Figures
TIAM-1 differentially regulates dendritic and axonal microtubule organization in patterning neuronal development through its multiple domains.
PVD neuron of tiam-1 mutants show dramatic loss of dendritic branches and over-extension of the axon (the first panel). Expressing different TIAM-1 fragment, including TIAM-1A (the second panel), TIAM-1B (the third panel), TIAM-1C (the forth panel), and TIAM-1N539 (the bottom panel) in tiam-1 null mutants restore different subcompartments of PVD neuron. These results suggest that axonal growth and dendritic development are respectively controlled by different regions of TIAM-1. See Lin et al.
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Image Credit: Chin-Hsien Lin
Citation: (2022) PLoS Genetics Issue Image | Vol. 18(10) November 2022. PLoS Genet 18(10): ev18.i10. https://doi.org/10.1371/image.pgen.v18.i10
Published: November 1, 2022
Copyright: © 2022 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PVD neuron of tiam-1 mutants show dramatic loss of dendritic branches and over-extension of the axon (the first panel). Expressing different TIAM-1 fragment, including TIAM-1A (the second panel), TIAM-1B (the third panel), TIAM-1C (the forth panel), and TIAM-1N539 (the bottom panel) in tiam-1 null mutants restore different subcompartments of PVD neuron. These results suggest that axonal growth and dendritic development are respectively controlled by different regions of TIAM-1. See Lin et al.
Download October's cover page.
Image Credit: Chin-Hsien Lin