Figures
The protein CTCF is incorrectly labelled in Fig 1A as CTFC. Please view the correct Fig 1 here, which is also modified to include in Fig 1A CTCF-Cohesins that tether together topologically associated domains between chromosomes.
(A) DNA segment interactions stabilized by CTCF (transcriptional repressor) and cohesins define looped domains that aggregate into clusters of similar transcription outputs (active or silenced), termed topologically associated domains (TADs). TAD aggregation of both cis (with a single chromosome) and trans (involving two or more chromosomes) domains is critical for proper development and normal cell proliferation [1–3]. (B) DNA segment interactions stabilized by cohesins (independent of CTCF) during S phase are critical for meiotic and mitotic sister chromatid tethering, chromosome condensation, and DNA repair [4–6].
Reference
Citation: Skibbens RV (2016) Correction: Of Rings and Rods: Regulating Cohesin Entrapment of DNA to Generate Intra- and Intermolecular Tethers. PLoS Genet 12(12): e1006478. https://doi.org/10.1371/journal.pgen.1006478
Published: December 1, 2016
Copyright: © 2016 Robert V. Skibbens. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.