feng Chen, Wen Tan, Li Jin, Tangchun Wu, Zhibin Hu, Dongxin Lin, Hongbing Shen

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003190

Secondary Metabolism and Development Is Mediated by LlmF Control of VeA Subcellular Localization in Aspergillus nidulans

Jonathan M. Palmer, Jeffrey M. Theisen, Rocio M. Duran, W. Scott Grayburn, Ana M. Calvo, Nancy P. Keller

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003193

NBR1-Mediated Selective Autophagy Targets Insoluble Ubiquitinated Protein Aggregates in Plant Stress Responses

Jie Zhou, Jian Wang, Yuan Cheng, Ying-Jun Chi, Baofang Fan, Jing-Quan Yu, Zhixiang Chen

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003196

Multiple Opposing Constraints Govern Chromosome Interactions during Meiosis

Doris Y. Lui, Cori K. Cahoon, Sean M. Burgess

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003197

Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression

Vinod Kumar, Harm-Jan Westra, Juha Karjalainen, Daria V. Zhernakova, Tõnu Esko, Barbara Hrdlickova, Rodrigo Almeida, Alexandra Zhernakova, Eva Reinmaa, Urmo Võsa, Marten H. Hofker, Rudolf S. N. Fehrmann, Jingyuan Fu, Sebo Withoff, Andres Metspalu, Lude Franke, Cisca Wijmenga

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003201

Mendelian and Non-Mendelian Regulation of Gene Expression in Maize

Lin Li, Katherine Petsch, Rena Shimizu, Sanzhen Liu, Wayne Wenzhong Xu, Kai Ying, Jianming Yu, Michael J. Scanlon, Patrick S. Schnable, Marja C. P. Timmermans, Nathan M. Springer, Gary J. Muehlbauer

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003202

Positional Cloning Reveals Strain-Dependent Expression of Trim16 to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice

Anguel N. Stefanov, Jessica Fox, Christina K. Haston

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003203

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice

Rebecca E. Mercer, Sheldon D. Michaelson, Melissa J. S. Chee, Tanya A. Atallah, Rachel Wevrick, William F. Colmers

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003207

Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators

Yan Hu, Hong-Bo Tang, Ning-Ning Liu, Xia-Jing Tong, Wei Dang, Yi-Min Duan, Xiao-Hong Fu, Yang Zhang, Jing Peng, Fei-Long Meng, Jin-Qiu Zhou

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003208

Centromere-Like Regions in the Budding Yeast Genome

Philippe Lefrançois, Raymond K. Auerbach, Christopher M. Yellman, G. Shirleen Roeder, Michael Snyder

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003209

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

Philippe Cloutier, Mathieu Lavallée-Adam, Denis Faubert, Mathieu Blanchette, Benoit Coulombe

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003210

Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds

Jessica L. Petersen, James R. Mickelson, Aaron K. Rendahl, Stephanie J. Valberg, Lisa S. Andersson, Jeanette Axelsson, Ernie Bailey, Danika Bannasch, Matthew M. Binns, Alexandre S. Borges, Pieter Brama, Artur da Câmara Machado, Stefano Capomaccio, Katia Cappelli, E. Gus Cothran, Ottmar Distl, Laura Fox-Clipsham, Kathryn T. Graves, Gérard Guérin, Bianca Haase, Telhisa Hasegawa, Karin Hemmann, Emmeline W. Hill, Tosso Leeb, Gabriella Lindgren, Hannes Lohi, Maria Susana Lopes, Beatrice A. McGivney, Sofia Mikko, Nicholas Orr, M. Cecilia T. Penedo, Richard J. Piercy, Marja Raekallio, Stefan Rieder, Knut H. Røed, June Swinburne, Teruaki Tozaki, Mark Vaudin, Claire M. Wade, Molly E. McCue

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003211

Coordinated Degradation of Replisome Components Ensures Genome Stability upon Replication Stress in the Absence of the Replication Fork Protection Complex

Laura C. Roseaulin, Chiaki Noguchi, Esteban Martinez, Melissa A. Ziegler, Takashi Toda, Eishi Noguchi

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003213

Telomerase Is Required for Zebrafish Lifespan

Catarina M. Henriques, Madalena C. Carneiro, Inês M. Tenente, António Jacinto, Miguel Godinho Ferreira

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003214

Switchgrass Genomic Diversity, Ploidy, and Evolution: Novel Insights from a Network-Based SNP Discovery Protocol

Fei Lu, Alexander E. Lipka, Jeff Glaubitz, Rob Elshire, Jerome H. Cherney, Michael D. Casler, Edward S. Buckler, Denise E. Costich

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003215

POWERDRESS and Diversified Expression of the MIR172 Gene Family Bolster the Floral Stem Cell Network

Rae Eden Yumul, Yun Ju Kim, Xigang Liu, Ruozhong Wang, Junhui Ding, Langtao Xiao, Xuemei Chen

