Figures
Sparse Local Identity-by-Descent Matrices for Association Mapping
Identity-by-descent (IBD) segments shared from a common ancestor can be used in association mapping to identify genomic regions associated with complex traits. At each specific genetic location, IBD segments shared between individual pairs out of hundreds of thousands of individuals cohorts form a sparse local IBD matrix, which can be used to test the association with complex traits. Here several sparse local IBD matrices at different genetic locations are shown. A fast IBD mapping test can be applied to these matrices on the genome-wide scale. See Chen et al. Download December’s cover page.
Image Credit: Han Chen
Citation: (2024) PLoS Genetics Issue Image | Vol. 19(12) February 2024. PLoS Genet 19(12): ev19.i12. https://doi.org/10.1371/image.pgen.v19.i12
Published: February 27, 2024
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Identity-by-descent (IBD) segments shared from a common ancestor can be used in association mapping to identify genomic regions associated with complex traits. At each specific genetic location, IBD segments shared between individual pairs out of hundreds of thousands of individuals cohorts form a sparse local IBD matrix, which can be used to test the association with complex traits. Here several sparse local IBD matrices at different genetic locations are shown. A fast IBD mapping test can be applied to these matrices on the genome-wide scale. See Chen et al. Download December’s cover page.
Image Credit: Han Chen