This Perspective [1] discusses research findings presented in a PLOS Genetics Research Article [2] that has since been retracted [3]. Statements in [1] supported only by the retracted article [2, 3] should be disregarded.
The PLOS Genetics Editors consider that [1] continues to provide a useful perspective on the role of miR-22 in hematopoiesis after the findings in [2] are dismissed.
References
- 1. Wurm AA, Tenen DG, Behre G. The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene? PLoS Genet. 2017;13(1): e1006505.
- 2. Shen C, Chen M-T, Zhang X-H, Yin X-L, Ning H-M, Su R, et al. RETRACTED: The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. PLoS Genet. 2016;12(9):e1006259. pmid:27617961
- 3. The PLOS Genetics Editors. Retraction: The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia. PLoS Genet. 2026;22(7):e1012224. pmid:42424268
Citation: The PLOS Genetics Editors (2026) Correction: The Janus-faced Nature of miR-22 in Hematopoiesis: Is It an Oncogenic Tumor Suppressor or Rather a Tumor-Suppressive Oncogene? PLoS Genet 22(8): e1012281. https://doi.org/10.1371/journal.pgen.1012281
Published: August 25, 2026
Copyright: © 2026 The PLOS Genetics Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.