Figures
Mistranslation puts cells on high alert
The easily angered sage Durvasa from Indian mythology is adapted here to represent mistranslating cells (right). Sages on the left depict relatively "calm" wild type cells. Durvasa gets into trouble from indiscriminate cursing; likewise, mistranslating cells incur a cost. However, just as Durvasa has a short fuse, they accumulate more Lon protease (more fireballs in the chest) and are better prepared for danger than wild type cells. On encountering DNA damaging agents (the demon), mistranslating cells quickly activate the SOS response (thunderbolts from Durvasa), ensuring survival; whereas normal cells (calm sages) respond slowly and are more likely to die. See Samhita et al.
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Image Credit: Pranjal Gupta
Citation: (2020) PLoS Genetics Issue Image | Vol. 16(3) April 2020. PLoS Genet 16(3): ev16.i03. https://doi.org/10.1371/image.pgen.v16.i03
Published: April 6, 2020
Copyright: © 2020 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The easily angered sage Durvasa from Indian mythology is adapted here to represent mistranslating cells (right). Sages on the left depict relatively "calm" wild type cells. Durvasa gets into trouble from indiscriminate cursing; likewise, mistranslating cells incur a cost. However, just as Durvasa has a short fuse, they accumulate more Lon protease (more fireballs in the chest) and are better prepared for danger than wild type cells. On encountering DNA damaging agents (the demon), mistranslating cells quickly activate the SOS response (thunderbolts from Durvasa), ensuring survival; whereas normal cells (calm sages) respond slowly and are more likely to die. See Samhita et al.
Download March's cover page.
Image Credit: Pranjal Gupta