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Open Access

Retraction

Retraction: miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2

  • The PLOS Genetics Editors

Following the publication of this article [1], concerns were raised regarding results presented in Figs 3, 4, 6, 7, S2, S3, S4, and S5. Specifically,

  • At least 16 transwell migration/invasion assay panels presented in Figs 3, 4, 6 S2, S3, S4, and S5 of [1] appear similar to other transwell migration/invasion assay panels presented in [1–9], where they have been used to represent results obtained under different experimental conditions, or results obtained from different cell lines.
  • The Fig 7E right Lenti-inhibitor panel of [1] appears similar to the Fig 7E right Lenti-inhibitor panel of [2, retracted in 3], despite the studies describing experiments using different cell lines.
  • The left and right regions of the Fig 7F Lenti-inhibitor x12.5 panel appear more similar than would be expected from independent results.
  • The Fig 7K CCNE2 Agomir panel of [1] appears similar to the Fig 6E TFGBR1 NC panel of [10].
  • The Fig S3C H292-mimic panel of [1] appears similar to the Fig 2E H1299-mimic panel of [4].

This article [1] is also linked to a larger group of articles connected by concerns about image reuse.

In light of the above concerns that question the validity and reliability of the reported data, the PLOS Genetics Editors retract this article.

PG, HW, ZY, ML, YN, and GS did not agree with the retraction. JY, JZ, XW, WW, HL, and YW either did not respond directly or could not be reached.

References

  1. 1. Gao P, Wang H, Yu J, Zhang J, Yang Z, Liu M, et al. (2018) miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2. PLoS Genet 14(12): e1007790. pmid:30557355
  2. 2. Gao P, Wang D, Liu M, Chen S, Yang Z, Zhang J, et al. (2020) DNA methylation-mediated repression of exosomal miR-652-5p expression promotes oesophageal squamous cell carcinoma aggressiveness by targeting PARG and VEGF pathways. PLoS Genet 16(4): e1008592. pmid:32343702
  3. 3. The PLOS Genetics Editors (2024) Retraction: DNA methylation-mediated repression of exosomal miR-652-5p expression promotes oesophageal squamous cell carcinoma aggressiveness by targeting PARG and VEGF pathways. PLoS Genet 20(5): e1011269.
  4. 4. Liu M, Zhang Y, Zhang J, Cai H, Zhang C, Yang Z, et al. (2018) MicroRNA-1253 suppresses cell proliferation and invasion of non-small-cell lung carcinoma by targeting WNT5A. Cell Death & Disease 9, 189. pmid:29415994
  5. 5. Gun G, Ding X, Bi N, Wu L, Wang J, Zhang WJ, et al. miR-423-5p in brain metastasis: potential role in diagnostics and molecular biology. Cell Death & Disease 9, 936. pmid:30224667
  6. 6. Jia M, Li Z, Pan M, Tao M, Wang J, and Lu X (2020). LINC-PINT Suppresses the Aggressiveness of Thyroid Cancer by Downregulating miR-767-5p to Induce TET2 Expression. Molecular Therapy Nucleic Acids 22, 319–328. pmid:33230437
  7. 7. Wang K, Yu J, Wang B, Wang H, Shi Z, and Li G. (2019). miR-29a Regulates the Proliferation and Migration of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans of the Lower Extremities. Kidney and Blood Pressure Research, 44(5): 1219–1232. pmid:31614351
  8. 8. Sun G, Ding X, Bi N, Wang Z, Wu L, Zhou W, et al. (2019) Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma. PLoS Genet 15(2): e1007888. pmid:30707694
  9. 9. The PLOS Genetics Editors (2022) Retraction: Molecular predictors of brain metastasis-related microRNAs in lung adenocarcinoma. PLoS Genet 18(12): e1010552. pmid:36525402
  10. 10. Yang Z, He J, Gao P, Niu Y, Zhang J, Wang L, et al. (2017). miR-769-5p suppressed cell proliferation, migration and invasion by targeting TGFBR1 in non-small cell lung carcinoma. Oncotarget 8: 113558–113570. pmid:29371929

Citation: The PLOS Genetics Editors (2024) Retraction: miR-3607-3p suppresses non-small cell lung cancer (NSCLC) by targeting TGFBR1 and CCNE2. PLoS Genet 20(5): e1011270. https://doi.org/10.1371/journal.pgen.1011270

Published: May 7, 2024

Copyright: © 2024 The PLOS Genetics Editors. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.