March 2007

The images illustrate the phenotypic spectrum, uncovered in one zebrafish strain, following partial inhibition of Hsp90. The frequency and range of severity observed after inbreeding suggests involvement of multiple genes and thresholds. The microphthalmia and anophthalmia are reminiscent of similar human malformations, often unilateral and without clear inheritance patterns (see see Yeyati et al., e43).

Image Credit: Photographs by Patricia L. Yeyati.

Interview

Off the Beaten Path: An Interview with Spencer Wells

Jane Gitschier

PLOS Genetics: published March 30, 2007 | https://doi.org/10.1371/journal.pgen.0030044

Research Articles

A Caenorhabditis elegans Wild Type Defies the Temperature–Size Rule Owing to a Single Nucleotide Polymorphism in tra-3

Jan E Kammenga, Agnieszka Doroszuk, Joost A. G Riksen, Esther Hazendonk, Laurentiu Spiridon, Andrei-Jose Petrescu, Marcel Tijsterman, Ronald H. A Plasterk, Jaap Bakker

PLOS Genetics: published March 2, 2007 | https://doi.org/10.1371/journal.pgen.0030034

High-Resolution Mapping Reveals Links of HP1 with Active and Inactive Chromatin Components

Elzo de Wit, Frauke Greil, Bas van Steensel

PLOS Genetics: published March 2, 2007 | https://doi.org/10.1371/journal.pgen.0030038

Function-Altering SNPs in the Human Multidrug Transporter Gene ABCB1 Identified Using a Saccharomyces-Based Assay

Hotcherl Jeong, Ira Herskowitz, Deanna L Kroetz, Jasper Rine

PLOS Genetics: published March 9, 2007 | https://doi.org/10.1371/journal.pgen.0030039

Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

Peter F Zipfel, Matthew Edey, Stefan Heinen, Mihály Józsi, Heiko Richter, Joachim Misselwitz, Bernd Hoppe, Danny Routledge, Lisa Strain, Anne E Hughes, Judith A Goodship, Christoph Licht, Timothy H. J Goodship, Christine Skerka

PLOS Genetics: published March 16, 2007 | https://doi.org/10.1371/journal.pgen.0030041

Association between Common Variation in 120 Candidate Genes and Breast Cancer Risk

Paul D. P Pharoah, Jonathan Tyrer, Alison M Dunning, Douglas F Easton, Bruce A. J Ponder, SEARCH Investigators

PLOS Genetics: published March 16, 2007 | https://doi.org/10.1371/journal.pgen.0030042

Hsp90 Selectively Modulates Phenotype in Vertebrate Development

Patricia L Yeyati, Ruth M Bancewicz, John Maule, Veronica van Heyningen

PLOS Genetics: published March 30, 2007 | https://doi.org/10.1371/journal.pgen.0030043

The Molecular Basis of High-Altitude Adaptation in Deer Mice

Jay F Storz, Stephen J Sabatino, Federico G Hoffmann, Eben J Gering, Hideaki Moriyama, Nuno Ferrand, Bruno Monteiro, Michael W Nachman

PLOS Genetics: published March 30, 2007 | https://doi.org/10.1371/journal.pgen.0030045

Incorporating Single-Locus Tests into Haplotype Cladistic Analysis in Case-Control Studies

Jianfeng Liu, Chris Papasian, Hong-Wen Deng

PLOS Genetics: published March 23, 2007 | https://doi.org/10.1371/journal.pgen.0030046

Forward-Time Simulations of Human Populations with Complex Diseases

Bo Peng, Christopher I Amos, Marek Kimmel

PLOS Genetics: published March 23, 2007 | https://doi.org/10.1371/journal.pgen.0030047

Genome-Wide Linkage Analysis of Malaria Infection Intensity and Mild Disease

Christian Timmann, Jennifer A Evans, Inke R König, André Kleensang, Franz Rüschendorf, Julia Lenzen, Jürgen Sievertsen, Christian Becker, Yeetey Enuameh, Kingsley Osei Kwakye, Ernest Opoku, Edmund N. L Browne, Andreas Ziegler, Peter Nürnberg, Rolf D Horstmann

PLOS Genetics: published March 23, 2007 | https://doi.org/10.1371/journal.pgen.0030048

Cover

Partial inhibition of Hsp90