Figures
Distinct modes of morphogenetic regulation by primary cilia
Studying complexities in utilization of GLI-effectors point to the tissue-specific regulation of hedgehog pathway repression by primary cilia. Here skeletal stained embryos that are wild-type (top left), conditional knockout for Gpr161 (bottom left), and conditional knockout for Gpr161 and lacking Gli2 (top right) or expressing Gli3 repressor (bottom right) are shown. These embryos depict the distinct modes by which the cilia generated GLI effectors regulate morpho-phenotypic outcomes from lack of hedgehog pathway repression. See Hwang et al. Download November’s cover page.
Image Credit: Sun-hee Hwang and Saikat Mukhopadhyay
Citation: (2023) PLoS Genetics Issue Image | Vol. 19(11) December 2023. PLoS Genet 19(11): ev19.i11. https://doi.org/10.1371/image.pgen.v19.i11
Published: December 1, 2023
Copyright: © 2023 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Studying complexities in utilization of GLI-effectors point to the tissue-specific regulation of hedgehog pathway repression by primary cilia. Here skeletal stained embryos that are wild-type (top left), conditional knockout for Gpr161 (bottom left), and conditional knockout for Gpr161 and lacking Gli2 (top right) or expressing Gli3 repressor (bottom right) are shown. These embryos depict the distinct modes by which the cilia generated GLI effectors regulate morpho-phenotypic outcomes from lack of hedgehog pathway repression. See Hwang et al. Download November’s cover page.
Image Credit: Sun-hee Hwang and Saikat Mukhopadhyay