August 2007

The endocardium is the inner lining of the heart, and interactions between the endocardium and heart muscle play essential roles during heart development. Shown here is the heart of a 24-hour-old zebrafish embryo. At this stage, the heart is a simple tube in which contractions have just begun (see Bussmann et al., e140).

Image Credit: Image by Jeroen Bussmann.

Review

“Myc’ed Messages”: Myc Induces Transcription of E2F1 while Inhibiting Its Translation via a microRNA Polycistron

Hilary A Coller, Joshua J Forman, Aster Legesse-Miller

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030146

Research Articles

Substitution as a Mechanism for Genetic Robustness: The Duplicated Deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae

Meleah A Hickman, Laura N Rusche

PLOS Genetics: published August 3, 2007 | https://doi.org/10.1371/journal.pgen.0030126

Dynein Modifiers in C. elegans: Light Chains Suppress Conditional Heavy Chain Mutants

Sean M O'Rourke, Marc D Dorfman, J. Clayton Carter, Bruce Bowerman

PLOS Genetics: published August 3, 2007 | https://doi.org/10.1371/journal.pgen.0030128

Mouse Pachytene Checkpoint 2 (Trip13) Is Required for Completing Meiotic Recombination but Not Synapsis

Xin Li, John C Schimenti

PLOS Genetics: published August 10, 2007 | https://doi.org/10.1371/journal.pgen.0030130

SREBP Controls Oxygen-Dependent Mobilization of Retrotransposons in Fission Yeast

Alfica Sehgal, Chih-Yung S Lee, Peter J Espenshade

PLOS Genetics: published August 10, 2007 | https://doi.org/10.1371/journal.pgen.0030131

The Role of AtMUS81 in Interference-Insensitive Crossovers in A. thaliana

Luke E Berchowitz, Kirk E Francis, Alexandra L Bey, Gregory P Copenhaver

PLOS Genetics: published August 10, 2007 | https://doi.org/10.1371/journal.pgen.0030132

Global Dissemination of a Single Mutation Conferring White Pericarp in Rice

Megan T Sweeney, Michael J Thomson, Yong Gu Cho, Yong Jin Park, Scott H Williamson, Carlos D Bustamante, Susan R McCouch

PLOS Genetics: published August 10, 2007 | https://doi.org/10.1371/journal.pgen.0030133

A Screen for Suppressors of Gross Chromosomal Rearrangements Identifies a Conserved Role for PLP in Preventing DNA Lesions

Pamela Kanellis, Mark Gagliardi, Judit P Banath, Rachel K Szilard, Shinichiro Nakada, Sarah Galicia, Frederic D Sweeney, Diane C Cabelof, Peggy L Olive, Daniel Durocher

PLOS Genetics: published August 10, 2007 | https://doi.org/10.1371/journal.pgen.0030134

Unbiased Gene Expression Analysis Implicates the huntingtin Polyglutamine Tract in Extra-mitochondrial Energy Metabolism

Jong-Min Lee, Elena V Ivanova, Ihn Sik Seong, Tanya Cashorali, Isaac Kohane, James F Gusella, Marcy E MacDonald

PLOS Genetics: published August 17, 2007 | https://doi.org/10.1371/journal.pgen.0030135

Identification and Characterization of Cell Type–Specific and Ubiquitous Chromatin Regulatory Structures in the Human Genome

Hualin Xi, Hennady P Shulha, Jane M Lin, Teresa R Vales, Yutao Fu, David M Bodine, Ronald D. G McKay, Josh G Chenoweth, Paul J Tesar, Terrence S Furey, Bing Ren, Zhiping Weng, Gregory E Crawford

PLOS Genetics: published August 17, 2007 | https://doi.org/10.1371/journal.pgen.0030136

Maintenance of Paternal Methylation and Repression of the Imprinted H19 Gene Requires MBD3

Kimberly J Reese, Shu Lin, Raluca I Verona, Richard M Schultz, Marisa S Bartolomei

PLOS Genetics: published August 17, 2007 | https://doi.org/10.1371/journal.pgen.0030137

Genome Analysis of Minibacterium massiliensis Highlights the Convergent Evolution of Water-Living Bacteria

Stéphane Audic, Catherine Robert, Bernard Campagna, Hugues Parinello, Jean-Michel Claverie, Didier Raoult, Michel Drancourt

PLOS Genetics: published August 24, 2007 | https://doi.org/10.1371/journal.pgen.0030138

Mutation in Mouse Hei10, an E3 Ubiquitin Ligase, Disrupts Meiotic Crossing Over

Jeremy O Ward, Laura G Reinholdt, William W Motley, Lisa M Niswander, Dekker C Deacon, Laurie B Griffin, Kristofor K Langlais, Vickie L Backus, Kerry J Schimenti, Marilyn J O'Brien, John J Eppig, John C Schimenti

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030139

Early Endocardial Morphogenesis Requires Scl/Tal1

Jeroen Bussmann, Jeroen Bakkers, Stefan Schulte-Merker

PLOS Genetics: published August 24, 2007 | https://doi.org/10.1371/journal.pgen.0030140

A Discrete Class of Intergenic DNA Dictates Meiotic DNA Break Hotspots in Fission Yeast

Gareth A Cromie, Randy W Hyppa, Hugh P Cam, Joseph A Farah, Shiv I. S Grewal, Gerald R Smith

PLOS Genetics: published August 24, 2007 | https://doi.org/10.1371/journal.pgen.0030141

The Complete Genome Sequence of Yersinia pseudotuberculosis IP31758, the Causative Agent of Far East Scarlet-Like Fever

Mark Eppinger, M. J Rosovitz, Wolfgang Florian Fricke, David A Rasko, Galina Kokorina, Corinne Fayolle, Luther E Lindler, Elisabeth Carniel, Jacques Ravel

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030142

Assessing the Significance of Conserved Genomic Aberrations Using High Resolution Genomic Microarrays

Mitchell Guttman, Carolyn Mies, Katarzyna Dudycz-Sulicz, Sharon J Diskin, Don A Baldwin, Christian J Stoeckert Jr., Gregory R Grant

PLOS Genetics: published August 24, 2007 | https://doi.org/10.1371/journal.pgen.0030143

Linkage Disequilibrium in Wild Mice

Cathy C Laurie, Deborah A Nickerson, Amy D Anderson, Bruce S Weir, Robert J Livingston, Matthew D Dean, Kimberly L Smith, Eric E Schadt, Michael W Nachman

PLOS Genetics: published August 24, 2007 | https://doi.org/10.1371/journal.pgen.0030144

Systematic Identification of cis-Regulatory Sequences Active in Mouse and Human Embryonic Stem Cells

Marica Grskovic, Christina Chaivorapol, Alexandre Gaspar-Maia, Hao Li, Miguel Ramalho-Santos

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030145

Gene Duplication and Adaptive Evolution of Digestive Proteases in Drosophila arizonae Female Reproductive Tracts

Erin S Kelleher, Willie J Swanson, Therese A Markow

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030148

Correction

Correction: COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity

Isao Kurihara, Dong-Kee Lee, Fabrice G Petit, Jaewook Jeong, Kevin Lee, John P Lydon, Francesco J DeMayo, Ming-Jer Tsai, Sophia Y Tsai

PLOS Genetics: published August 31, 2007 | https://doi.org/10.1371/journal.pgen.0030149

Cover

The heart of a 24-hour-old zebrafish embryo