Cover
The ER in abstraction.
The endoplasmic reticulum is depicted crowded with proteins at varied stages in synthesis and folding. The study of Richardson et al. supports the concept that the Unfolded Protein Response is activated and maintains ER homeostasis during physiological conditions such as larval development and innate immunity.
Image Credit: Stephanie Kinkel (Massachusetts Institute of Technology)
Perspectives
For Male Caenorhabditis elegans, Sperm Activation Is a “Just-in-Time” Event
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002392
Related Articles
De Novo Origins of Human Genes
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002381
Related Articles
Research Articles
Role of Pirh2 in Mediating the Regulation of p53 and c-Myc
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002360
The SUN Protein Mps3 Is Required for Spindle Pole Body Insertion into the Nuclear Membrane and Nuclear Envelope Homeostasis
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002365
PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002368
The NF1 Gene Contains Hotspots for L1 Endonuclease-Dependent De Novo Insertion
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002371
Heritable Epigenetic Variation among Maize Inbreds
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002372
TRY-5 Is a Sperm-Activating Protease in Caenorhabditis elegans Seminal Fluid
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002375
Related Articles
Genetic Interaction Maps in Escherichia coli Reveal Functional Crosstalk among Cell Envelope Biogenesis Pathways
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002377
Effect of Host Species on the Distribution of Mutational Fitness Effects for an RNA Virus
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002378
Distinct Genetic Architectures for Male and Female Inflorescence Traits of Maize
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002383
Evidence-Based Annotation of Gene Function in Shewanella oneidensis MR-1 Using Genome-Wide Fitness Profiling across 121 Conditions
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002385
Physiological IRE-1-XBP-1 and PEK-1 Signaling in Caenorhabditis elegans Larval Development and Immunity
PLOS Genetics: published November 17, 2011 | https://doi.org/10.1371/journal.pgen.1002391
Related Articles
Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002334
Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002353
Serratia symbiotica from the Aphid Cinara cedri: A Missing Link from Facultative to Obligate Insect Endosymbiont
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002357
Caenorhabditis elegans Cyclin D/CDK4 and Cyclin E/CDK2 Induce Distinct Cell Cycle Re-Entry Programs in Differentiated Muscle Cells
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002362
Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002363
Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002364
Arabidopsis Homologs of Retinoblastoma-Associated Protein 46/48 Associate with a Histone Deacetylase to Act Redundantly in Chromatin Silencing
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002366
The ERI-6/7 Helicase Acts at the First Stage of an siRNA Amplification Pathway That Targets Recent Gene Duplications
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002369
FOXO Regulates Organ-Specific Phenotypic Plasticity In Drosophila
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002373
Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002376
De Novo Origin of Human Protein-Coding Genes
PLOS Genetics: published November 10, 2011 | https://doi.org/10.1371/journal.pgen.1002379
Related Articles
Drosophila Duplication Hotspots Are Associated with Late-Replicating Regions of the Genome
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002340
Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002344
Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002348
Attenuation of the Sensing Capabilities of PhoQ in Transition to Obligate Insect–Bacterial Association
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002349
Pch2 Acts through Xrs2 and Tel1/ATM to Modulate Interhomolog Bias and Checkpoint Function during Meiosis
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002351
Recessive Antimorphic Alleles Overcome Functionally Redundant Loci to Reveal TSO1 Function in Arabidopsis Flowers and Meristems
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002352
Genome-Wide Crossover Distribution in Arabidopsis thaliana Meiosis Reveals Sex-Specific Patterns along Chromosomes
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002354
Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002355
Related Articles
SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002356
A Novel Protein LZTFL1 Regulates Ciliary Trafficking of the BBSome and Smoothened
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002358
Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002359
Short Day–Mediated Cessation of Growth Requires the Downregulation of AINTEGUMENTALIKE1 Transcription Factor in Hybrid Aspen
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002361
PcG Complexes Set the Stage for Epigenetic Inheritance of Gene Silencing in Early S Phase before Replication
PLOS Genetics: published November 3, 2011 | https://doi.org/10.1371/journal.pgen.1002370