Figures
MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans
Confocal micrograph of a late larval C. elegans hermaphrodite worm showing mispositioned germline stem cell niche cells, (the distal tip cells, or DTCs) after compound loss-of-function in the Netrin pathway (mig-21(u787) with DTC-specific unc-5/Netrin receptor RNAi). Differential interference contrast image merged with fluorescence z-projection through the two DTCs (membrane fluorescence colored by intensity). These results demonstrate cell-autonomous genetic interaction between mig-21 and the Netrin receptor in directing migration of the DTCs, a role for mig-21 that was previously masked by redundancy. Li et al. 2025
Image Credit: Xin Li and Kacy Gordon
Citation: (2025) PLoS Genetics Issue Image | Vol. 21(9) October 2025. PLoS Genet 21(9): ev21.i09. https://doi.org/10.1371/image.pgen.v21.i09
Published: October 8, 2025
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Confocal micrograph of a late larval C. elegans hermaphrodite worm showing mispositioned germline stem cell niche cells, (the distal tip cells, or DTCs) after compound loss-of-function in the Netrin pathway (mig-21(u787) with DTC-specific unc-5/Netrin receptor RNAi). Differential interference contrast image merged with fluorescence z-projection through the two DTCs (membrane fluorescence colored by intensity). These results demonstrate cell-autonomous genetic interaction between mig-21 and the Netrin receptor in directing migration of the DTCs, a role for mig-21 that was previously masked by redundancy. Li et al. 2025
Image Credit: Xin Li and Kacy Gordon