Figures
c-Myc ameliorates the hepatobiliary disease and growth defect caused by hepatic Rps6 deficiency.
A modest increase in the level of hepatic c-Myc provided by an Albumin-c-Myc transgene rescues the neonatal growth defect and significantly improves hepatobiliary disease in mice with hepatic ribosomal protein S6 (Rps6) insufficiency (△S6 mice). While the △S6 mouse (second from left) is runted and has a yellow-tinged coat due to a failure of bile duct development and cholestatic-induced hepatocyte death, the mouse expressing a higher level of c-Myc (△S6:c-Myc mouse) (far right) is indistinguishable from the wild-type (WT) mouse (far-left) or its Albumin-c-Myc littermate (third from left) in terms of size and lacks the jaundiced (yellowed) coat of the △S6 mouse. See Comerford et al. Download January's cover page.
Image Credit: R.E. Hammer and S.A. Comerford
Citation: (2023) PLoS Genetics Issue Image | Vol. 19(1) February 2023. PLoS Genet 19(1): ev19.i01. https://doi.org/10.1371/image.pgen.v19.i01
Published: February 15, 2023
Copyright: © 2023 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A modest increase in the level of hepatic c-Myc provided by an Albumin-c-Myc transgene rescues the neonatal growth defect and significantly improves hepatobiliary disease in mice with hepatic ribosomal protein S6 (Rps6) insufficiency (△S6 mice). While the △S6 mouse (second from left) is runted and has a yellow-tinged coat due to a failure of bile duct development and cholestatic-induced hepatocyte death, the mouse expressing a higher level of c-Myc (△S6:c-Myc mouse) (far right) is indistinguishable from the wild-type (WT) mouse (far-left) or its Albumin-c-Myc littermate (third from left) in terms of size and lacks the jaundiced (yellowed) coat of the △S6 mouse. See Comerford et al. Download January's cover page.
Image Credit: R.E. Hammer and S.A. Comerford