Figures
Unintended HDR Template Integration Rivals Desired Genome Edits in Drosophila
Composite image of a Drosophila melanogaster head illustrating the outcome of genome editing followed by HDR repair. Red fluorescent eyed Drosophila carry the desired genome edit; green fluorescent eyed Drosophila harbor undesired template vector genome insertional events. The desired and undesired outcomes occur at almost equal frequency, underscoring the need for systematic screening against template vector integration following genome editing. Källstig et al. 2026
Image Credit: Evelyne Ruchti and Brian McCabe
Citation: (2026) PLoS Genetics Issue Image | Vol. 22(7) August 2026. PLoS Genet 22(7): ev22.i07. https://doi.org/10.1371/image.pgen.v22.i07
Published: August 26, 2026
Copyright: © 2026 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Composite image of a Drosophila melanogaster head illustrating the outcome of genome editing followed by HDR repair. Red fluorescent eyed Drosophila carry the desired genome edit; green fluorescent eyed Drosophila harbor undesired template vector genome insertional events. The desired and undesired outcomes occur at almost equal frequency, underscoring the need for systematic screening against template vector integration following genome editing. Källstig et al. 2026
Image Credit: Evelyne Ruchti and Brian McCabe