More than a century after the foundation of genetics as a scientific field, researchers are still developing a general theory for how genes can control traits. Recent advances in the conceptualization and formalization of this theory have provided new insights into the estimation of genetic effects and the genetics of evolutionary processes. This image illustrates the use of chicken growth rate to analyze the genetics of domestication (see Álvarez-Castro et al., doi:10.1371/journal.pgen.1000062).
Image Credit: Ernesto González Torterolo and Ignacio Castro (Náchok)
Special Report
Zebrafish VEGF Receptors: A Guideline to Nomenclature
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000064
Review
When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000040
Research Articles
How To Perform Meaningful Estimates of Genetic Effects
PLOS Genetics: published May 2, 2008 | https://doi.org/10.1371/journal.pgen.1000062
The λ Red Proteins Promote Efficient Recombination between Diverged Sequences: Implications for Bacteriophage Genome Mosaicism
PLOS Genetics: published May 2, 2008 | https://doi.org/10.1371/journal.pgen.1000065
SU(VAR)3-7 Links Heterochromatin and Dosage Compensation in Drosophila
PLOS Genetics: published May 2, 2008 | https://doi.org/10.1371/journal.pgen.1000066
A Genetic Screen for Dihydropyridine (DHP)-Resistant Worms Reveals New Residues Required for DHP-Blockage of Mammalian Calcium Channels
PLOS Genetics: published May 9, 2008 | https://doi.org/10.1371/journal.pgen.1000067
Related Articles
An Inducible and Reversible Mouse Genetic Rescue System
PLOS Genetics: published May 9, 2008 | https://doi.org/10.1371/journal.pgen.1000069
Gene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators
PLOS Genetics: published May 9, 2008 | https://doi.org/10.1371/journal.pgen.1000070
Related Articles
The Impact of Recombination on Nucleotide Substitutions in the Human Genome
PLOS Genetics: published May 9, 2008 | https://doi.org/10.1371/journal.pgen.1000071
A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)
PLOS Genetics: published May 9, 2008 | https://doi.org/10.1371/journal.pgen.1000072
HOXA13 Is Essential for Placental Vascular Patterning and Labyrinth Endothelial Specification
PLOS Genetics: published May 16, 2008 | https://doi.org/10.1371/journal.pgen.1000073
A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
PLOS Genetics: published May 16, 2008 | https://doi.org/10.1371/journal.pgen.1000074
Demographic History of European Populations of Arabidopsis thaliana
PLOS Genetics: published May 16, 2008 | https://doi.org/10.1371/journal.pgen.1000075
ATM Promotes the Obligate XY Crossover and both Crossover Control and Chromosome Axis Integrity on Autosomes
PLOS Genetics: published May 23, 2008 | https://doi.org/10.1371/journal.pgen.1000076
Inferring Human Colonization History Using a Copying Model
PLOS Genetics: published May 23, 2008 | https://doi.org/10.1371/journal.pgen.1000078
Related Articles
Targeted Deficiency of the Transcriptional Activator Hnf1α Alters Subnuclear Positioning of Its Genomic Targets
PLOS Genetics: published May 23, 2008 | https://doi.org/10.1371/journal.pgen.1000079
BRCA1 and BRCA2 Missense Variants of High and Low Clinical Significance Influence Lymphoblastoid Cell Line Post-Irradiation Gene Expression
PLOS Genetics: published May 23, 2008 | https://doi.org/10.1371/journal.pgen.1000080
Genomic Profiling Identifies GATA6 as a Candidate Oncogene Amplified in Pancreatobiliary Cancer
PLOS Genetics: published May 23, 2008 | https://doi.org/10.1371/journal.pgen.1000081
The Inexorable Spread of a Newly Arisen Neo-Y Chromosome
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000082
Related Articles
Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000083
Specificity of the STAT4 Genetic Association for Severe Disease Manifestations of Systemic Lupus Erythematosus
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000084
Systematic Identification of Genes that Regulate Neuronal Wiring in the Drosophila Visual System
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000085
Complete Genome Sequence of the Complex Carbohydrate-Degrading Marine Bacterium, Saccharophagus degradans Strain 2-40T
PLOS Genetics: published May 30, 2008 | https://doi.org/10.1371/journal.pgen.1000087