At embryonic day 7.5, most XX primordial germ cells show an inactive X chromosome like their somatic neighbour cells. Blimp1:gfp primordial germ cells (green) after 2 days of culture showing a distinct trimetylation of histone 3 on lysine 27 (H3K27me3) nuclear accumulation (pink) indicative of the inactive X chromosome (see Chuva de Sousa Lopes et al., e30).
Image Credit: Confocal micrograph provided by Susana Chuva de Sousa Lopes and Katsuhiko Hayashi
Interview
Ready for Her Close-Up: An Interview with Elaine Strass
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000002
Review
What Can Genome-Wide Association Studies Tell Us about the Genetics of Common Disease?
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.0040033
Research Articles
ER Stress-Mediated Apoptosis in a New Mouse Model of Osteogenesis imperfecta
PLOS Genetics: published February 1, 2008 | https://doi.org/10.1371/journal.pgen.0040007
Network Discovery Pipeline Elucidates Conserved Time-of-Day–Specific cis-Regulatory Modules
PLOS Genetics: published February 1, 2008 | https://doi.org/10.1371/journal.pgen.0040014
Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries
PLOS Genetics: published February 1, 2008 | https://doi.org/10.1371/journal.pgen.0040015
Comparing Patterns of Natural Selection across Species Using Selective Signatures
PLOS Genetics: published February 8, 2008 | https://doi.org/10.1371/journal.pgen.0040023
Related Articles
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040024
The Evolution of Spinnable Cotton Fiber Entailed Prolonged Development and a Novel Metabolism
PLOS Genetics: published February 1, 2008 | https://doi.org/10.1371/journal.pgen.0040025
Genome-Wide Expression of Azoospermia Testes Demonstrates a Specific Profile and Implicates ART3 in Genetic Susceptibility
PLOS Genetics: published February 8, 2008 | https://doi.org/10.1371/journal.pgen.0040026
Dynamic Regulation of ARGONAUTE4 within Multiple Nuclear Bodies in Arabidopsis thaliana
PLOS Genetics: published February 8, 2008 | https://doi.org/10.1371/journal.pgen.0040027
Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040028
Subfunctionalization of Duplicated Zebrafish pax6 Genes by cis-Regulatory Divergence
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040029
X Chromosome Activity in Mouse XX Primordial Germ Cells
PLOS Genetics: published February 8, 2008 | https://doi.org/10.1371/journal.pgen.0040030
Drosophila brca2 Is Required for Mitotic and Meiotic DNA Repair and Efficient Activation of the Meiotic Recombination Checkpoint
PLOS Genetics: published February 8, 2008 | https://doi.org/10.1371/journal.pgen.0040031
Adaptations to Climate in Candidate Genes for Common Metabolic Disorders
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040032
Unintentional miRNA Ablation Is a Risk Factor in Gene Knockout Studies: A Short Report
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040034
Expression Profiles Reveal Parallel Evolution of Epistatic Interactions Involving the CRP Regulon in Escherichia coli
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040035
Motility Screen Identifies Drosophila IGF-II mRNA-Binding Protein—Zipcode-Binding Protein Acting in Oogenesis and Synaptogenesis
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040036
Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
PLOS Genetics: published February 15, 2008 | https://doi.org/10.1371/journal.pgen.0040037
Alternative Splicing Regulation During C. elegans Development: Splicing Factors as Regulated Targets
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000001
The Secreted Metalloprotease ADAMTS20 Is Required for Melanoblast Survival
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000003
Variation in Molybdenum Content Across Broadly Distributed Populations of Arabidopsis thaliana Is Controlled by a Mitochondrial Molybdenum Transporter (MOT1)
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000004
Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000005
Related Articles
Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000006
Genome-Wide Assessments Reveal Extremely High Levels of Polymorphism of Two Active Families of Mouse Endogenous Retroviral Elements
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000007
Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000008
Drosophila Histone Deacetylase-3 Controls Imaginal Disc Size through Suppression of Apoptosis
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000009
Identification of the Yellow Skin Gene Reveals a Hybrid Origin of the Domestic Chicken
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000010
RSF Governs Silent Chromatin Formation via Histone H2Av Replacement
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000011
DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000015
Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000020
The Mediator Subunit MDT-15 Confers Metabolic Adaptation to Ingested Material
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000021
The C. elegans Opa1 Homologue EAT-3 Is Essential for Resistance to Free Radicals
PLOS Genetics: published February 29, 2008 | https://doi.org/10.1371/journal.pgen.1000022