Figures
Rab23 deletion perturbs ciliogenesis in a context-dependent manner
A confocal microscopy image of Rab23-KO primary cortical neurons at 18 days in-vitro, co-immunostained for the neuronal marker MAP2 (magenta) and the primary cilia marker AC3 (green). Rab23-KO neurons exhibit persistently reduced ciliation and shorter cilia. These findings demonstrate that Rab23 is critical for proper neuronal primary cilia formation and elongation, highlighting its essential role in cilia dynamics during neuronal development. Leong et al. 2025
Image Credit: Wai Lam Tung
Citation: (2025) PLoS Genetics Issue Image | Vol. 21(8) September 2025. PLoS Genet 21(8): ev21.i08. https://doi.org/10.1371/image.pgen.v21.i08
Published: September 8, 2025
Copyright: © 2025 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A confocal microscopy image of Rab23-KO primary cortical neurons at 18 days in-vitro, co-immunostained for the neuronal marker MAP2 (magenta) and the primary cilia marker AC3 (green). Rab23-KO neurons exhibit persistently reduced ciliation and shorter cilia. These findings demonstrate that Rab23 is critical for proper neuronal primary cilia formation and elongation, highlighting its essential role in cilia dynamics during neuronal development. Leong et al. 2025
Image Credit: Wai Lam Tung