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PLoS Genetics Issue Image | Vol. 18(4) April 2022

The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation

Dorsal view of a Drosophila larval brain stained for mitotic chromatin (magenta) and the neuronal marker Prospero (orange). Asymmetrically dividing stem cells expressing the Deadpan protein (cyan) are located within Prospero-positive regions in the central part of the brain and in the ventral ganglion. See Gallaud et al.

Download April’s cover page.

Image Credit: Emmanuel Gallaud (image analysis) and Régis Giet (data acquisition).

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The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation

Dorsal view of a Drosophila larval brain stained for mitotic chromatin (magenta) and the neuronal marker Prospero (orange). Asymmetrically dividing stem cells expressing the Deadpan protein (cyan) are located within Prospero-positive regions in the central part of the brain and in the ventral ganglion. See Gallaud et al.

Download April’s cover page.

Image Credit: Emmanuel Gallaud (image analysis) and Régis Giet (data acquisition).

https://doi.org/10.1371/image.pgen.v18.i04.g001