September 2005

Mouse Chromosome 14 with markers arrayed along the diagonal from centromere (lower left) to telomere (upper right). Typical domains oflinkage disequilibrium arising from selection of coadapted sets of allelesat genomically clustered, functionally related genes show as regions of warmcolor surrounded by white boxes. Similar domains occur on all chromosomes see Petkov et al.).

Image Credit: Image created by Dr. Joel Graber with a custom Perl script, using the GD graphics package.

Interview

Turning the Tables—An Interview with Nicholas Wade

Jane Gitschier

PLOS Genetics: published September 30, 2005 | https://doi.org/10.1371/journal.pgen.0010045

Research Articles

Differential Expression of Novel Potential Regulators in Hematopoietic Stem Cells

E. Camilla Forsberg, Susan S Prohaska, Sol Katzman, Garrett C Heffner, Josh M Stuart, Irving L Weissman

PLOS Genetics: published September 2, 2005 | https://doi.org/10.1371/journal.pgen.0010028

Uncoupling of Longevity and Telomere Length in C. elegans

Marcela Raices, Hugo Maruyama, Andrew Dillin, Jan Karlseder

PLOS Genetics: published September 2, 2005 | https://doi.org/10.1371/journal.pgen.0010030

Confounding from Cryptic Relatedness in Case-Control Association Studies

Benjamin F Voight, Jonathan K Pritchard

PLOS Genetics: published September 2, 2005 | https://doi.org/10.1371/journal.pgen.0010032

Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes

Petko M Petkov, Joel H Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L King, Kenneth Paigen

PLOS Genetics: published September 9, 2005 | https://doi.org/10.1371/journal.pgen.0010033

Protein Modularity of Alternatively Spliced Exons Is Associated with Tissue-Specific Regulation of Alternative Splicing

Yi Xing, Christopher J Lee

PLOS Genetics: published September 16, 2005 | https://doi.org/10.1371/journal.pgen.0010034

Pervasive Adaptive Evolution in Primate Seminal Proteins

Nathaniel L Clark, Willie J Swanson

PLOS Genetics: published September 16, 2005 | https://doi.org/10.1371/journal.pgen.0010035

Yeast Model Uncovers Dual Roles of Mitochondria in the Action of Artemisinin

Wei Li, Weike Mo, Dan Shen, Libo Sun, Juan Wang, Shan Lu, Jane M Gitschier, Bing Zhou

PLOS Genetics: published September 16, 2005 | https://doi.org/10.1371/journal.pgen.0010036

Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

Xiaohua Shen, Ronald E Ellis, Kenjiro Sakaki, Randal J Kaufman

PLOS Genetics: published September 23, 2005 | https://doi.org/10.1371/journal.pgen.0010037

Acinar Cell Apoptosis in Serpini2-Deficient Mice Models Pancreatic Insufficiency

Stacie K Loftus, Jennifer L Cannons, Arturo Incao, Evgenia Pak, Amy Chen, Patricia M Zerfas, Mark A Bryant, Leslie G Biesecker, Pamela L Schwartzberg, William J Pavan

PLOS Genetics: published September 23, 2005 | https://doi.org/10.1371/journal.pgen.0010038

Comparative Gene Expression Analysis by a Differential Clustering Approach: Application to the Candida albicans Transcription Program

Jan Ihmels, Sven Bergmann, Judith Berman, Naama Barkai

PLOS Genetics: published September 30, 2005 | https://doi.org/10.1371/journal.pgen.0010039

Cover

Mouse Chromosome 14