Figures
Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice.
Confocal image of a P5 mouse ovary section staining with laminin (red), proliferating cell nuclear antigen (green), and DAPI (blue). The medulla, the cortical region, and different types of growing follicles can be observed. As shown by Torres-Cano et al., WT1 is necessary for the activation of both male and female sex-determining pathways. Its deletion during early gonadogenesis produces dramatic defects in adult sex development. See Torres-Cano et al.
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Image Credit: Torres-Cano et al., pgen.1010240
Citation: (2022) PLoS Genetics Issue Image | Vol. 18(6) June 2022. PLoS Genet 18(6): ev18.i06. https://doi.org/10.1371/image.pgen.v18.i06
Published: June 30, 2022
Copyright: © 2022 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Confocal image of a P5 mouse ovary section staining with laminin (red), proliferating cell nuclear antigen (green), and DAPI (blue). The medulla, the cortical region, and different types of growing follicles can be observed. As shown by Torres-Cano et al., WT1 is necessary for the activation of both male and female sex-determining pathways. Its deletion during early gonadogenesis produces dramatic defects in adult sex development. See Torres-Cano et al.
Download June’s cover page.
Image Credit: Torres-Cano et al., pgen.1010240