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PLoS Genetics Issue Image | Vol. 15(8) August 2019

Gǔn and Yǔ tame the flood.

This legend of Ancient China is used to depict how eukaryotic cells control cellular dNTP pool. The blue river with sprays (A, G, C, T) represents the dNTP pool. The rock denotes Crt1, which represses excessive dNTP streams under normal condition. When a rush of water comes from the spring thaw, the Father of Yǔ禹 (Gǔn鲧), representing Dun1, removes some rocks and meanwhile adds a waterlock (Hug1) to achieve moderate streams. If it turns into a great flood, Emperor Yǔ removes the rest of rocks and waterlocks to allow the torrent to go through. See Li et al.

Download August's cover page.

Image Credit: Ms. Yuyao Du

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Gǔn and Yǔ tame the flood.

This legend of Ancient China is used to depict how eukaryotic cells control cellular dNTP pool. The blue river with sprays (A, G, C, T) represents the dNTP pool. The rock denotes Crt1, which represses excessive dNTP streams under normal condition. When a rush of water comes from the spring thaw, the Father of Yǔ禹 (Gǔn鲧), representing Dun1, removes some rocks and meanwhile adds a waterlock (Hug1) to achieve moderate streams. If it turns into a great flood, Emperor Yǔ removes the rest of rocks and waterlocks to allow the torrent to go through. See Li et al.

Download August's cover page.

Image Credit: Ms. Yuyao Du

https://doi.org/10.1371/image.pgen.v15.i08.g001