Infectious diseases like malaria are major causes of morbidity and mortality in Sub-Saharan Africa. These microbes are able to rapidly evolve resistance to the drug treatments we develop, threatening our ability to treat these diseases, and placing millions at great risk (see Van Tyne et al.).
Image Credit: Shannon Heuklom
Perspective
Long-Lost Relative Claims Orphan Gene: oskar in a Wasp
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002045
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Review
The Liberation of Embryonic Stem Cells
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002019
Research Articles
Survival Motor Neuron Protein Regulates Stem Cell Division, Proliferation, and Differentiation in Drosophila
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002030
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002033
Chromatin Organization in Sperm May Be the Major Functional Consequence of Base Composition Variation in the Human Genome
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002036
Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002038
Dynamic Regulation of H3K27 Trimethylation during Arabidopsis Differentiation
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002040
Evolution of Vertebrate Transient Receptor Potential Vanilloid 3 Channels: Opposite Temperature Sensitivity between Mammals and Western Clawed Frogs
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1002041
Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1001353
The Exocyst Protein Sec10 Interacts with Polycystin-2 and Knockdown Causes PKD-Phenotypes
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1001361
Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1001362
Transferability of Type 2 Diabetes Implicated Loci in Multi-Ethnic Cohorts from Southeast Asia
PLOS Genetics: published April 7, 2011 | https://doi.org/10.1371/journal.pgen.1001363
Towards Establishment of a Rice Stress Response Interactome
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002020
Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002025
DNA Damage, Somatic Aneuploidy, and Malignant Sarcoma Susceptibility in Muscular Dystrophies
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002042
Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002047
Highly Precise and Developmentally Programmed Genome Assembly in Paramecium Requires Ligase IV–Dependent End Joining
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002049
Loss-of-Function Mutations in PTPN11 Cause Metachondromatosis, but Not Ollier Disease or Maffucci Syndrome
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1002050
Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1001364
An Evolutionary Genomic Approach to Identify Genes Involved in Human Birth Timing
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1001365
Genome Analysis Reveals Interplay between 5′UTR Introns and Nuclear mRNA Export for Secretory and Mitochondrial Genes
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1001366
14-3-3 Proteins Regulate Exonuclease 1–Dependent Processing of Stalled Replication Forks
PLOS Genetics: published April 14, 2011 | https://doi.org/10.1371/journal.pgen.1001367
NK Cell Receptor/H2-Dk–Dependent Host Resistance to Viral Infection Is Quantitatively Modulated by H2q Inhibitory Signals
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001368
Epigenetic Regulation of Cell Type–Specific Expression Patterns in the Human Mammary Epithelium
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001369
Protein Phosphatase 2A Controls Ethylene Biosynthesis by Differentially Regulating the Turnover of ACC Synthase Isoforms
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001370
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Enhanced Statistical Tests for GWAS in Admixed Populations: Assessment using African Americans from CARe and a Breast Cancer Consortium
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001371
Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001372
The History of African Gene Flow into Southern Europeans, Levantines, and Jews
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001373
Genome-Wide Association Analysis of Soluble ICAM-1 Concentration Reveals Novel Associations at the NFKBIK, PNPLA3, RELA, and SH2B3 Loci
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001374
Adaptations to Climate-Mediated Selective Pressures in Humans
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001375
Ribosomal DNA Deletions Modulate Genome-Wide Gene Expression: “rDNA–Sensitive” Genes and Natural Variation
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001376
PDP-1 Links the TGF-β and IIS Pathways to Regulate Longevity, Development, and Metabolism
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001377
GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001378
Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001379
A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001380
Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum
PLOS Genetics: published April 21, 2011 | https://doi.org/10.1371/journal.pgen.1001383
Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1001381
ESR1 Is Co-Expressed with Closely Adjacent Uncharacterised Genes Spanning a Breast Cancer Susceptibility Locus at 6q25.1
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1001382
The Phylogenetic Origin of oskar Coincided with the Origin of Maternally Provisioned Germ Plasm and Pole Cells at the Base of the Holometabola
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002029
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PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002037
Phosphorylation-Dependent Differential Regulation of Plant Growth, Cell Death, and Innate Immunity by the Regulatory Receptor-Like Kinase BAK1
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002046
Fluctuations in spo0A Transcription Control Rare Developmental Transitions in Bacillus subtilis
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002048
Beyond Missing Heritability: Prediction of Complex Traits
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002051
Deficiency of Huntingtin Has Pleiotropic Effects in the Social Amoeba Dictyostelium discoideum
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002052
Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002053
Arabidopsis HDA6 Regulates Locus-Directed Heterochromatin Silencing in Cooperation with MET1
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002055
Reciprocal Sign Epistasis between Frequently Experimentally Evolved Adaptive Mutations Causes a Rugged Fitness Landscape
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002056
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components
PLOS Genetics: published April 28, 2011 | https://doi.org/10.1371/journal.pgen.1002057