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003218

Susceptibility Loci Associated with Specific and Shared Subtypes of Lymphoid Malignancies

Joseph Vijai, Tomas Kirchhoff, Kasmintan A. Schrader, Jennifer Brown, Ana Virginia Dutra-Clarke, Christopher Manschreck, Nichole Hansen, Rohini Rau-Murthy, Kara Sarrel, Jennifer Przybylo, Sohela Shah, Srujana Cheguri, Zsofia Stadler, Liying Zhang, Ora Paltiel, Dina Ben-Yehuda, Agnes Viale, Carol Portlock, David Straus, Steven M. Lipkin, Mortimer Lacher, Mark Robson, Robert J. Klein, Andrew Zelenetz, Kenneth Offit

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003220

Function and Regulation of AUTS2, a Gene Implicated in Autism and Human Evolution

Nir Oksenberg, Laurie Stevison, Jeffrey D. Wall, Nadav Ahituv

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003221

Transcription of the Major Neurospora crassa microRNA–Like Small RNAs Relies on RNA Polymerase III

Qiuying Yang, Liande Li, Zhihong Xue, Qiaohong Ye, Lin Zhang, Shaojie Li, Yi Liu

PLOS Genetics: published January 17, 2013 | https://doi.org/10.1371/journal.pgen.1003227

Comparative Genomic Analysis of the Endosymbionts of Herbivorous Insects Reveals Eco-Environmental Adaptations: Biotechnology Applications

Weibing Shi, Shangxian Xie, Xueyan Chen, Su Sun, Xin Zhou, Lantao Liu, Peng Gao, Nikos C. Kyrpides, En-Gyu No, Joshua S. Yuan

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003131

MAML1 Enhances the Transcriptional Activity of Runx2 and Plays a Role in Bone Development

Takashi Watanabe, Toshinao Oyama, Maki Asada, Daisuke Harada, Yoshiaki Ito, Masayo Inagawa, Yutaka Suzuki, Sumio Sugano, Ken-ichi Katsube, Gerard Karsenty, Toshihisa Komori, Motoo Kitagawa, Hiroshi Asahara

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003132

Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity

Subhajyoti De, Rita Shaknovich, Markus Riester, Olivier Elemento, Huimin Geng, Matthias Kormaksson, Yanwen Jiang, Bruce Woolcock, Nathalie Johnson, Jose M. Polo, Leandro Cerchietti, Randy D. Gascoyne, Ari Melnick, Franziska Michor

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003137

A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)

Rohina Rubicz, Robert Yolken, Eugene Drigalenko, Melanie A. Carless, Thomas D. Dyer, Lara Bauman, Phillip E. Melton, Jack W. Kent Jr., John B. Harley, Joanne E. Curran, Matthew P. Johnson, Shelley A. Cole, Laura Almasy, Eric K. Moses, Nikhil V. Dhurandhar, Ellen Kraig, John Blangero, Charles T. Leach, Harald H. H. Göring

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003147

Importance of Polη for Damage-Induced Cohesion Reveals Differential Regulation of Cohesion Establishment at the Break Site and Genome-Wide

Elin Enervald, Emma Lindgren, Yuki Katou, Katsuhiko Shirahige, Lena Ström

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003158

Increased Maternal Genome Dosage Bypasses the Requirement of the FIS Polycomb Repressive Complex 2 in Arabidopsis Seed Development

David Kradolfer, Lars Hennig, Claudia Köhler

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003163

Mutational Spectrum Drives the Rise of Mutator Bacteria

Alejandro Couce, Javier R. Guelfo, Jesús Blázquez

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003167

A Drosophila Model of High Sugar Diet-Induced Cardiomyopathy

Jianbo Na, Laura Palanker Musselman, Jay Pendse, Thomas J. Baranski, Rolf Bodmer, Karen Ocorr, Ross Cagan

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003175

A Population Genetic Model for the Maintenance of R2 Retrotransposons in rRNA Gene Loci

Jun Zhou, Michael T. Eickbush, Thomas H. Eickbush

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003179

The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast

Neil Humphryes, Wing-Kit Leung, Bilge Argunhan, Yaroslav Terentyev, Martina Dvorackova, Hideo Tsubouchi

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003194

Genome-Wide Screens for In Vivo Tinman Binding Sites Identify Cardiac Enhancers with Diverse Functional Architectures

Hong Jin, Robert Stojnic, Boris Adryan, Anil Ozdemir, Angelike Stathopoulos, Manfred Frasch

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003195

A Conserved Helicase Processivity Factor Is Needed for Conjugation and Replication of an Integrative and Conjugative Element

Jacob Thomas, Catherine A. Lee, Alan D. Grossman

PLOS Genetics: published January 10, 2013 | https://doi.org/10.1371/journal.pgen.1003198

Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in Staphylococcus aureus

Paul J. T. Johnson, Bruce R. Levin

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003123

WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates KCC2 Expression and Posterior Lateral Line Development in Zebrafish (Danio rerio)

Valérie Bercier, Edna Brustein, Meijiang Liao, Patrick A. Dion, Ronald G. Lafrenière, Guy A. Rouleau, Pierre Drapeau

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003124

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

Steve P. Bernier, David Lebeaux, Alicia S. DeFrancesco, Amandine Valomon, Guillaume Soubigou, Jean-Yves Coppée, Jean-Marc Ghigo, Christophe Beloin

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003144

The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures

Neal F. Lue, Ruobo Zhou, Lidia Chico, Ninghui Mao, Olga Steinberg-Neifach, Taekjip Ha

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003145

Post-Transcriptional Control of the Escherichia coli PhoQ-PhoP Two-Component System by Multiple sRNAs Involves a Novel Pairing Region of GcvB

Audrey Coornaert, Claude Chiaruttini, Mathias Springer, Maude Guillier

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003156

Insulin and IGF1 Receptors Are Essential for XX and XY Gonadal Differentiation and Adrenal Development in Mice

Jean-Luc Pitetti, Pierre Calvel, Yannick Romero, Béatrice Conne, Vy Truong, Marilena D. Papaioannou, Olivier Schaad, Mylène Docquier, Pedro Luis Herrera, Dagmar Wilhelm, Serge Nef

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003160

Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes

Ben E. Housden, Audrey Q. Fu, Alena Krejci, Fred Bernard, Bettina Fischer, Simon Tavaré, Steven Russell, Sarah J. Bray

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003162

MCM8 Is Required for a Pathway of Meiotic Double-Strand Break Repair Independent of DMC1 in Arabidopsis thaliana

Wayne Crismani, Virginie Portemer, Nicole Froger, Liudmila Chelysheva, Christine Horlow, Nathalie Vrielynck, Raphaël Mercier

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003165

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

Fiona McMurray, Chris D. Church, Rachel Larder, George Nicholson, Sara Wells, Lydia Teboul, Y. C. Loraine Tung, Debra Rimmington, Fatima Bosch, Veronica Jimenez, Giles S. H. Yeo, Stephen O'Rahilly, Frances M. Ashcroft, Anthony P. Coll, Roger D. Cox

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003166

The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Saccharomyces cerevisiae Genes

Mario A. Fares, Orla M. Keane, Christina Toft, Lorenzo Carretero-Paulet, Gary W. Jones

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003176

MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals

Anna Wredenberg, Marie Lagouge, Ana Bratic, Metodi D. Metodiev, Henrik Spåhr, Arnaud Mourier, Christoph Freyer, Benedetta Ruzzenente, Luke Tain, Sebastian Grönke, Francesca Baggio, Christian Kukat, Elisabeth Kremmer, Rolf Wibom, Paola Loguercio Polosa, Bianca Habermann, Linda Partridge, Chan Bae Park, Nils-Göran Larsson

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003178

β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive Carcinoma

Jeffrey C. Francis, Martin K. Thomsen, Makoto M. Taketo, Amanda Swain

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003180

Alternative Oxidase Expression in the Mouse Enables Bypassing Cytochrome c Oxidase Blockade and Limits Mitochondrial ROS Overproduction

Riyad El-Khoury, Eric Dufour, Malgorzata Rak, Nelina Ramanantsoa, Nicolas Grandchamp, Zsolt Csaba, Bertrand Duvillié, Paule Bénit, Jorge Gallego, Pierre Gressens, Chamsy Sarkis, Howard T. Jacobs, Pierre Rustin

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003182

Rbfox1 Downregulation and Altered Calpain 3 Splicing by FRG1 in a Mouse Model of Facioscapulohumeral Muscular Dystrophy (FSHD)

Mariaelena Pistoni, Lily Shiue, Melissa S. Cline, Sergia Bortolanza, Maria Victoria Neguembor, Alexandros Xynos, Manuel Ares Jr., Davide Gabellini

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003186

Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code

Manuel M. Müller, Jane R. Allison, Narupat Hongdilokkul, Laurent Gaillon, Peter Kast, Wilfred F. van Gunsteren, Philippe Marlière, Donald Hilvert

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003187

Comprehensive Methylome Characterization of Mycoplasma genitalium and Mycoplasma pneumoniae at Single-Base Resolution

Maria Lluch-Senar, Khai Luong, Verónica Lloréns-Rico, Javier Delgado, Gang Fang, Kristi Spittle, Tyson A. Clark, Eric Schadt, Stephen W. Turner, Jonas Korlach, Luis Serrano

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003191

Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination

Kenneth J. Finn, Joachim J. Li

PLOS Genetics: published January 3, 2013 | https://doi.org/10.1371/journal.pgen.1003192

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